Home| Reader in Clinical Paediatric Gastroenterology |
Contact details:
| Tel: | +44 20 7882 2642 |
| Fax: | +44 20 7375 2103 |
| Email: | n.m.croft@qmul.ac.uk |
| Address: |
Centre for Digestive Diseases, |
Biography
After starting his clinical training as a paediatrician in Edinburgh and Glasgow he entered the speciality of paediatric gastroenterology whilst working for his PhD in the field mucosal immunology (awarded 1997) in the GI unit at Edinburgh University (with the late Prof Anne Ferguson). Since his appointment in 1998 his work has largely been in leading and supporting clinical and translational research in the field of paediatric gastroenterology in addition to his teaching roles as the course organizer for the MSc in Gastroenterology and member of the undergraduate paediatric teaching programme.
Research Activity
His research interests are based around clinical and translational research focussing on paediatric gastroenterological diseases such as inflammatory bowel disease, celiac disease, food allergy, gastro-oesophageal reflux and gastrointestinal infections. This has recently included examining the underlying genetics of growth failure in IBD and the growth response to enteral nutrition in children.
He is a recently appointed (2006) co-director of the London SENCE Medicines for Children Local Research Network which has been funded to support the development and running of randomized controlled trials of treatments in children and increase the evidence base for treatments.
Academic Activity
His teaching role lies in organizing the highly regarded MSc in gastroenterology which supports research both via projects run within the course and by attracting quality students to study for higher degrees. As a member of the Human Development Systems planning unit he is a member of the undergraduate paediatric teaching team.
Key Publications
• A. Sawczenko, O. Azooz, J. Paraszczuk, M. Idestrom , N. M. Croft, M. O. Savage, A. B.Ballinger*, and Ian R.Sanderson. Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the -174 IL-6 G/C polymorphism in children PNAS 102(37): 13260-13265, 2005. http://www.pnas.org/cgi/reprint/0503589102v1
• Croft,N.M. and Hodges,M. IgM: The mucosal response in acute diarrheal disease of infants. Scand.J.Gastroenterol. 40:965-971, 2005
• K. Bannerjee, C. Camacho-Hubner, K. Babinska, K. M. Dryhurst, R. Edwards, M. O. Savage, I. R. Sanderson, and N. M. Croft. Anti-inflammatory and growth-stimulating effects precede nutritional restitution during enteral feeding in Crohn disease. J.Pediatr.Gastroenterol.Nutr. 38 (3):270-275, 2004
. • J. C. Escher, European Collaborative Research Group on Budesonide in Paediatric IBD . Budesonide versus prednisolone for the treatment of active Crohn's disease in children: a randomized, double-blind, controlled, multicentre trial. Eur.J.Gastroenterol.Hepatol. 16 (1):47-54, 2004.
• G. Monteleone, J. Holloway, V. M. Salvati, S. L. Pender, P. D. Fairclough, N. M. Croft, and T. T. MacDonald. Activated STAT4 and a functional role for IL-12 in human Peyer's patches. J.Immunol. 170 (1):300-307, 2003.
• G. Monteleone, A. Kumberova, N. M. Croft, C. McKenzie, H. W. Steer, and T. T. MacDonald. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J.Clin.Invest 108 (4):601-609, 2001.
• Croft, N.M. and Ferguson , A. High intraluminal fluid flow increases intestinal IgA output. Scand.J.Gastroenterol. 35 (7):726-731, 2000.
• Smyth RL, Croft NM, O'Hea U, Marshall TG, Ferguson A. Intestinal inflammation in cystic fibrosis. Arch Dis Child 2000; 82(5):394-399.
• Croft NM, Howatson AG, Ling SC, Nairn L, Evans TJ, Weaver LT. Microvillous inclusion disease: an evolving condition. J Pediatr Gastroenterol Nutr 2000; 31(2):185-189.
• Croft NM , Marshall TG, Ferguson A. Gut inflammation in children with cystic fibrosis on high-dose enzyme supplements. Lancet 1995; 346:1265-1267.
