Home| Non-clinical Lecturer in Neurogastroenterology |
Contact details:
| Tel: | +44 20 7882 2639 |
| Fax: | +44 20 7882 2103 |
| Email: | d.bulmer@qmul.ac.uk |
| Address: | Centre for Digestive Diseases, |
Biography
BSc Pharmacology: University of Manchester.
PhD Physiology: Royal Free and University College Medical School.
2002-2004: Neurogastroenterology Group, Department of Biomedical Sciences, University of Sheffield.
2005-2007: Neurology and Gastrointestinal Centre of Excellence in Drug Discovery, GlaxoSmithKline.
2007-2009: Immuno-Inflammation Centre of Excellence in Drug Discovery, GlaxoSmithKline.
Research Activity
Dr Bulmer’s research interests lie in the processing of sensory information from the gastrointestinal tract and the development of novel drugs for the treatment of irritable bowel syndrome (IBS). Previous and continuing areas of interest include the role of TRPV1 channels and 5-HT2B receptors in visceral pain, and sensory nerve signalling from the gastrointestinal tract in normal and disease states. Current research includes the identification of a novel thalamic response to visceral pain (with Prof Qasim Aziz) and the development of, in vitro, human visceral sensory nerve recordings (with Mr Charlie Knowles and Dr Mark Baker). Dr Bulmer is the recipient of an MRC skills gap fellowship and consortium member of the intestinal proteases: opportunities for drug discovery (IPODD) FP-7 research programme.
Key Publications
• van den Wijngaard RM, Klooker TK, Welting O, Stanisor OI, Wouters MM, van der Coelen D, Bulmer DC, Peeters PJ, Aerssens J, de Hoogt R, Lee K, de Jonge WJ, Boeckxstaens GE. Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats. Neurogastroenterology & Motility (2009) in press
• Hyland NP, Julio-Pieper M, O'Mahony SM, Bulmer DC, Lee K, Quigley EM, Dinan TG, Cryan JF. A distinct subset of submucosal mast cells undergoes hyperplasia following neonatal maternal separation: a role in visceral hypersensitivity? Gut. (2009) 58(7):1029-30.
• Beyak MJ, Bulmer DCE, Sellers D., Grundy D. Impairment of rectal afferent mechanosensitivity in experimental diabetes in the rat. Neurogastroenterology & Motility (2009) 21(6): 678-681.
• Van den Wijngaard RM, Klooker TK, Welting O. Coelen D, Bulmer DC, Lee K, de Jong WJ, Boeckxstaens GE (2009). Possible role for TRPV1 in neomycin induced inhibition of visceral hypersensitivity in rat. Neurogastroenterol Motil (in press).
• Beyak MJ, Bulmer DCE, Sellers D, Grundy D (2009). Impairment of rectal mechanosensitivity in experimental diabetes in the rat. Neurogastroenterol Motil 21(6) 678-681.
• Bulmer DCE, Coelho AM, Winchester WJ (2007). Approaches to the treatment of visceral pain. Drug Discovery Today: Therapeutic Stratergies 4(3) 171-176.
• Beyak MJ, Bulmer DC, Jiang W, Keating C, Rong W, Grundy D. (2006). Extrinsic sensory afferent nerves innervating the gastrointestinal tract. In Physiology of the gastrointestinal tract. Elsevier Press Ed Johnson LR.
• Murray CD, Booth CE, Bulmer DC, Kamm MA, Emmanuel AV, Winchester WJ. (2006). Ghrelin augments afferent response to distension in rat isolated jejunum. Neurogastroenterol Motil. 18(12):1112-20.
• Bulmer DC, Jiang W, Hicks GA, Davis JB, Winchester WJ, Grundy D. (2005). Vagal selective effects of ruthenium red on the jejunal afferent fibre response to ischaemia in the rat. Neurogastroenterol Motil. 17(1):102-11.
