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Professor Malcolm R. Alison PhD, DSc, FRCPath
Professor of Stem Cell Biology
Lead, Centre for Diabetes

 

 

 

Publications since 2001

  1. El-Bahrawy MA, Poulsom R, Jeffery R, Talbot I, Alison MR The expression of E-cadherin and catenins in sporadic colorectal carcinoma. Hum Pathol. 32, (2001), 1216-1224.
  2. Poulsom R, Forbes SJ, Hodivala-Dilke K, Ryan E, Wyles S, Navaratnarasah S, Jeffery R, Hunt T, Alison M, Cook T, Pusey C, Wright NA. Bone marrow contributes to renal parenchymal turnover and regeneration. J Pathol. 195, (2001), 229-235.
  3. El-Bahrawy M, Talbot I, Poulsom R, Alison M. Variable Nuclear Localization of alpha-Catenin in Colorectal Carcinoma. Lab Invest. 82(9), (2002),1167-74.
  4. El-Bahrawy MA, Talbot IC, Poulsom R, Jeffery R, Alison MR. The expression of E-cadherin and catenins in colorectal tumours from familial adenomatous polyposis patients. J Pathol. 198(1), (2002), 69-76.
  5. Brittan M, Hunt T, Jeffery R, Poulsom R, Forbes SJ, Hodivala-Dilke K, Goldman J, Alison MR, Wright NA. Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon. Gut 50(6), (2002), 752-757.
  6. Wells P, Gunn M, Alison M, Steel C, Golding M, Ranicar AS, Brady F, Osman S, Jones T, Price P. Assessment of proliferation in vivo using 2-[(11)c]thymidine positron emission tomography in advanced intra-abdominal malignancies. Cancer Res 2002; 62: 5698-5702.
  7. El-Bahrawy M, El-Masry N, Alison M, Poulsom R, Fallowfield M. Expression of beta-catenin in basal cell carcinoma. Br J Dermatol. 2003;148(5):964-970.
  8. Alison MR. Tissue-based stem cells: ABC transporter proteins take centre stage. J Pathol. 2003;200(5):547-550.
  9. Direkze N, Forbes SJ, Brittan M, Hunt T, Jeffery R, Preston SL, Poulsom R, Hodivala-Dilke K, Alison MR, Wright NA. Multiple organ engraftment by bone marrow-derived myofibroblasts and fibroblasts in bone marrow transplanted mice. Stem Cells 2003, 21 (5); 514-520.
  10. Forbes SJ, Russo FP, Rey V,Burra P, Rugge M, Wright NA, Alison MR. A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology 2004; 126: 955-963.
  11. El-Bahrawy M, Poulsom SR, Rowan AJ, Tomlinson IT, Alison MR. Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines. Int J Exp Pathol. 2004, 85:65-74.
  12. Morigi M, Imberti B, Zoja C, Corna D, Tomasoni S, Abbate M, Rottoli D, Angioletti S, Benigni A, Perico N, Alison M, Remuzzi G. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol. 2004;15(7):1794-1804.
  13. Direkze NC, Hodivala-Dilke K, Jeffrey R, Hunt T, Poulsom R, Oukrif D, Alison MR, Wright NA. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res 2004; 64: 8942-5.
  14. Di Campli C, Piscaglia AC, Pierelli L, Rutella S, Bonanno G, Alison MR, Mariotti A, Vecchio FM, Nestola M, Monego G, Michetti F, Mancuso S, Pola P, Leone G, Gasbarrini G, Gasbarrini A. A human umbilical cord stem cell rescue therapy in a murine model of toxic liver injury. Dig Liver Dis. 2004; 36: 603-13.
  15. Brittan M, Braun KM, Reynolds LE, Conti FJ, Reynolds AR, Poulsom R, Alison MR, Wright NA, Hodivala-Dilke KM. Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion.J Pathol. 2005; 205: 1-13.
  16. Fang TC, Alison MR, Cook HT, Jeffery R, Wright NA, Poulsom R. Proliferation of Bone Marrow-Derived Cells Contributes to Regeneration after Folic Acid-Induced Acute Tubular Injury. J Am Soc Nephrol. 2005; 16: 1723-1732.
  17. Brittan M, Chance V, Elia G, Poulsom R, Alison MR, Macdonald TT, Wright NA. A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts. Gastroenterology 2005;128:1984-1995.
