Home| Clinical Senior Lecturer and Consultant in Gastroenterology |
Contact details:
| Tel: | +44 20 7377 7443 |
| Fax: | +44 20 7377 7441 |
| Email: | James.lindsay@bartsandthelondon.nhs.uk |
| Address: |
Centre for Digestive Diseases, |
Biography
I studied medicine at Cambridge and Oxford Universities before coming to the Hammersmith Hospital to do my basic medical training. I undertook a PhD in the immunology of Crohn's disease at Imperial College , before finishing Gastroenterology specialist training at Chelsea and Westminster Hospital and St Mark's Hospital. I have been a consultant Gastroenterologist at Barts and the London NHS trust since 2004. After my PhD I continued research into the role of dendritic cells in Crohn's disease with a focus on their manipulation with prebiotic dietary therapies. I am a senior lecturer at QMUL and am PI for a multicentre trial of prebiotics in Crohn's disease funded by a grant from the Broad foundation.
Research Activity
My PhD investigated the role of novel immunoregulatory therapies in animal models of crohn's disease including IL-10 gene therapy. Current research activity focuses on manipulating the intestinal microbiota with prebiotics as a therapy for Crohn's disease. I also collaborate with Dr A Stagg to investigate the role of intestinal and peripheral 'gut homing' dendritic cells in both disease pathogenesis and predicting response to therapies.
Key Publications
• Lindsay JO , Whelan K, Stagg AJ, Gobin P, Omar Al Hassi H, Rayment N, Kamm M, Knight S, Forbes A. The clinical, microbiological and immunological effects of fructo-oligosaccharide in patients with Crohn's disease. Gut , 2006. 55 (3):348-355.
• Lindsay JO , Sandison A, Cohen P, Brennan FM, Hodgson HJF. IL-10 gene therapy is therapeutic for Dextran sodium sulfate induced colitis. Digestive Diseases and Sciences , 2004; 49: 1327-1334.
• Lindsay JO , Ciesielski CJ, Scheinin T, Brennan FM, Hodgson HJ. The local delivery of adenoviral vectors encoding murine interleukin-10 induces colonic IL-10 production and is therapeutic for murine colitis. Gut , 2003; 52: 363-369.
• Lindsay JO , van Montfrans C, Brennan FM, van Deventer SJH, Drillenburg P, Hodgson HJF, te Velde AA, Rodriguez Pena MS. IL-10 gene therapy ameliorates TNBS induced colitis. Gene Therapy , 2002; 9: 1715-21.
• Lindsay JO , Ciesielski CJ, Scheinin T, Hodgson HJF, Brennan FM. The prevention and treatment of murine colitis using adenoviral vectors encoding interleukin-10. Journal of Immunology , 2001; 166: 7625-7633.
