Clinical Senior Lecturer in Colorectal Surgery

Honorary Consultant Surgeon

 

 

 

Publications since 2001

•  Cheng W, Au DKK, Knowles CH , Anand P, Tam PKH. Hirschsprung's Disease: A more generalised neuropathy?. J Pediatr Surg 2001; 36 : 296-300 .

•  Knowles CH , Nickols CD, Scott SM, Bennett NI, de Oliveira RB, Chimelli L, Feakins R, Williams NS, Martin JE. Secondary smooth muscle degeneration with inclusion bodies in slow transit constipation. J Pathol 2001; 193 : 390-7.

•  Knowles CH , Scott SM, Lunniss PJ. Slow transit constipation: a disorder of the pelvic autonomic nerves?. Dig Dis Sci 2001; 46 : 389-401.

•  Scott SM, Knowles CH , Newell M, Garvie N, Lunniss PJ. Scintigraphic assessment of colonic transit in patients with slow transit constipation arising de novo and following pelvic surgery or childbirth. : Br J Surg 2001; 88 : 405-411 .

•  Facer P, Knowles CH , King RH, Thomas PK, Misra P, Tam PKH, Williams NS, Anand P. Trk C: a common marker of developmental abnormalities in Hirschsprung's disease and idiopathic slow transit constipation? Br J Surg 2001 ; 88 : 545-52 .

•  Yiangou Y, Facer P, Dyer NHC, Chan CLH, Knowles CH , Williams NS, Anand P. Increased Capsaicin Receptor VR1-immunoreactivity in inflamed human bowel. Lancet 2001; 357 :1338-9 .

•  Yiangou Y, Facer P, Smith J, Sangameswaran L, Eglen R, Birch R, Knowles CH , Williams NS, Anand P. Acid-sensing ion channels ASIC-1,-2 and -3 in human enteric and sensory neurons: increased ASIC-3 immunoreactivity in inflamed intestine. Eur J Gastroenterol Hepatol 2001 13 : 891-6. Comment in : Eur J Gastroenterol Hepatol . 2001: 13 : 885-8.

•  José de Souza L, Sampietre SN, Assis RS, Knowles CH , Moreira Leite KR, Jancar S, Monteiro da Cunha JE, Machado MCC. Effect of Platelet-activating factor antagonists (BN-52021, WEB-2170 and BB-882 on bacterial translocation in acute pancreatitis. J Gastrointest Surg 2001; 5 : 364-370.

•  Yiangou Y, Facer P, Baecker PA, Ford AP, Knowles CH , Chan CL, Williams NS, Anand P. ATP-gated ion channel P2X(3) is increased in human inflammatory bowel disease. Neurogastroenterol Motil. 2001; 13 : 365-9.

•  Chan CLH, Scott SM, Knowles CH , Fajobi OA, Lunniss PJ, Williams NS. Exaggerated rectal adaptation-another cause of outlet obstruction. Colorect Dis 2001; 2 : 140-2.

•  Facer P, Knowles CH , Tam PKH, Ford AP, Dyer N, Baecker PA, Anand P. Novel capsaicin (VR1) and purinergic (P2X3) receptors in Hirschsprung's intestine. J Pediatr Surg 2001; 36 : 1679-84.

•  Knowles CH , Lang B, Clover L, Scott SM, Vincent A, Martin JE. A role for autoantibodies in some cases of acquired non-paraneoplastic gut dysmotility. Scand J Gastroenterol, 2002; 37 : 166-70.

•  Knowles CH , Scott SM, Legg PE, Allison ME, Lunniss PJ. Level of classification performance of KESS (symptom scoring system for constipation) validated in a prospective series of 105 patients . Dis Colon Rectum 2002; 45 : 842.

•  Chen B, Knowles CH , Scott SM, Anand P, Williams NS, Milbrandt J, Tam PTH. Idiopathic slow transit constipation and megacolon are not associated with Neurturin mutations. Neurogastroenterol Motil 2002; 14 : 513-517.

•  Porrett T, Knowles CH , Lunniss PJ. An audit of the treatment of anal fissure in a district general hospital: creation of a treatment algorithm for nurse-led management. Colorectal Dis 2003; 5 : 63-72.

•  Scott SM, Knowles CH , Picon L, Yazaki E, Lunnis PJ, Wingate DL. Automated quantitative analysis of nocturnal jejunal motor activity identifies abnormalities in individuals and subgroups of patients with slow transit constipation. Am J Gastroenterol 2003 ; 98 : 1123-34.

•  Chan CLH, Scott MS, Birch MJ, Knowles CH , Williams NS, Lunniss PJ. Rectal heat thresholds - a novel test of the sensory afferent pathway. Dis Colon Rectum 2003 ; 46 : 590-5.

•  Knowles CH , Nickols CD, Feakins R, Martin JE. A systematic analysis of polyglucosan bodies in the human gastrointestinal tract in health and disease. Acta Neuropathol 2003 ; 105 : 410-13.

•  Knowles CH , Scott SM, Rayner C, Glia A, Lindberg G, Kamm MA, Lunniss PJ. Idiopathic slow transit constipation: an almost exclusively female disorder. Dis Colon Rectum 2003; 46 : 1716-7.

•  Gladman MA, Knowles CH , Payne JG. Intraoperative culture in appendicitis: historical practice challenged. Ann Royal Coll Surg Eng 2004; 86 : 196-201.

•  Dworkin L, Chan CHL, Knowles CH , Scott SM, Williams NS, Lunniss PJ. Anal sphincter morphology in patients with full thickness rectal prolapse. Dis Colon Rectum 2004; 47 : 198-203 .

