Home| Lecturer in Gastroenterology |
Contact details:
| Tel: | +44 20 7882 7205 |
| Fax: | +44 20 7882 2178 |
| Email: | s.a.mcdonald@qmul.ac.uk |
| Address: |
Centre for Digestive Diseases, |
Biography
After achieving his PhD under Prof Tom MacDonald (ICMS), Dr McDonald spent several years researching inflammatory bowel disease and the immunology of infectious diseases of the gut. This eventually led him to work on stem cell biology within the human gastrointestinal tract with Professor Sir Nicholas Wright (ICMS and Cancer Research UK) and Professor Janusz Jankowski (ICMS and Leicester University Hospital) and has been working on this since 2004. He re-joined Barts and the London in November 2008.
Research Activity
Dr McDonald is interested in how DNA mutations take hold within the intestinal crypt and gastric gland and the mechanisms of how they spread through the gastrointestinal tract. He also has an active interest in the development of gastrointestinal cancers from premalignant conditions such as intestinal metaplasia of the human stomach and Barrett’s oesophagus. He is currently investigating how the competition between cells with different mutations seen in these conditions interact leading to cancer. He is also developing methods to locate the stem cell niche and tracing cell lineage in various tissues within the human body.
Key Publications
• Fellous TG, McDonald SAC, Burkert J*, Humphries A, De-Alwis NMW, Gutierrez–Gonzalez L, Tadrous P, Elia G, Chinnery PF, Day CP, Kocher HM, Bhattacharya S, Mears L, Turnbull DM, Greaves LC, Wright NA, Alison MR. Locating the stem cell niche and tracing cell lineage in human epithelial tissues: implications for the origins of human tumors. 2009 (In press, Stem Cells.).
• Gutierrez-Gonzalez L, Deheragoda M, Elia G, Jankowski JAZ, Wright NA and McDonald SAC. Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations. 2009. J. Pathol. 217(4):489-496
• Leedham SJ, Graham TA, Oukrif D, McDonald SAC, Rodriguez-Justo M, Harrison R, Novelli MR, Jankowski JAZ, and Wright NA. Clonality, founder mutations and field cancerization in human ulcerative colitis-associated neoplasia. 2009. Gastroenterology 136:542-550
• Milic A, Goodlad R, Harrison L-A, Hardy RG, Nicholson A, Presz M, Sieber O, Pringle JH, Mandir N, East P, Santander S, Obszynska J, Sanders S, Piazuelo E, Shaw J, Harrison R, Tomlinson IP, McDonald SAC, Wright NA and Jankowski JAZ. Ectopic expression of P-Cadherin correlates with CDH3 promoter hypomethylation in colorectal cancer and enhanced intestinal crypt fission in mice. 2008. Cancer Research 68(19):7760-7768
• Leedham SJ, Preston SL, McDonald SAC, Poller D, Jankowski JA and Wright NA. The origin of metaplastic glandular epithelium and individual crypt genetic heterogeneity in human Barrett's esophagus. 2008. Gut 57: 1041-1048.
• McDonald SAC, Greaves LC, Gutierrez-Gonzalez L, Lovell M, Deheragoda M, Leedham SJ, Taylor RW, Lee C-Y, Rodriguez-Justo M, Preston SL, Hunt T, Elia G, Oukrif D, Novelli M, Mitchell I, Stoker DL, Turnbull DM, Jankowski JA, and Wright NA. Mechanism of Field Cancerization in the Human Stomach: The Expansion and Spread of Mutated Gastric Stem Cells. 2008. Gastroenterology 134:500-510.
• Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW and Tomlinson IP. 2007. Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell 11(4):311-9.
• McDonald SAC, Preston SL, Lovell MJ, Wright NA and Jankowski JAZ. 2006. Mechanisms of Disease: From stem cells to colorectal cancer. Nature Clinical Practice (Gastroenterology and Hepatology)3(5) :1-7.
• McDonald SAC, Preston SL, Greaves LC, Lovell MJ, Turnbull DM, Jankowski JAZ, Wright NA. 2006. From cells to clones – Mitochondrial DNA mutations show us the way. Cell Cycle, 5(8): e1-e4.
• Greaves LC, Preston SL, Taylor RW, Barron MJ, Sasieni P, Oukrif D, Leedham SJ, Novelli MR, Jankowski JAZ, Turnbull DM, Wright NA and McDonald SAC. 2006. Mitochondrial DNA mutations are established in human colonic stem cells and mutated clones expand by crypt fission. Proc. Natl. Acad. Sci. 103(3):714-9