  18. Albera C, Polak JM, Janes S, Griffiths MJ, Alison MR, Wright NA, Navaratnarasah S, Poulsom R, Jeffery R, Fisher C, Burke M, Bishop AE. Repopulation of human pulmonary epithelium by bone marrow cells: a potential means to promote repair. Tissue Eng. 2005; 11:1115-1121.
  19. Bigger BW, Siapati EK, Mistry A, Waddington SN, Nivsarkar MS, Jacobs L, Perrett R, Holder MV, Ridler C, Kemball-Cook G, Ali RR, Forbes SJ, Coutelle C, Wright NA, Alison MR, Thrasher AJ, Bonnet D, Themis MJ. Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Therapy 2006;13:117-126.
  20. Bamba S, Lee CY, Brittan M, Preston SL, Direkze NC, Poulsom R, Alison MR, Wright NA, Otto WR. Bone marrow ameliorates pathology in interleukin-10 knockout mice. Journal of Pathology 2006; 209:265-273.
  21. Vig P, Russo FP, Edwards RJ, Tadrous P, Wright NA, Thomas HC, Alison MR, Forbes SJ. The sources of parenchymal regeneration following chronic hepatocellular injury in mice. Hepatology 2006;43:316-324.
  22. Russo FP, Alison MR, Bigger BW, Amofah E, Florou A, Amin F, Bou-Gharios G, Jeffery R, Iredale JP, Forbes SJ. The bone marrow functionally contributes to liver fibrosis. Gastroenterology 2006; 130:1807-1821.
  23. Alison MR, Poulsom R, Brittan M, Schier S, Burkert J, Wright NA. Isolation of gut SP cells does not automatically enrich for stem cells. Gastroenterology 2006; 130: 1012-1013.
  24. Direkze NC, Jeffery R, Hodivala-Dilke K, Hunt T, Playford RJ, Elia G, Poulsom R, Wright NA, Alison MR. Bone marrow-derived stromal cells express lineage-related messenger RNA species. Cancer Research 2006; 66: 1265-1269.
  25. Brocker V, Langer F, Fellous TG, Mengel M, Brittan M, Bredt M, Milde S, Welte T, Eder M, Haverich A, Alison MR, Kreipe H, Lehmann U. Fibroblasts of Recipient Origin Contribute to Bronchiolitis Obliterans in Human Lung Transplants. Am J Respir Crit Care Med. 2006; 173:1276-1282.
  26. Gordon MY, Levicar N, Pai M, Bachellier P, Dimarakis I, Al-Allaf F, M'hamdi H, Thalji T, Welsh JP, Marley SB, Davis J, Dazzi F, Marelli-Berg F, Tait P, Playford R, Jiao L, Jensen S, Nicholls JP, Ayav A, Nohandani M, Farzaneh F, Gaken J, Dodge R, Alison M, Apperley JF, Lechler R, Habib NA. Characterisation and Application of Human CD34 Stem/Progenitor Cell Populations Mobilised into the Blood by G-CSF. Stem Cells. 2006; 24; 1822-1830.
  27. Alison, M. R. " Stem cells and the liver - An update" Liver (2001), 21, 367-373.
  28. Forbes S, Vig P, Poulsom R, Thomas H, Alison M. Hepatic stem cells. J Pathol. 202;197(4):510-518.
  29. Poulsom R, Alison MR, Forbes SJ, Wright NA. Adult stem cell plasticity. J Pathol. 2002;197(4):441-456.
  30. Alison MR, Poulsom R, Forbes S, Wright NA. An introduction to stem cells. J Pathol. 2002;197(4):419-423.
  31. Alison MR, Hunt T, Forbes SJ. Minichromosome maintenance (MCM) proteins may be pre-cancer markers. Gut 2002; 50(3):290-291.
  32. Forbes SJ, Vig P, Poulsom R, Wright NA, Alison MR. Adult stem cell plasticity: new pathways of tissue regeneration become visible. Clin Sci (Lond) 2002; 103(4):355-369.
  33. Alison MR. Liver regeneration with reference to stem cells. Semin Cell Dev Biol 2002; 13(6):385-387.
  34. Preston SL, Alison MR, Forbes SJ, Direkze NC, Poulsom R, Wright NA. The new stem cell biology: something for everyone. Mol Pathol. 2003, 56(2):86-96.
  35. Alison MR, Poulsom R, Otto WR, Vig P, Brittan M, Direkze NC, Preston SL, Wright NA. Plastic adult stem cells: will they graduate from the school of hard knocks? J Cell Sci. 2003; 116: 599-603.
