Home| Professor of Molecular Pharmacology |
Publications since 2001
• Falasca M, Hughes WE, Dominguez V, Sala G, Fostira F, Fang MQ, Cazzolli R, Shepherd PR, James DE, Maffucci T. The role of phosphoinositide 3-kinase C2 a in insulin signalling. J. Biol. Chem. 2007 282:28226-28236
• Maffucci T, Falasca M. (2007) Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma. Biochem Soc Trans. 35:229-230.
• Falasca M, Maffucci T. (2007) Role of class II phosphoinositide 3-kinase in cell signalling. Biochem Soc Trans. 35:211-214.
• Falasca M, Maffucci T. (2006) Emerging roles of phosphatidylinositol 3 monophosphate as a dynamic lipid second messenger. Arch Physiol Biochem. 112:274-284.
• Maffucci T., Piccolo E., Cumashi A., Iezzi M., Riley A.M., Saiardi A. Godage H.Y., Rossi C., Broggini M., Iacobelli S., Potter B.V.L., Innocenti P. and Falasca M. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by Inositol pentakisphosphate results in ant-angiogenic and anti-tumour effects. Cancer Res, 65:8339-8349.
• Maffucci, T., Cooke, F.T., Foster, F.M., Traer, C.J., Fry, M.J., and Falasca M. (2005) Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. J Cell Biol. 169:789-799.
• Piccolo E., Vignati S., Maffucci, T., Innominato P.F., Riley A.M., Potter B.V.L., Pandolfi P.P., Broggini M., Iacobelli S., Innocenti P. and Falasca M. ( 2004 ) Inositol Pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. Oncogene, 23:754-1765.
• Okigaki, M., Davis , C., Falasca, M. , Harroch, S., Felsenfeld, D.P., Sheetz, M.P, and Schlessinger, J. (2003) Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci USA , 100:10740-10745.
• Maffucci, T., Razzini, G., Ingrosso, A. Chen, H., Iacobelli, S., Sciacchitano, S., Quon, M.J. and Falasca, M. (2003) Role of Pleckstrin Homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate-3. Mol. End, 17:1568-1579.
• Maffucci, T., Brancaccio, A., Piccolo, E., Stein, R.C. and Falasca, M. (2003) Insulin induces phosphatidylinositol 3-phosphate formation through TC10 activation . EMBO J, 22:4178-89.
• Piccolo, E., Innominato, P.F., Mariggio, M.A., Maffucci, T., Iacobelli, S. and Falasca, M. (2002) The mechanism involved in the regulation of phospholipase Cgamma1 activity in cell migration. Oncogene, 21:6520-6529.
• Maffucci T, Falasca M. (2001) Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism. FEBS Lett. 506:173-179.
• Russo C, Gao Y, Mancini P, Vanni C, Porotto M, Falasca M, Torrisi MR, Zheng Y, Eva A. (2001) Modulation of oncogenic DBL activity by phosphoinositol phosphate binding to pleckstrin homology domain. J Biol Chem. 276:19524-19531.