•  Knowles CH , Silk DBA, Darzi A, Feakins R, Raimundo AH, Veress B, Crompton T, Lindberg G, Martin JE. Deranged smooth muscle alpha-actin: a biomarker of intestinal pseudo-obstruction. A controlled multinational case series. Gut 2004 ; 53 : 1583-89.

•  Dworkin L, Knowles CH , Scott SM, Williams NS, Lunniss PJ. Characterisation and symptomatology in rectal intussusception. Dis Colon Rectum 2005 ; 48 : 824-31.

•  Hammond TM, Knowles CH , Porrett T, Lunniss PJ. The Snug Seton. Short and medium term results of slow fistulotomy for idiopathic anal fistulae. Colorect Dis 2006; 8 : 328-337.

•  Maroney NL, Knowles CH . Innovation and teamwork: introducing multidisciplinary team ward rounds. Nursing Management 2006; 13 : 28-31.

•  Konig T, Knowles CH , West A, Wilson A, Cross F. Stabbing: data support public perception. BMJ 2006; 333 : 652.

•  Scott SM, Knowles CH , Wang D, Yazaki E, Picon L, Wingate DL, Lindberg G. The nocturnal jejunal migrating motor complex: defining normal ranges by study of 51 healthy adult volunteers and meta-analysis. Neurogastro Motil 2006 ; 18 : 927-35.

•  Donaldson J, Knowles CH , Lobo MD, Clark SK. Rectus sheath haematoma associated with low molecular weight heparin: a case series. Ann Royal Coll Surg England 2007; 89 : 309-312.

•  Murphy J, Hammond TM, Knowles CH , Scott SM, Lunniss PJ, Williams NS. Does Anastomotic Technique Influence Anorectal Function after Sphincter-Saving Rectal Cancer Resection? A Systematic Review of Evidence from Randomized Trials. In press J Am. Col. Surg .

•  Murphy J, Hammond TM, Knowles CH , Scott SM, Lunniss PJ, Williams NS. JACS CME-1 Featured Article, Volume 204, April 2007. J Am Coll Surg 2007; 204: 728-31.

•  Loosemore M, Knowles CH , Whyte GP.Amateur boxing and risk of chronic traumatic brain injury: systematic review of observational studies. BMJ . 2007; 335: 809-813.

•  Zarate N, Knowles CH , Lunniss PJ, Williams NS, Scott SM. Scintigraphic pattern of colonic transit does not differentiate between isolated slow-transit constipation and coexistent rectal evacuatory disorder. Am J Gastroenterol 2007 (epub ahead of print).

•  Knowles CH , Aziz Q. Visceral hypersensitivity in non-erosive reflux disease. In press: Gut 2007 (epub ahead of print).

•  Bowen S, Bird MM, Deinhardt K, Price KM, Baker CS, Robson JC, Swash M, Shamsuddin W, Kawar S, El-Tawil T, Hoyle A, Nickols CD, Knowles CH , Pullen AH, Luthert PJ, Weller RO, Hafezparest M, Franklin RJM, Revesz T, King RHM, Berninghausen O, Fisher EMC, Schiavo G, Martin JE. Phagocytosis of cell and non-cell debris by neurons in vitro and in vivo. Eur J Neurosci 2007; 25 : 2947-55.

•  Tornblom H, Lang B, Clover L, Knowles CH , Vincent A, Lindberg G.Autoantibodies in patients with gut motility disorders and enteric neuropathy. Scand J Gastroenterol
2007; 42 : 1289-93.

Manuscripts in press

•  Knowles CH . New horizons in the pathogenesis of gastrointestinal neuromuscular disorders . In press: J Ped Gastroenterol Nutr.

•  Harrison SC , Knowles CH , Beejay U, Williams NS. Obscure gastrointestinal bleeding in a young woman. In press Gut .

•  Gooneratne M, Facer P, Knowles CH , Frye J, Chan C, Anand P, Williams NS. Elevated rectal mucosal substance P levels in patients with faecal incontinence are normalised by successful sacral nerve stimulation. In press Br J Surg 2006 .

•  Zarate N, Knowles CH , Lunniss PJ, Williams NS, Scott SM. Scintigraphic pattern of colonic transit does not differentiate between isolated slow-transit constipation and coexistent rectal evacuatory disorder. In press: Am J Gastroenterol 2007.

•  Gladman MA, Knowles CH . Advances in the diagnosis, pathophysiology and management of idiopathic megabowel. In press: Colorectal Dis 2007 .

•  Irving PM, Macey MG, Knowles CH , Liyanage SH, Dorudi S, Williams NS, Rampton DS. Platelet leucocyte aggregation occurs in the mesenteric vasculature with inflammatory bowel disease . In press Eur J Gastroenetrol Hepatol 2007 .

•  Knowles CH , Aziz Q. Visceral hypersensitivity in non-erosive reflux disease . In press: Gut 2007.

•  Murphy J, Williams NS, Knowles CH . The Anterior Perineal PlanE for ultra low Anterior Resection (the APPEAR technique): a pilot study. In press Ann Surg 2008.

•  Knowles CH, de Giorgio R. Observations on a vestigial organ: a potential surrogate for enteric neuromesenchymal disease. In press Neurogastro motil 2008.

• Knowles CH, Veress B, Tornblom H, Wallace S, Paraskevas P, Darzi A,  Martin JE, Nyborg B, Lindberg G. Clinical utility and safety of laparoscopic full-thickness bowel biospy: european multicentre experience. In press Neurogastro motil 2008.

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