Home| Professor of Diabetes and Autoimmunity |
| Research Lead, Centre for Diabetes |
Contact details:
| Tel: | +44 20 7882 2482 |
| Fax: | +44 20 7882 2186 |
| Email: | r.d.g.leslie@qmul.ac.uk |
| Address: |
Centre for Diabetes, |
Biography
Professor David Leslie is consultant physician at St Bartholomew's Hospital and Professor of Diabetes and Autoimmunity at the Blizard Institute of Cell and Molecular Science in the University of London .
He qualified and trained at Imperial College and subsequently at King's College Hospital and Royal Victoria Infirmary, Newcastle . He was an MRC Travelling Fellow at the University of Chicago, USA, and Welcome Trust Senior Clincal Research Fellow at both King's College and Charing Cross and Westminster Medical Schools .
He has an interest in the cause of autoimmune diabetes through the study of twins and disease syndromes.
Research Activity
David Leslie is Co-Editor of Diabetes Metabolism Research and Reviews, and on the the Editorial board of Diabetes Care and Acta Diabetologica. He gave a Royal College of Physicians Lecture in 2005, was made Honorary Professor of Central South University, China, is Director of the European Consortium Action LADA, Director of the British Diabetic Twin Trust, a member of the NIH Advisory Board on the Prevention of Diabetes, a Trustee of the British Twin Trust and the Muirhead Trust.. His research involves studies using major patient resources (such as patients with adult-onset autoimmune disease and twins with diabetes), and molecular studies on these cases including collaborations with the Human Epigenome Consortium and the NIH in America . Recent studies have lead to identification of a genetic component to protein glycation using healthy and diabetic twins and the characterisation of latent onset diabetes of the adults following a major multi-million pound EU grant to Prof. Leslie. Recent studies have led to the development of novel vaccination-type therapies to limit the disease process in type 1 diabetes which are now proceeding to Phase 3 studies.
Key Publications
• Immune reactivity to glutamic acid decarboxylase 65 in stiff-man syndrome and type 1 diabetes mellitus. (2000). T. Lohmann, M. Hawa, RDG Leslie , R. Lane , J. Picard, M. Londei. The Lancet 356; 31-35.
• The levels of glycated haemoglobin are genetically determined even in type 1 diabetes. (2001). H.Snieder, P. Sawtell, J. Walker, T. Spector, RDG Leslie. Diabetes :12; 2858:2863
• Autoantibodies as predictors of disease (2001) RDG Leslie, P. Lipsky, A. L. Notkins. J Clin, Invest. 10: 1417-22.
• Level of an advanced glycated end product is genetically determined: a study of normal twins. (2003) RDG Leslie, H. Beyan, P. Sawtell , B. O. Boehm, T. D. Spector, H. Snieder. Diabetes, 9; 2441-4
• Age-dependent influences on the origins of autoimmune diabetes: evidence and implications. (2004) RDG Leslie, M. Delli Castelli. Diabetes; 12: 3033-40.
• Clinical Endocrinology and Diabetes (2005) S. Chew, R.D.G Leslie. Churchill Livingstone Elsevier
• Clinical review: Type 1 diabetes and latent autoimmune diabetes in adults: one end of the rainbow.(2006) Leslie RD, Williams R, Pozzilli P. J Clin Endocrinol Metab.;91(5):1654-9.
• Evidence for Independent Heritability of the Glycation Gap (Glycosylation
Gap) Fraction of HbA1c in Nondiabetic Twins (2006) RM Cohen, H Snieder, CJ
Lindsell, H Beyan, MI Hawa, S Blinko, R Edwards, TD Spector, RDG Leslie.
Diabetes Care, 2006 ; 29(8):1739-43
• Clinical evidence for the safety of GAD65 immunomodulation in adult-onset
autoimmune diabetes (2005) C. Agardh, C.M. Cilio, A. Lethagen, K. Lynch,
R.D.G. Leslie, M. Palmer, R.A. Harris, J.A. Robertson, A.Lernmark. Journal
of Diabetes and its Complications 19 2005, 238-246
• Altered monocyte COX response to lipopolysaccharide in type 1 diabetes. (2006) Beyan H , Goodier MR, Nawroly NS , Hawa MI, Bustin SA, Ogunkolade WB, Londei M, Yousaf N, Leslie RDG. Diabetes 2006 55(12):3439-45.
