Home| Professor of Molecular Medicine & Diabetes |
| Deputy Director (Research), Blizard Institute of Cell and Molecular Science |
Publications since 2001
• Chinnery,PF, Mowbray,C, Patel,SK, Elson,JL, Sampson,M, Hitman,GA, McCarthy,MI, Hattersley,AT, Walker,M: Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls. J Med Genet 44:e80, 2007
• Churchman,SM, Church,LD, Savic,S, Coulthard,LR, Hayward,B, Nedjai,B, Turner,MD, Mathews,RJ, Baguley,E, Hitman,GA, Gooi,HC, Wood,P, Emery,P, McDermott,MF: A novel TNFRSF1A splice mutation associated with increased NF-{kappa}B transcription factor activation in patients with TNF-receptor associated periodic syndrome (TRAPS). Ann Rheum Dis 2007
• Desai,M, Zeggini,E, Horton,VA, Owen,KR, Hattersley,AT, Levy,JC, Walker,M, Gillespie,KM, Bingley,PJ, Hitman,GA, Holman,RR, McCarthy,MI, Clark,A: An association analysis of the HLA gene region in latent autoimmune diabetes in adults. Diabetologia 50:68-73, 2007
• Frayling,TM, Timpson,NJ, Weedon,MN, Zeggini,E, Freathy,RM, Lindgren,CM, Perry,JR, Elliott,KS, Lango,H, Rayner,NW, Shields,B, Harries,LW, Barrett,JC, Ellard,S, Groves,CJ, Knight,B, Patch,AM, Ness,AR, Ebrahim,S, Lawlor,DA, Ring,SM, Ben-Shlomo,Y, Jarvelin,MR, Sovio,U, Bennett,AJ, Melzer,D, Ferrucci,L, Loos,RJ, Barroso,I, Wareham,NJ, Karpe,F, Owen,KR, Cardon,LR, Walker,M, Hitman,GA, Palmer,CN, Doney,AS, Morris,AD, Smith,GD, Hattersley,AT, McCarthy,MI: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889-894, 2007
• Gueorguiev,M, Wiltshire,S, Garcia,EA, Mein,C, Lecoeur,C, Kristen,B, Allotey,R, Hattersley,AT, Walker,M, O'rahilly,S, Froguel,P, Grossman,AB, McCarthy,MI, Hitman,GA, Korbonits,M: Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes. J Clin Endocrinol Metab 92:2201-2204, 2007
• Hitman,GA, Colhoun,H, Newman,C, Szarek,M, Betteridge,DJ, Durrington,PN, Fuller,J, Livingstone,S, Neil,HA: Stroke prediction and stroke prevention with atorvastatin in the Collaborative Atorvastatin Diabetes Study (CARDS). Diabet Med 24:1313-1321, 2007
• Marshall,C, Hitman,GA, Cassell,PG, Turner,MD: Effect of glucolipotoxicity and rosiglitazone upon insulin secretion. Biochem Biophys Res Commun 356:756-762, 2007
• Meirhaeghe,A, Sandhu,MS, McCarthy,MI, de,GP, Cottel,D, Arveiler,D, Ferrieres,J, Groves,CJ, Hattersley,AT, Hitman,GA, Walker,M, Wareham,NJ, Amouyel,P: Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. Hum Mol Genet 16:1343-1350, 2007
• Nedjai,B, Hitman,GA, Yousaf,N, Chernajovsky,Y, Stjernberg-Salmela,S, Pettersson,T, Ranki,A, Hawkins,PN, Arkwright,PD, McDermott,MF, Turner,MD: Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 58:273-283, 2007
• Owen,KR, Groves,CJ, Hanson,RL, Knowler,WC, Shuldiner,AR, Elbein,SC, Mitchell,BD, Froguel,P, Ng,MC, Chan,JC, Jia,W, Deloukas,P, Hitman,GA, Walker,M, Frayling,TM, Hattersley,AT, Zeggini,E, McCarthy,MI: Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects. Diabetes 56:879-883, 2007
• Raikou,M, McGuire,A, Colhoun,HM, Betteridge,DJ, Durrington,PN, Hitman,GA, Neil,HA, Livingstone,SJ, Charlton-Menys,V, Fuller,JH: Cost-effectiveness of primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes: results from the Collaborative Atorvastatin Diabetes Study (CARDS). Diabetologia 50:733-740, 2007