  36. Poulsom R, Alison MR, Cook T, Jeffery R, Ryan E, Forbes SJ, Hunt T, Wyles S, Wright NA. Bone marrow stem cells contribute to healing of the kidney. J Am Soc Nephrol. 2003; 14(Suppl 1):S48-54.
  37. Alison MR. Characterization of the differentiation capacity of rat-derived hepatic stem cells. Seminars in Liver Disease 2003; 23: 325-336.
  38. Alison MR, Poulsom R, Otto WR, Vig P, Brittan M, Direkze NC, Lovell M, Fang TC, Preston SL, Wright NA. Recipes for adult stem cell plasticity: fusion cuisine or readymade? J Clin Path 2004; 57: 113-120.
  39. Alison MR, Vig P, Russo F, Bigger BW, Amofah E, Themis M, Forbes S. Hepatic stem cells: from inside and outside the liver? Cell Prolif. 2004; 37(1): 1-21.
  40. Fang TC, Alison MR, Wright NA, Poulsom R. Adult stem cell plasticity: will engineered tissues be rejected? Int J Exp Pathol. 2004;85(3):115-124.
  41. Alison MR. Liver cancer: the role of stem cells. Cell Proliferation 2005;38:407-421.
  42. Forbes SJ, Alison MR. Molecular Insights into Gastroenterology: Stem cell biology and the liver: current understanding and future prospects. Gut 2005.
  43. Alison MR, Brittan M, Lovell M, Wright NA. Markers of tissue-based adult stem cells. Handbook of Experimental Pharmacology 2006;174:185-227.
  44. Alison MR. Liver stem cells: implications for hepatocarcinogenesis. Stem Cell Reviews 2006;1(3).
  45. Alison MR, Lovell MJ, Direkze NC, Wright NA, Poulsom R. Stem cell plasticity and tumour formation. Eur. J. Cancer 2006; 42:1247-1256.
  46. Burkert J, Wright NA, Alison MR. Stem cells and cancer: an intimate relationship. J Pathol. 2006; 209:287-297.
  47. Direkze NC , Alison MR. Bone marrow and tumour stroma: an intimate relationship. Haematological Oncology 2006; 24:1-7.
  48. Forbes SJ, Alison MR. Side population (SP) cells: Taking center stage in regeneration and liver cancer? Hepatology. 2006 Jul;44(1):23-6.
  49. Alison, M.R. (2001) "Cancer". In "The Encyclopaedia of Life Sciences" Macmillan/Nature Publishing. www.els.net .
  50. Preston SL, Poulsom R, Jeffrey R, Goodlad RA, Mandir N, Elia G, Novelli M, Bodmer W, Tomlinson IP, Hunt T, Direktze N, Alison MR, Wright NA. Gastrointestinal stem cells: center stage in the origins of colorectal cancer, of gut lineages, and stem cell plasticity. In: 'Disease Progression and Carcinogenesis in the Gastrointestinal Tract, Galle PR, Schmidt WE and Wiedenmann B (eds), 2003, pp41-67. Kluwer Academic Publishers.
  51. Alison MR, Forbes SJ. (2005). Liver stem cells in persistent viral infection, liver regeneration and cancer. In 'Viral Hepatitis, 3 rd edition, pp 3-14. Thomas HC, Lemon S & Zuckermann A (eds). Blackwell Publishing, Oxford .
  52. Alison MR. Liver stem cells. In: 'Stem Cells: From Bench to Bedside' Bongso A and Lee EH (eds), July 2005. World Scientific Publishing Co., Singapore .
  53. Alison MR. Stem cells and transdifferentiation. Recent Advances in Histopathology 21, (2005), pp 89-104. Underwood J & Pignatelli M (eds). Royal Society of Medicine Press Ltd, London .
  54. Alison MR, Forbes SJ. (2005) Liver stem cells. In: Artificial Liver Support', (Henne-Bruns D, Buttenschon K, Fuchs M, Lohse AW [eds]). Falk Symposium 145, Springer, pp 105-131.
  55. Alison MR. (2005) An introduction to stem and progenitor cell biology. In: 'Stem Cell Repair and Regeneration, (Habib N, Gordon MY, Levicar N, Jiao L, Thomas-Black G, eds), pp 1-20. Imperial College Press, London .
