Home| Clinical Senior Lecturer in Colorectal Surgery |
| Honorary Consultant Surgeon |
Contact details:
| Tel: | +44 20 7377 7449 |
| Fax: | +44 20 7377 7346 |
| Email: | c.h.knowles@qmul.ac.uk |
| Address: | Academic Surgical Unit, |
Biography
Charles Knowles undertook his preclinical training at Cambridge University and then moved to the London Hospital Medical College , qualifying in 1992. He quickly progressed with a career in surgery, passing the FRCS examination ( London ) in 1996. Prior to specialist training, he undertook a considerable body of research based at Barts & the London , and funded by the Royal College of Surgeons of England . During this time, he was awarded the degree of PhD at the University of London entitled 'clinical and aetiological studies in slow transit constipation'. He continued to actively participate in research during Specialist Registrar training (General Surgery) in the North-East Thames Region in the role of Clinical Lecturer in Academic Surgery. After successfully completing the final Intercollegiate Specialty Boards Examination in General Surgery (sub-specialty: Colorectal) he entered the Specialist Register in 2005. In September 2006 he was appointed Senior Lecturer in Colorectal Surgery on the basis of a prestigious award from HEFCE partnered by Honorary Consultant appointments at Barts and the London and the Homerton University NHS Foundation Trusts. His main clinical interest is in the management of benign coloproctological conditions.
Research Activity
Main research interests are :
• Neuromuscular pathological aspects of gastrointestinal motility disorders
• The molecular basis of gut sensorimotor dysfunction, particularly in relation to visceral hypersensitivity and pain
• The role of autoantibody-mediated disease in gut motility disorders
• The role of clinical tests of colorectal physiology in guiding therapy
Key Publications
• Knowles CH , Nickols CD, Scott SM, Bennett NI, de Oliveira RB, Chimelli L, Feakins R, Williams NS, Martin JE. Secondary smooth muscle degeneration with inclusion bodies in slow transit constipation. J Pathol 2001; 193 : 390-7.
• Facer P, Knowles CH , King RH, Thomas PK, Misra P, Tam PKH, Williams NS, Anand P. Trk C: a common marker of developmental abnormalities in Hirschsprung's disease and idiopathic slow transit constipation? Br J Surg 2001 ; 88 : 545-52 .
• Yiangou Y, Facer P, Dyer NHC, Chan CLH, Knowles CH , Williams NS, Anand P. Increased Capsaicin Receptor VR1-immunoreactivity in inflamed human bowel. Lancet 2001; 357 :1338-9 .
• Knowles CH , Lang B, Clover L, Scott SM, Vincent A, Martin JE. A role for autoantibodies in some cases of acquired non-paraneoplastic gut dysmotility. Scand J Gastroenterol, 2002; 37 : 166-70.
• Chen B, Knowles CH , Scott SM, Anand P, Williams NS, Milbrandt J, Tam PTH. Idiopathic slow transit constipation and megacolon are not associated with Neurturin mutations. Neurogastroenterol Motil 2002; 14 : 513-517.
• Scott SM, Knowles CH , Picon L, Yazaki E, Lunnis PJ, Wingate DL. Automated quantitative analysis of nocturnal jejunal motor activity identifies abnormalities in individuals and subgroups of patients with slow transit constipation. Am J Gastroenterol 2003 ; 98 : 1123-34.
• Knowles CH , Nickols CD, Feakins R, Martin JE. A systematic analysis of polyglucosan bodies in the human gastrointestinal tract in health and disease. Acta Neuropathol 2003 ; 105 : 410-13.
• Knowles CH , Silk DBA, Darzi A, Feakins R, Raimundo AH, Veress B, Crompton T, Lindberg G, Martin JE. Deranged smooth muscle alpha-actin: a biomarker of intestinal pseudo-obstruction. A controlled multinational case series. Gut 2004 ; 53 : 1583-89.
• Scott SM, Knowles CH , Wang D, Yazaki E, Picon L, Wingate DL, Lindberg G. The nocturnal jejunal migrating motor complex: defining normal ranges by study of 51 healthy adult volunteers and meta-analysis. Neurogastro Motil 2006 ; 18 : 927-35.
• Loosemore M, Knowles CH , Whyte GP.Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies. BMJ . 2007; 335: 809-813.
• Zarate N, Knowles CH , Lunniss PJ, Williams NS, Scott SM. Scintigraphic pattern of colonic transit does not differentiate between isolated slow-transit constipation and coexistent rectal evacuatory disorder. Am J Gastroenterol 2007 (epub ahead of print).
• Knowles CH , Aziz Q. Visceral hypersensitivity in non-erosive reflux disease. In press: Gut 2007 (epub ahead of print).