• Ramachandran,A, Snehalatha,C, Sivasankari,S, Hitman,GA, Vijay,V: Parental influence on the spectrum of type 2 diabetes in the offspring among Indians. J Assoc Physicians India 55:560-562, 2007
• Sandhu,MS, Weedon,MN, Fawcett,KA, Wasson,J, Debenham,SL, Daly,A, Lango,H, Frayling,TM, Neumann,RJ, Sherva,R, Blech,I, Pharoah,PD, Palmer,CN, Kimber,C, Tavendale,R, Morris,AD, McCarthy,MI, Walker,M, Hitman,G, Glaser,B, Permutt,MA, Hattersley,AT, Wareham,NJ, Barroso,I: Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 39:951-953, 2007
• The Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678, 2007
• Turner,MD, Fulcher,FK, Jones,CV, Smith,BT, Aganna,E, Partridge,CJ, Hitman,GA, Clark,A, Patel,YM: Calpain facilitates actin reorganization during glucose-stimulated insulin secretion. Biochem Biophys Res Commun 352:650-655, 2007
• Wellcome Trust Case Control Consortium & The Australo-Anglo-American Spondylitis Consortium: Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 39:1329-1337, 2007
• Winckler,W, Weedon,MN, Graham,RR, McCarroll,SA, Purcell,S, Almgren,P, Tuomi,T, Gaudet,D, Bostrom,KB, Walker,M, Hitman,G, Hattersley,AT, McCarthy,MI, Ardlie,KG, Hirschhorn,JN, Daly,MJ, Frayling,TM, Groop,L, Altshuler,D: Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes 56:685-693, 2007
• Zeggini,E, Weedon,MN, Lindgren,CM, Frayling,TM, Elliott,KS, Lango,H, Timpson,NJ, Perry,JR, Rayner,NW, Freathy,RM, Barrett,JC, Shields,B, Morris,AP, Ellard,S, Groves,CJ, Harries,LW, Marchini,JL, Owen,KR, Knight,B, Cardon,LR, Walker,M, Hitman,GA, Morris,AD, Doney,AS, McCarthy,MI, Hattersley,AT: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341, 2007
• Aganna,E, Burrin,JM, Hitman,GA, Turner,MD: Involvement of calpain and synaptotagmin Ca2+ sensors in hormone secretion from excitable endocrine cells. J Endocrinol 190:R1-R7, 2006
• Castleden,HA, Shields,B, Bingley,PJ, Williams,AJ, Sampson,M, Walker,M, Gibson,JM, McCarthy,MI, Hitman,GA, Levy,JC, Hattersley,AT, Vaidya,B, Pearson,ER: GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes. Diabet Med 23:834-838, 2006
• Desai,M, Zeggini,E, Horton,VA, Owen,KR, Hattersley,AT, Levy,JC, Hitman,GA, Walker,M, Holman,RR, McCarthy,MI, Clark,A: The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults. Diabetes 55:1890-1894, 2006
• Freathy,RM, Weedon,MN, Shields,B, Hitman,GA, Walker,M, McCarthy,MI, Hattersley,AT, Frayling,TM: Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population. JOP 7:295-302, 2006
• Freathy,RM, Weedon,MN, Melzer,D, Shields,B, Hitman,GA, Walker,M, McCarthy,MI, Hattersley,AT, Frayling,TM: The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. BMC Med Genet 7:51, 2006
• Gloyn,AL, Mackay,DJ, Weedon,MN, McCarthy,MI, Walker,M, Hitman,G, Knight,BA, Owen,KR, Hattersley,AT, Frayling,TM: Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach. Diabetes 55:2272-2276, 2006
• Gordon,AC, Waheed,U, Hansen,TK, Hitman,GA, Garrard,CS, Turner,MW, Klein,NJ, Brett,SJ, Hinds,CJ: Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock 25:88-93, 2006
