Home| Professor of Cancer Genetics |
Publications since 2001
• Sengupta N, MacFie TS, Pennington D, Mcdonald T, Silver A. (2010). Cancer immunoediting and spontaneous tumour regression. Pathology Research and Practice, 15:1-8.
• Mcdonald S, Silver A. (2009). On target? Strategies and progress in developing therapies for colorectal cancer targeted against WNT signalling. Colorectal Diseases. Dec 8th.
• Mcdonald S, Silver A. (2009). Wnt5a: opposing roles in cancer. British J. Cancer, 101:209-14.
• Howarth K, Ranta S, Winter E, Teixeira A, Schaschl H, Harvey J, Rowan A, Jones A, Spain S, Clark S, Guenther T, Stewart A, Silver A, Tomlinson I. (2009). A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences of colorectal cancer risk. BMC Med Genet 10:54
• Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot IC, Glynne-Jones R, Northover JMA, Guenther T. (2009). Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only Hypoxia-inducible factor-1 is associated with prognosis. British J. Cancer, 100:1666-73.
• Robinson J, Lai C, Martin A, Nye E, Tomlinson I, Silver A. (2009). Oral rapamycin reduces tumour burden and vascularisation in Lkb1+/- mice. J Pathol, 31 March [Epub ahead of print].
• Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E, McCart A, Mandir N, Silver A, Goodlad R, Stamp G, Cockman M, East P, Spencer-Dene B, Poulsom R, Wright N, Tomlinson I. (2009). The Apc(1322T) mouse develops severe polyposis associated with sub-maximal nuclear beta-catenin expression. Gastroenterology Feb 25. [Epub ahead of print]
• Elahi E, Suraweera N, Volikos E, Haines J, Brown N, Davidson G, Churchman M, Ilyas M, Tomlinson I, Silver A. (2009). Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R ApcMin/+ mice. PLoS ONE. 4:e4388.
• Rasheed S, Harris AL, Tekkis PP, Turley H, Silver A, McDonald PJ, Talbot PJ, Glynne-Jones R, Northover JMA, Guenther T. (2009).Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer. Pathology Research and Practice. 205:1-9.
• Vickaryous N, Polanco-Echeverry G, Morrow S, Suraweera N, Thomas H, Tomlinson I, Silver A. (2008). Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome. British J. Cancer. 99:1726-8.
• Segditas S, Sieber O, Deheragoda M, East P, Rowan A, Jeffery R, Nye E, Clarke S, Spencer-Dene B, Stamp G, Poulsom R, Suraweera N, Silver A, Ilyas M, Tomlinson I. (2008). Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. Hum Mol Genet. 17:3864-75.
• Robinson J, Nye E, Stamp G, Silver A. (2008) Osteogenic tumours in Lkb1-deficient mice. Experimental and Molecular Pathology. 85:223-6.
• McCart AE, Vickaryous N, Silver A. (2008) Apc mice: models, modifiers and mutants. Pathology Research and Practice. 204:479-90.
• Sengupta N, Gill KA, MacFie T, C. Lai, Suraweera N, Mcdonald S, Silver A. (2008). Management of colorectal cancer: a role for genetics in prevention and treatment? Pathology Research and Practice 204:469-77.
• Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S, Penegar S, Chandler I, Gorman M, Wood W, Barclay E, Lubbe S, Martin L, Sellick G, Jaeger E, Hubner R, Wild R, Rowan A, Fielding S, Howarth K, Silver A, Atkin W, Muir K, Logan R, Kerr D, Johnstone E, Sieber O, Gray R, Thomas H, Peto J, Cazier J-P, Houlston R. (2007) A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nature Genet. 39:984-8
• Patel H, Polanco-Echeverry E, Segditsas S, Volikos E, McCart A, Lai C, Guenther T, Zaitoun A, Sieber O, Ilyas M, Northover J, Silver A. Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma. International Journal of Cancer 121:2668-2673, 2007
• Carvajal-Carmona L, Howarth K, Lockett M, Polanco-Echeverry G, Volikos E, Gorman M, Barclay E, Martin L, Jones A, Saunders B, Guenther T, Donaldson A, Paterson J, Frayling I, Novelli M, Phillips R, Thomas H, Silver A, Atkin W, Tomlinson I. (2007) Molecular classification and genetic pathways in hyperplastic polyposis syndrome. J Pathol. 212:378-85
• Suraweera N, Latchford A, Mccart A, Rogers P, Spain S, Sieber O, Phillips R, Tomlinson I, Silver A. (2007). Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in FAP patients. J Med Genet. 44:541-4.