  56. Alison MR. Liver cancer: a disease of stem cells? Panminerva Med. 2006; 48: 165-174.
  57. Tosh D, Shen CN, Alison MR , Sarraf CE, Slack JM. Copper deprivation in rats induces islet hyperplasia and hepatic metaplasia in the pancreas. Biol Cell. 2007: 99:37-44.
  58. Fellous TG, Guppy NJ, Brittan M, Alison MR . Cellular pathways to beta-cell replacement. Diabetes Metab Res Rev. 2007, 23: 87-99.
  59. Kallis Y, Alison MR , Forbes SJ. Bone marrow stem cells and liver disease. Gut. 2007; 56: 716-724.
  60. Yen TH, Alison MR , Cook HT, Jeffery R, Otto WR, Wright NA, Poulsom R. The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment. Cell Prolif. 2007, 40: 143-56.
  61. Brittan M, Alison MR , Schier S, Wright NA. Bone marrow stem cell-mediated regeneration in IBD: where do we go from here? Gastroenterology 2007,132: 1171-1173.
  62. Alison MR , Choong C, Lim S. Application of liver stem cells for therapy. Seminars in Cell and Developmental Biology 2007, 18: 819-826.
  63. Lin WR, Brittan M, Alison MR. The role of bone marrow derived cells in fibrosis. Cells Tissues and Organs 2008, 188(1-2):178-88.
  64. Mizrak D, Brittan M, Alison MR. CD133: molecule of the moment. J Pathol. 2008;
    214(1):3-9.
  65. Preston S, Leedham S, Oukrif D, Deheregoda M, Goodlad R, Poulsom R, Alison MR, Wright N, Novelli M. The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse. J Pathol. 2008; 214, 294-301.
  66. Walsh MJ, Fellous TG, Hammiche A, Lin WR, Fullwood NJ, Grude O, Bahrami F, Nicholson JM, Cotte M, Susini J, Pollock HM, Brittan M, Martin-Hirsch PL, Alison MR, Martin FL. FTIR Micro-spectroscopy Identifies Symmetric PO2- Modifications as a Marker of the Putative Stem Cell Region of Human Intestinal Crypts. Stem Cells. 2008, 26, 108-118.
  67. Fang TC, Otto WR, Jeffery R, Hunt T, Alison MR, Cook HT, Wright NA, Poulsom R. Exogenous bone marrow cells do not rescue non-irradiated mice from acute renal tubular damage caused by HgCl2, despite establishment of chimaerism and cell proliferation in bone marrow and spleen. Cell Prolif. 2008;41(4):592-606.
  68. Fang TC, Otto WR, Rao J, Jeffery R, Hunt T, Alison MR, Cook HT, Wright NA, Poulsom R. Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl 2 -induced acute tubular injury. Cell Prolif. 2008;41(4):575-91.
  69. Khoo CP, Pozzilli P, Alison MR. Endothelial progenitor cells and their potential therapeutic applications. Regen Med. 2008;3(6):863-76.
  70. Alison MR, Islam S, Lim S. Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly. J Pathol. 2009;217(2):282-98.
  71. Khoo CP, Valorani MG, Brittan M, Alison MR, Warnes G, Johansson U, Hawa M, Pozzilli P. Characterization of endothelial progenitor cells in the NOD mouse as a source for cell therapies. Diabetes Metab Res Rev. 2008;25(1):89-93.
  72. Alison MR, Islam S. Attributes of adult stem cells. J Pathol. 2009;217(2):144-60
  73. Alison MR. Stem cells in pathobiology and regenerative medicine. J Pathol. 2009;217(2):141-3.
  74. Jeffery R, Poulsom R, Alison MR. Sources of adult hepatic stem cells: haematopoietic. Methods Mol Biol. 2009;481:1-14.
  75. Alison MR, Lim S, Houghton JM. Bone marrow-derived cells and epithelial tumours: more than just an inflammatory relationship. Curr Opin Oncol. 2009;21(1):77-82.
  76. Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Taylor G, McDonald SA, Wright NA, Alison MR. Locating the stem cell niche and tracing hepatocyte lineages in human liver. Hepatology. 2009; 49: 1655-63.
  77. Fellous TG, McDonald SA, Burkert J, Humphries A, Islam S, De-Alwis NM, Gutierrez-Gonzalez L, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, El-Bahrawy M, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Day CP, Wright NA, Alison MR. A Methodological Approach To Tracing Cell Lineage In Human Epithelial Tissues. Stem Cells 2009; 27: 1410-1420.