• Groves,CJ, Zeggini,E, Walker,M, Hitman,GA, Levy,JC, O'rahilly,S, Hattersley,AT, McCarthy,MI, Wiltshire,S: Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate. Diabetes 55:1884-1889, 2006
• Groves,CJ, Zeggini,E, Minton,J, Frayling,TM, Weedon,MN, Rayner,NW, Hitman,GA, Walker,M, Wiltshire,S, Hattersley,AT, McCarthy,MI: Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 55:2640-2644, 2006
• Neil,HA, DeMicco,DA, Luo,D, Betteridge,DJ, Colhoun,HM, Durrington,PN, Livingstone,SJ, Fuller,JH, Hitman,GA: Analysis of efficacy and safety in patients aged 65-75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS). Diabetes Care 29:2378-2384, 2006
• Ogunkolade,WB, Boucher,BJ, Bustin,SA, Burrin,JM, Noonan,K, Mannan,N, Hitman,GA: Vitamin D metabolism in peripheral blood mononuclear cells is influenced by chewing "betel nut" (Areca catechu) and vitamin D status. J Clin Endocrinol Metab 91:2612-2617, 2006
• Patel,S, Minton,JA, Weedon,MN, Frayling,TM, Ricketts,C, Hitman,GA, McCarthy,MI, Hattersley,AT, Walker,M, Barrett,TG: Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population. Diabetologia 49:1209-1213, 2006
• Singh,R, Pearson,E, Avery,PJ, McCarthy,MI, Levy,JC, Hitman,GA, Sampson,M, Walker,M, Hattersley,AT: Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes. Diabetologia 49:1876-1880, 2006
• Sze,C, Gould,D, Hitman,G, Chowdhury,TA: Relapsing and remitting insulin requiring diabetes: type 1 or type 2? J R Soc Med 99:415-416, 2006
• Weedon,MN, McCarthy,MI, Hitman,G, Walker,M, Groves,CJ, Zeggini,E, Rayner,NW, Shields,B, Owen,KR, Hattersley,AT, Frayling,TM: Combining information from common type 2 diabetes risk polymorphisms improves disease prediction. PLoS Med 3:e374, 2006
• Weedon,MN, Shields,B, Hitman,G, Walker,M, McCarthy,MI, Hattersley,AT, Frayling,TM: No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians. Diabetes 55:3175-3179, 2006
• Wiltshire,S, Bell,JT, Groves,CJ, Dina,C, Hattersley,AT, Frayling,TM, Walker,M, Hitman,GA, Vaxillaire,M, Farrall,M, Froguel,P, McCarthy,MI: Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans. Ann Hum Genet 70:726-737, 2006
• Zeggini,E, Damcott,CM, Hanson,RL, Karim,MA, Rayner,NW, Groves,CJ, Baier,LJ, Hale,TC, Hattersley,AT, Hitman,GA, Hunt,SE, Knowler,WC, Mitchell,BD, Ng,MC, O'Connell,JR, Pollin,TI, Vaxillaire,M, Walker,M, Wang,X, Whittaker,P, Xiang,K, Jia,W, Chan,JC, Froguel,P, Deloukas,P, Shuldiner,AR, Elbein,SC, McCarthy,MI: Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q. Diabetes 55:2541-2548, 2006
• Boucher,BJ, Timms,PM, Hitman,GA: Association between fasting glucose and C-reactive protein in middle-aged subjects. Diabet Med 22:508-509, 2005
• Chinnery,PF, Elliott,HR, Patel,S, Lambert,C, Keers,SM, Durham,SE, McCarthy,MI, Hitman,GA, Hattersley,AT, Walker,M: Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes. Lancet 366:1650-1651, 2005
• Colhoun,HM, Betteridge,DJ, Durrington,PN, Hitman,GA, Neil,HA, Livingstone,SJ, Thomason,MJ, Fuller,JH: Rapid emergence of effect of atorvastatin on cardiovascular outcomes in the Collaborative Atorvastatin Diabetes Study (CARDS). Diabetologia 48:2482-2485, 2005
