Home| Honorary, Sir James Black Professor of Gastrointestinal Biology and Trials |
Contact details:
| Tel: | +44 20 7882 7191 |
| Fax: | +44 20 7882 2187 |
| Email: | j.a.jankowski@qmul.ac.uk |
| Address: | Centre for Digestive Diseases, |
Biography
Personal: Janusz is married and has three wonderful children.
Hobbies: European history and vegetarian food (specialty: ‘Stanislaw Stack/Stosu’).
Career: Janusz is an international leader in mucosal biology, translational medicine and cancer prevention and has won prestigious prizes most notably the Sir Avery Jones Prize (one of the youngest recipients) and is now the Sir James Black Professor. He trained in Scotland undertaking gastro-oesophageal clinical research. He then worked on colorectal biology at the University of London with Prof Sir Nicholas Wright. He was then awarded the Betz Fellowship to study genetics of GI disease at the University of California San Francisco with Prof Young Kim. He was promoted to titular Professor at the University of Birmingham followed by an Emeritus Professorship at the University of Leicester. He was then awarded the James Black Fellowship at the University of Oxford to work with the Noble Laureate and Prof Doug Altman in gastrointestinal cancer prevention. His lab group have now returned to the University of London to the pre-eminent GI Research Unit, in the Centre for Digestive Diseases at Barts and The London School of Medicine and Dentistry. His clinical passion however remains GI cancer prevention at the renowned Digestive Disease Clinical Centre in Leicester, UK.
Leadership: Prof Jankowski is a member of many national medicine committees including NICE (chair GI Advisory Group), NCRN as well as the editorial boards of several international journals and is also chair of the education committee British Society of Gastroenterology. He is also editor of best selling textbooks in science and medicine with related national courses.
Research Activity
1. chemoprevention of GI cancer (AspECT/WASP trials)- fully recruited and in follow up.
2. cancer surveillance of the GI tract (BOSS/BEAT trials) - recruiting/set up.
3. population genetics especially predisposition to GI disease & cancer (ChOPIN/IPOD trials)- Genome Wide Assessment Study preliminary result expected 2009.
4. translational research and novel cancer therapies (Handel/COG trials) - recruiting.
5. molecular cell biology/stem cell biology of Barrett's metaplasia and colitis (SAINT trial) - completed report due 2009.
Implications for health: identification of targets for global screening and drug development.
Current Grants: CRUK, NCRI, HTA/NHS/Dept of Health, Wellcome Trust & Industry » £10m.
Major Collaborations: include CRUK, Oxford University, NCI and McMaster University
Key Publications
• Greaves LC, Preston S, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D, Leedham SJ, Deheragoda M, Sasieni P, Novelli M, Jankowski JAZ, Turnbull D, Wright NA, McDonald SAC. Mitochondrial DNA mutations are established in human colonic stem cells and mutated clones expand by crypt fission. Proc Natl Acad Sciences USA 2006;103:714-9.
• Sharma P, Dent J, Armstrong D, Bergman J, Gossner L, Hoshihara Y, Jankowski J, Junghard O, Lundell L, Tytgat G, Vieth M. The development and validation of an endoscopic grading system for Barrett’s esophagus – the Prague C and M criteria. Gastroenterology 2006;131:1392-9.
• Anderson M, Harrison R, Atherfold P, Campbell M, Darnton S, Obszynska J, Jankowski J. Met receptor signalling: a key effector in esophageal adenocarcinoma. Clin Cancer Res 2006;12:5936-43.
• Harrison R, Perry I, Haddadin W, McDonald S, Bryan R, Abrams K, Sampliner R, Talley N, Moayyedi P, Jankowski J. Detection of intestinal metaplasia in Barrett’s esophagus: an observational comparator study suggests the need for eight biopsies to diagnose intestinal metaplasia. Am J Gastroenterol 2007:102:1154-61.
• McDonald S, Greaves LC, Gutierrez-Gonzalaz L, Rodriguez-Justo M, Deheragoda M, Leedham SJ, Taylor RW, Lee CY, Preston SL, Lovell M, Hunt T, Elia G, Oukrit D, Harrison R, Novelli M, Mitchell I, Stoker DL, Turnbull D, Jankowski JA, Wright N. Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells. Gastroenterology 2008;134:500-510.
• Milicic A, Harrison LA, Goodlad RA, Hardy RG, Nicholson AM, Presz M, Sieber O, Santander S, Pringle JH, Mandir N, East P, Obszynska J, Sanders S, Piazeulo E, Shaw J, Harrison R, Tomlinson IP, McDonald SAC, Wright NA, Jankowski JAZ. Ectopic expression of P-Cadherin correlates with promoter hypomethylation early in colon carcinogenesis and enhanced intestinal crypt fission in vivo. Cancer Research 2008;68:7760-8.
• Leedham SJ, Graham TA, Oukrif D, McDonald SA, Rodriguez-Justo M, Harrison RF, Shepherd NA, Novelli MR, Jankowski JA, Wright NA. Clonality, founder mutations and field cancerization in ulcerative colitis-associated neoplasia. Gastroenterology 2009 136:542-50
• Jack Cuzick, Florian Otto, John A Baron, Powel H Brown, John Burn, Peter Greenwald, Janusz Jankowski, Carlo La Vecchia, Frank Meyskens, Hans Jörg Senn, Michael Thun. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. Lancet Oncol 2009;10:501-7