    Walsh MJ, Hammiche A, Fellous TG, Nicholson JM, Cotte M, Susini J, Fullwood NJ, Martin-Hirsch PL, Alison MR, Martin FL. Tracking the cell hierarchy in the human intestine using biochemical signatures derived by mid-infrared microspectroscopy.
    Stem Cell Res. 2009 Feb 21. [Epub ahead of print]
  78. Alison MR, Islam S, Lin SML. Number crunching in the cancer stem cell market. Breast Cancer Treatment 2009; 11, 302.
  79. Alison MR, Islam S, Lin SML. Cell therapy for liver disease. Current Opinion in Molecular Therapeutics 2009; 11, 364-374.
  80. Le Brenne, Islam S, Alison MR. Stem cells and lung cancer: future therapeutic targets. Expert Opinion in Biological Therapeutics 2009; 9, 1127-1141.
  81. McDonald SA, Graham TA, Schier S, Wright NA, Alison MR. Stem cells and solid cancers. Virchows Arch. 2009, 455, 1-13.
  82. Alison MR. Stem cells and cancer in the aerodigestive tract. Eur J Cancer. 2009, 45 Suppl 1, 175-85.
  83. Alison MR, Islam S, Wright NA. Stem cells in cancer: instigators and propagators? J Cell Sci. 2010; 123: 2357-2368.
  84. Alison MR, Guppy NJ, Lim SM, Nicholson LJ. Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose? J Pathol. 2010; 222: 335-344.
  85. Alison MR, Lim SM, Nicholson LJ. Cancer stem cells; problems for therapy? J Pathol 2011; 223: 147-161.
  86. Alison MR, Lim SML, Nicholson LJ. Cancer stem cells: A moving drug target. International Drug Discovery 2010; October/November.
  87. Watson AR, Pitchford SC, Reynolds LE, Direkze N, Brittan M, Alison MR, Rankin S, Wright NA, Hodivala-Dilke KM. Deficiency of bone marrow 3-integrin enhances non-functional neovascularization. J Pathol. 2010; 220, 435-445.
  88. Alison MR, McDonald SA, Lin WR, Wright NA. Protection of mitochondrial genome integrity: A new stem cell property? Hepatology 2010, 354.
  89. Lin WR, Lim SA, McDonald SA, Graham T, Wright V, Peplow C, Humphries A, Kocher HM, Wright NA, Dhillon AP, Alison MR. The histogenesis of regenerative nodules in human liver cirrhosis. Hepatology 2010; 51, 1017-1026.
  90. Bortolomai I, Canevari S, Facetti I, De Cecco L, Castellano G, Zacchetti A, Alison MR, Miotti S. Tumor initiating cells: Development and critical characterization of a model derived from the A431 carcinoma cell line forming spheres in suspension. Cell Cycle. 2010 Mar 4;9(6). [Epub ahead of print]
  91. Perego M, Tortoreto M, Tragni G, Mariani L, Deho P, Carbone A, Santinami M, Patuzzo R, Mina PD, Villa A, Pratesi G, Cossa G, Perego P, Daidone MG, Alison MR, Parmiani G, Rivoltini L, Castelli C. Heterogeneous Phenotype of Human Melanoma Cells with In Vitro and In Vivo Features of Tumor-Initiating Cells. J Invest Dermatol. 2010; 130, 1877-1886.
  92. Valorani MG, Germani A, Otto WR, Harper L, Biddle A, Khoo CP, Lin WR, Hawa MI, Tropel P, Patrizi MP, Pozzilli P, Alison MR. Hypoxia increases Sca-1/CD44 co-expression in murine mesenchymal stem cells and enhances their adipogenic differentiation potential. Cell Tissue Res. 2010; 341: 111-120.
  93. Lorenzini S, Bird TG, Boulter L, Bellamy C, Samuel K, Aucott R, Clayton E, Andreone P, Bernardi M, Golding M, Alison MR, Iredale JP, Forbes SJ. Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Gut. 2010; 59: 645-654.
  94. Kallis YN, Robson AJ, Fallowfield JA, Thomas HC, Alison MR, Wright NA, Goldin RD, Iredale JP, Forbes SJ. Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response. Gut. 2010; 60: 525-533.
  95. Perego M, Alison MR, Mariani L, Rivoltini L, Castelli C. Spheres of influence in cancer stem cell biology. J Invest Dermatol. 2011;131: 546-547.

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