• Maeda,S, Tsukada,S, Kanazawa,A, Sekine,A, Tsunoda,T, Koya,D, Maegawa,H, Kashiwagi,A, Babazono,T, Matsuda,M, Tanaka,Y, Fujioka,T, Hirose,H, Eguchi,T, Ohno,Y, Groves,CJ, Hattersley,AT, Hitman,GA, Walker,M, Kaku,K, Iwamoto,Y, Kawamori,R, Kikkawa,R, Kamatani,N, McCarthy,MI, Nakamura,Y: Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J Hum Genet 50:283-292, 2005
• Marshall,C, Hitman,GA, Partridge,CJ, Clark,A, Ma,H, Shearer,TR, Turner,MD: Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells. Mol Endocrinol 19:213-224, 2005
• Newman,DJ, Mattock,MB, Dawnay,AB, Kerry,S, McGuire,A, Yaqoob,M, Hitman,GA, Hawke,C: Systematic review on urine albumin testing for early detection of diabetic complications. Health Technol Assess 9:iii-163, 2005
• Turner,MD, Cassell,PG, Hitman,GA: Calpain-10: from genome search to function. Diabetes Metab Res Rev 21:505-514, 2005
• Weedon,MN, Owen,KR, Shields,B, Hitman,G, Walker,M, McCarthy,MI, Hattersley,AT, Frayling,TM: A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population. Diabetes 54:2487-2491, 2005
• Yousaf,N, Gould,DJ, Aganna,E, Hammond,L, Mirakian,RM, Turner,MD, Hitman,GA, McDermott,MF, Chernajovsky,Y: Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-kappaB activation. Arthritis Rheum 52:2906-2916, 2005
• Zeggini,E, Rayner,W, Morris,AP, Hattersley,AT, Walker,M, Hitman,GA, Deloukas,P, Cardon,LR, McCarthy,MI: An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets. Nat Genet 37:1320-1322, 2005
• Zeggini,E, Groves,CJ, Parkinson,JR, Halford,S, Owen,KR, Frayling,TM, Walker,M, Hitman,GA, Levy,JC, O'rahilly,S, Hattersley,AT, McCarthy,MI: Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes. Diabetologia 48:2013-2017, 2005
• Zeggini,E, Parkinson,JR, Halford,S, Owen,KR, Walker,M, Hitman,GA, Levy,JC, Sampson,MJ, Frayling,TM, Hattersley,AT, McCarthy,MI: Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples. Diabet Med 22:1696-1700, 2005
• Aganna,E, Hawkins,PN, Ozen,S, Pettersson,T, Bybee,A, McKee,SA, Lachmann,HJ, Karenko,L, Ranki,A, Bakkaloglu,A, Besbas,N, Topaloglu,R, Hoffman,HM, Hitman,GA, Woo,P, McDermott,MF: Allelic variants in genes associated with hereditary periodic fever syndromes as susceptibility factors for reactive systemic AA amyloidosis. Genes Immun 5:289-293, 2004
• Allotey,RA, Mohan,V, McDermott,MF, Deepa,R, Premalatha,G, Hassan,Z, Cassell,PG, North,BV, Vaxillaire,M, Mein,CA, Swan,DC, O'Grady,E, Ramachandran,A, Snehalatha,C, Sinnot,PJ, Hemmatpour,SK, Froguel,P, Hitman,GA: The EIF2AK3 gene region and type I diabetes in subjects from South India. Genes Immun 5:648-652, 2004
• Boucher,BJ, Hitman,GA: The vitamin D receptor gene variant and physical activity predicts fasting blood glucose levels in healthy young men. Diabet Med 21:803-804, 2004
• Colhoun,HM, Betteridge,DJ, Durrington,PN, Hitman,GA, Neil,HA, Livingstone,SJ, Thomason,MJ, Mackness,MI, Charlton-Menys,V, Fuller,JH: Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 364:685-696, 2004
