Home| Reader in Tropical Gastroenterology |
Contact details:
| Tel: | +44 20 7882 2643 |
| Fax: | +44 20 7375 2103 |
| Email: | m.p.kelly@qmul.ac.uk |
| Address: |
Centre for Digestive Diseases, |
Biography
Paul Kelly is Reader in Tropical Gastroenterology in the University of London and Honorary Lecturer in the University of Zambia (UNZA). Originally from Cumbria, he qualified from Brasenose College, Oxford, and the London Hospital Medical College (as it then was) and trained in internal medicine and gastroenterology in London (Whipps Cross, Charing Cross, Whittington Hospitals). He then spent time working in Monze District Hospital in Zambia and came to Barts & The London to develop a research programme relating to intestinal infection in the tropics under Prof Michael Farthing. He has been co-Director of the Tropical Gastroenterology and Nutrition Group in the University of Zambia School of Medicine in Lusaka for over 10 years and now divides his time between London and Lusaka.
Research Activity
His interests are in the epidemiology of intestinal infections, the interaction between nutrition and immunology of the gut, and clinical trials of antiparasitic chemotherapy. His current research is funded by a Wellcome Trust Senior Fellowship and in a large randomized controlled trial in Lusaka seeks to answer the question: is innate defence in the small intestine dependent on micronutrient status?
See also:
Antimicrobial Peptide Primer Sequences [PDF]
T cell and Cytokine Gene Primer Sequences [PDF]
Key Publications
• Kelly P, Bajaj-Elliott M, Katubulushi M, Zulu I, Poulsom R, Feldman RA, Bevins CL, Dhaliwal W. Reduced gene expression of intestinal a -defensins predicts diarrhoea in a cohort of Zambian adults. J Infect Dis 2006; 193 : 1464-1470.
• Turner AK, Beavis JC, Stephens JC, Greenwood J, Gewert C, Thomas N, Deary A, Casula G, Daley A, Kelly P, Randall R, Darsley MJ. Construction and phase I clinical evaluation of the safety and immunogenicity of a candidate Enterotoxigenic Escherichia coli vaccine strain expressing colonisation factor antigen CFA/I. Infect Immun 2006; 74 : 1062-1071.
• Kelly P, Menzies I, Crane R, Zulu I, Nickols C, Feakins R, Mwansa J, Mudenda V, Katubulushi M, Greenwald S, Farthing MJG. Responses of small intestinal architecture and function over time to environmental factors in a tropical population. Am J Trop Med Hyg 2004; 70 : 412-419.
• Kelly P, Feakins R, Domizio P, Murphy J, Bevins CL, Wilson J, McPhail G, Bajaj-Elliot M, Poulsom R, Dhaliwal W. Paneth cell granule depletion in the human small intestine under infective and nutritional stress. Clin Exp Immunol 2004; 135 : 303-309.
• Dhaliwal W, Bajaj-Elliott M, Kelly P. Intestinal defensin gene expression in human populations. Molec Immunol 2003; 40 : 469-475.
• Amadi BC, Mwiya M, Musuku J, Watuka A, Sianongo S, Ayoub A, Kelly P. Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Lancet 2002; 360 : 1375-1380.
• Kelly P, Jack D, Naeem A, Pollok R, Mandanda B, Klein N, Turner M, Farthing MJG. Mannose Binding Lectin is a contributor to mucosal defence against Cryptosporidium parvum in AIDS patients. Gastroenterology 2000; 119 : 1236-1242.
• Nchito M, Kelly P, Sianongo S, Luo NP, Feldman RA, Farthing MJG, Baboo KS. Cryptosporidiosis in urban Zambian children: an analysis of risk factors. Am J Trop Hyg 1998; 59 : 435-437.
• Kelly P, Nchito M, Baboo KS, Ndubani P, Okeowo NP, Luo NP, Feldman RA, Farthing MJG. Cryptosporidiosis in adults in Lusaka, Zambia, and its relationship to oocyst contamination of drinking water. J Infect Dis 1997; 176 : 1120-1123.
• Kelly P, Lungu F, Keane E, Baggaley R, Kazembe F, Pobee JOM, Farthing MJG. Albendazole chemotherapy for treatment of diarrhoea in patients with AIDS in Zambia: a randomised double blind controlled trial. BMJ 1996: 312 : 1187-1191.
