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Contact details:
| Tel: | +44 20 7882 2567 |
| Fax: | +44 20 7882 7171 |
| Email: | d.bergamaschi@qmul.ac.uk |
| Address: |
Centre for Cutaneous Research, |
Biography
After my Bsc in Biological Science at the University of Milan in 1994, I studied Cancer Pharmacology at a postgraduate level at the Mario Negri Institute of Pharmacological Research until 1998. I then moved to London where I obtained a postdoctoral position at the Ludwig Institute of Cancer Research at the UCL (1999-2005). In November 2005 I was appointed as a Lecturer at the Centre for Cutaneous Research, Blizard Institute of Cell and Molecular Science.
Research Activity
My major interest is the intrinsic resistance of melanocytes to apoptosis (which is the main pathway through which cancer cells could die) during malignant progression. Therefore my research goal will be to understand the physiological roles of the key players involved in apoptosis in melanocytes, with a special regards to the p53 family members signalling pathways some how altered in melanomas.
Key Publications
. Philpott MP, Bergamaschi D and Storey A. Models for skin cancer. In: Alison MR (Ed.) The Cancer Handbook , 2nd Edition, Wiley & Sons, Chichester , England , UK , pp. 1164-1175 [Chp86] (2007).
. Bergamaschi D , Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N, Smith P, Gasco M, Crook T, Lu X. iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet. 2006 Oct; 38(10):1133-1141.
. Bergamaschi D , Samuels Y, Zhong S, Lu X. Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation. Oncogene 2005 May; 24(23):3836-41.
. Bergamaschi D , Samuels Y, Jin B, Duraisingham S, Crook T, Lu X. ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol. 2004 Feb; 24(3):1341-50.
. Bergamaschi D , Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, Yulug I, Merlano M, Numico G, Comino A, Attard M, Reelfs O, Gusterson B, Bell AK, Heath V, Tavassoli M, Farrell PJ, Smith P, Lu X, Crook T. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell. 2003 Apr; 3(4):387-402.
. Bergamaschi D , Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE , Lu X. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet. 2003 Feb; 33(2):162-7.
. Samuels-Lev Y*, O'Connor DJ*, Bergamaschi D* , Trigiante G, Hsieh JK, Zhong S, Campargue I, Naumovski L, Crook T, Lu X. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell. 2001 Oct; 8(4):781-94. ( *equal contribution).