• Gordon,AC, Lagan,AL, Aganna,E, Cheung,L, Peters,CJ, McDermott,MF, Millo,JL, Welsh,KI, Holloway,P, Hitman,GA, Piper,RD, Garrard,CS, Hinds,CJ: TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study. Genes Immun 5:631-640, 2004
• Hitman,GA, Sudagani,J: Searching for genes in diabetes and the metabolic syndrome. Int J Clin Pract Suppl 3-8, 2004
• Jackson,AE, Cassell,PG, North,BV, Vijayaraghavan,S, Gelding,SV, Ramachandran,A, Snehalatha,C, Hitman,GA: Polymorphic variations in the neurogenic differentiation-1, neurogenin-3, and hepatocyte nuclear factor-1alpha genes contribute to glucose intolerance in a South Indian population. Diabetes 53:2122-2125, 2004
• Liew,CF, Groves,CJ, Wiltshire,S, Zeggini,E, Frayling,TM, Owen,KR, Walker,M, Hitman,GA, Levy,JC, O'rahilly,S, Hattersley,AT, Johnston,DG, McCarthy,MI: Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism. Diabetologia 47:2168-2175, 2004
• Mills,GW, Avery,PJ, McCarthy,MI, Hattersley,AT, Levy,JC, Hitman,GA, Sampson,M, Walker,M: Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes. Diabetologia 47:732-738, 2004
• Owen,KR, Evans,JC, Frayling,TM, Hattersley,AT, McCarthy,MI, Walker,M, Hitman,GA: Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes. Diabetologia 47:957-958, 2004
• Thomason,MJ, Colhoun,HM, Livingstone,SJ, Mackness,MI, Betteridge,DJ, Durrington,PN, Hitman,GA, Neil,HA, Fuller,JH: Baseline characteristics in the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with Type 2 diabetes. Diabet Med 21:901-905, 2004
• Weedon,MN, Owen,KR, Shields,B, Hitman,G, Walker,M, McCarthy,MI, Love-Gregory,LD, Permutt,MA, Hattersley,AT, Frayling,TM: Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population. Diabetes 53:3002-3006, 2004
• Wiltshire,S, Frayling,TM, Groves,CJ, Levy,JC, Hitman,GA, Sampson,M, Walker,M, Menzel,S, Hattersley,AT, Cardon,LR, McCarthy,MI: Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24. Diabetes 53:855-860, 2004
• Zeggini,E, Parkinson,J, Halford,S, Owen,KR, Frayling,TM, Walker,M, Hitman,GA, Levy,JC, Sampson,MJ, Feskens,EJ, Hattersley,AT, McCarthy,MI: Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset. Diabetes 53:3319-3322, 2004
• Aganna,E, Hammond,L, Hawkins,PN, Aldea,A, McKee,SA, van Amstel,HK, Mischung,C, Kusuhara,K, Saulsbury,FT, Lachmann,HJ, Bybee,A, McDermott,EM, La,RM, Arostegui,JI, Campistol,JM, Worthington,S, High,KP, Molloy,MG, Baker,N, Bidwell,JL, Castaner,JL, Whiteford,ML, Janssens-Korpola,PL, Manna,R, Powell,RJ, Woo,P, Solis,P, Minden,K, Frenkel,J, Yague,J, Mirakian,RM, Hitman,GA, McDermott,MF: Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes. Arthritis Rheum 48:2632-2644, 2003
• Barnett,AH, Grant,PJ, Hitman,GA, Mather,H, Pawa,M, Robertson,L, Trelfa,A: Rosiglitazone in Type 2 diabetes mellitus: an evaluation in British Indo-Asian patients. Diabet Med 20:387-393, 2003
• Frayling,TM, Wiltshire,S, Hitman,GA, Walker,M, Levy,JC, Sampson,M, Groves,CJ, Menzel,S, McCarthy,MI, Hattersley,AT: Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11. Diabetes 52:1857-1863, 2003
• Gloyn,AL, Weedon,MN, Owen,KR, Turner,MJ, Knight,BA, Hitman,G, Walker,M, Levy,JC, Sampson,M, Halford,S, McCarthy,MI, Hattersley,AT, Frayling,TM: Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52:568-572, 2003
• Groves,CJ, Wiltshire,S, Smedley,D, Owen,KR, Frayling,TM, Walker,M, Hitman,GA, Levy,JC, O'rahilly,S, Menzel,S, Hattersley,AT, McCarthy,MI: Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility. Diabetes 52:1300-1305, 2003
• Murphy,HC, Regan,G, Bogdarina,IG, Clark,AJ, Iles,RA, Cohen,RD, Hitman,GA, Berry,CL, Coade,Z, Petry,CJ, Burns,SP: Fetal programming of perivenous glucose uptake reveals a regulatory mechanism governing hepatic glucose output during refeeding. Diabetes 52:1326-1332, 2003
• North,BV, Curtis,D, Cassell,PG, Hitman,GA, Sham,PC: Assessing optimal neural network architecture for identifying disease-associated multi-marker genotypes using a permutation test, and application to calpain 10 polymorphisms associated with diabetes. Ann Hum Genet 67:348-356, 2003
• Snehalatha,C, Ramachandran,A, Satyavani,K, Sivasankari,S, Nanditha,R, Vijay,V, Hitman,GA: Evaluation of the beta cell response by C-peptide measurement in parents of children with type I diabetes. J Assoc Physicians India 51:927-928, 2003
• Soedamah-Muthu,SS, Colhoun,HM, Thomason,MJ, Betteridge,DJ, Durrington,PN, Hitman,GA, Fuller,JH, Julier,K, Mackness,MI, Neil,HA: The effect of atorvastatin on serum lipids, lipoproteins and NMR spectroscopy defined lipoprotein subclasses in type 2 diabetic patients with ischaemic heart disease. Atherosclerosis 167:243-255, 2003
• Weedon,MN, Schwarz,PE, Horikawa,Y, Iwasaki,N, Illig,T, Holle,R, Rathmann,W, Selisko,T, Schulze,J, Owen,KR, Evans,J, Del Bosque-Plata,L, Hitman,G, Walker,M, Levy,JC, Sampson,M, Bell,GI, McCarthy,MI, Hattersley,AT, Frayling,TM: Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. Am J Hum Genet 73:1208-1212, 2003
• Aganna,E, Zeharia,A, Hitman,GA, Basel-Vanagaite,L, Allotey,RA, Booth,DR, Hawkins,PN, Thacker,C, Syndercombe-Court, McDermott,MF: An Israeli Arab patient with a de novo TNFRSF1A mutation causing tumor necrosis factor receptor-associated periodic syndrome. Arthritis Rheum 46:245-249, 2002
• Aganna,E, Martinon,F, Hawkins,PN, Ross,JB, Swan,DC, Booth,DR, Lachmann,HJ, Bybee,A, Gaudet,R, Woo,P, Feighery,C, Cotter,FE, Thome,M, Hitman,GA, Tschopp,J, McDermott,MF: Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum 46:2445-2452, 2002
• Cassell,PG, Jackson,AE, North,BV, Evans,JC, Syndercombe-Court, Phillips,C, Ramachandran,A, Snehalatha,C, Gelding,SV, Vijayaravaghan,S, Curtis,D, Hitman,GA: Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians. Diabetes 51:1622-1628, 2002
• Chowdhury,ZM, McDermott,MF, Davey,S, Hassan,Z, Sinnott,PJ, Hemmatpour,SK, Sherwin,S, Ali,L, Aganna,E, Allotey,RA, North,BV, Cassell,PG, zad Khan,AK, Hitman,GA: Genetic susceptibility to fibrocalculous pancreatic diabetes in Bangladeshi subjects: a family study. Genes Immun 3:5-8, 2002
• Colhoun,HM, Thomason,MJ, Mackness,MI, Maton,SM, Betteridge,DJ, Durrington,PN, Hitman,GA, Neil,HA, Fuller,JH: Design of the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with type 2 diabetes. Diabet Med 19:201-211, 2002
• Hassan,Z, Mohan,V, Ali,L, Allotey,R, Barakat,K, Faruque,MO, Deepa,R, McDermott,MF, Jackson,AE, Cassell,P, Curtis,D, Gelding,SV, Vijayaravaghan,S, Gyr,N, Whitcomb,DC, Khan,AK, Hitman,GA: SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. Am J Hum Genet 71:964-968, 2002
• Ogunkolade,BW, Boucher,BJ, Fairclough,PD, Hitman,GA, Dorudi,S, Jenkins,PJ, Bustin,SA: Expression of 25-hydroxyvitamin D-1-alpha-hydroxylase mRNA in individuals with colorectal cancer. Lancet 359:1831-1832, 2002
• Ogunkolade,BW, Boucher,BJ, Prahl,JM, Bustin,SA, Burrin,JM, Noonan,K, North,BV, Mannan,N, McDermott,MF, DeLuca,HF, Hitman,GA: Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes 51:2294-2300, 2002
• Penfornis,A, Tuomilehto-Wolf,E, Faustman,DL, Hitman,GA: Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes. Hum Immunol 63:61-70, 2002
• Timms,PM, Mannan,N, Hitman,GA, Noonan,K, Mills,PG, Syndercombe-Court, Aganna,E, Price,CP, Boucher,BJ: Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? QJM 95:787-796, 2002
• Wiltshire,S, Frayling,TM, Hattersley,AT, Hitman,GA, Walker,M, Levy,JC, O'rahilly,S, Groves,CJ, Menzel,S, Cardon,LR, McCarthy,MI: Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes. Am J Hum Genet 70:543-546, 2002
• Aganna,E, Aksentijevich,I, Hitman,GA, Kastner,DL, Hoepelman,AI, Posma,FD, Zweers,EJ, McDermott,MF: Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance. Eur J Hum Genet 9:63-66, 2001
• Barakat,K, Hitman,GA: Genetic susceptibility to macrovascular complications of type 2 diabetes mellitus. Best Pract Res Clin Endocrinol Metab 15:359-370, 2001
• Barakat,K, Kennon,S, Hitman,GA, Aganna,E, Price,CP, Mills,PG, Ranjadayalan,K, North,B, Clarke,H, Timmis,AD: Interaction between smoking and the glycoprotein IIIa P1(A2) polymorphism in non-ST-elevation acute coronary syndromes. J Am Coll Cardiol 38:1639-1643, 2001
• Evans,JC, Frayling,TM, Cassell,PG, Saker,PJ, Hitman,GA, Walker,M, Levy,JC, O'rahilly,S, Rao,PV, Bennett,AJ, Jones,EC, Menzel,S, Prestwich,P, Simecek,N, Wishart,M, Dhillon,R, Fletcher,C, Millward,A, Demaine,A, Wilkin,T, Horikawa,Y, Cox,NJ, Bell,GI, Ellard,S, McCarthy,MI, Hattersley,AT: Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am J Hum Genet 69:544-552, 2001
• Kennon,S, Barakat,K, Hitman,GA, Price,CP, Mills,PG, Ranjadayalan,K, Cooper,J, Clark,H, Timmis,AD: Angiotensin-converting enzyme inhibition is associated with reduced troponin release in non-ST-elevation acute coronary syndromes. J Am Coll Cardiol 38:724-728, 2001
• Metcalfe,KA, Hitman,GA, Rowe,RE, Hawa,M, Huang,X, Stewart,T, Leslie,RD: Concordance for type 1 diabetes in identical twins is affected by insulin genotype. Diabetes Care 24:838-842, 2001
• Wiltshire,S, Hattersley,AT, Hitman,GA, Walker,M, Levy,JC, Sampson,M, O'rahilly,S, Frayling,TM, Bell,JI, Lathrop,GM, Bennett,A, Dhillon,R, Fletcher,C, Groves,CJ, Jones,E, Prestwich,P, Simecek,N, Rao,PV, Wishart,M, Bottazzo,GF, Foxon,R, Howell,S, Smedley,D, Cardon,LR, Menzel,S, McCarthy,MI: A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet 69:553-569, 2001