• A Latchford, E Volikos, V Johnson, P Rogers, N Suraweera, I Tomlinson, R Phillips, Andrew Silver. (2007). APC mutations in FAP-associated desmoid tumours are non-random but not ?just right?. Hum Mol Genet 16:78-82.
• O Will, L Carvajal-Carmona* 1 , P Gorman, K. Howarth, A Jones, G Polanco-Echeverry, J-A ChinAleong, T Günther, A Silver, S Clark , I Tomlinson. (2006). Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. Gastroenterology in press
• Suraweera N, Robinson J, Volikos E, Gunther T, Talbot I, Tomlinson I, Silver A. (2006). Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines. International J. Cancer 119:1837-42.
• McCart A, Latchford A, Volikos E, Rowan A, Tomlinson I, Silver A. A novel exon duplication leading to a truncating germ-line mutation of the APC gene in a familial polyposis coli family. Familial Cancer 5:205-8.
• Volikos E, Robinson J, Aittomoki K, Mecklin J-P, Jorvinen, Westerman A, de Rooijj F, Vogel T, Moeslein G, Launonen V, Tomlinson I, Silver A, Aaltonen L. (2006). Lkb1 exonic and whole-gene deletions are a common cause of Peutz-Jeghers syndrome. J Med Genet 43:e18.
• Sieber O, Segditsas S, Knudsen A, Zhang J, Luz J, Rowan A, Spain S, Thirlwell C, Howarth K, Jaeger E, Robinson J, Volikos E, Silver A, Kelly G, Aretz S, Frayling I, Hutter P, Dunlop M, Guenther T, Neale K, Phillips R, Heinimann K, Tomlinson I. (2006). Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly, but depend on the site of the germline mutation. Gut 55:1440-1448.
• Patel H, Silver A, Northover J. (2005). Anal cancer in renal transplantation patients. Int. J. Colorectal Cancer. 16:1-5.
• Rowan A, Halford S, Gaasenbeek M, Kemp Z, Sieber O, Volikos E, Douglas E, Fiegler H, Carter N, Talbot I, Silver A, Tomlinson I. (2005). Analysis of somatic mutations, copy number and genomic instability suggests refined molecular pathways of colorectal carcinogenesis. Clinical Gastroenterology and hepatology 3:1115-23.
• Johnson J, Lipton LR, Cummings C, Eftekhar Sadat AT, Izatt L, Hodgson SV, Talbot IC, Thomas HJW, Silver ARJ, Tomlinson IPM. (2005). Analysis of somatic molecular changes, clinicopathological features, family history and germline mutations in colorectal families: evidence for efficient diagnosis of HNPCC and for distinct groups of non-HNPCC families. J Med Genet. 42:756-62.
• J Robinson, V Johnson, PA Rogers, RS Houlston, ER Maher, DT Bishop, DG Evans, HJW Thomas, IPM Tomlinson, ARJ Silver. (2005). Evidence for an association between compound heterozygosity for germ-line mutations in the haemochromatosis (HFE) gene and increased risk of colorectal cancer. Cancer Epidemiology Biomarkers and Prevention 14:1460-3.
• Suraweera N, Meijne E, Moody J, Carvajal-Carmona LG, Yoshida K, Pollard P, Fitzgibbon J, Riches A, van Laar T, Huiskamp R, Rowan A, Tomlinson, Silver A. (2005). Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia. Oncogene 24:3678-83 .
• Haines J, Johnson V, Pack K, Suraweera N, Slijepcevic P, Cabuy E, Coster M, Ilyas M, Wilding J, Sieber O, Bodmer W, Tomlinson I, Silver A. (2005). Genetic basis of variation in adenoma multiplicity in Apc Min/+ Mom1 S mice. Proc. Natl. Acad. Sci. USA. 102:2868-2873.
• Johnson V, Volikos E, Halford S, Eftekhar Sadat A, Popat S, Talbot I, Truninger K, Martin J, Jass J, Houlston R, Atkin W, Tomlinson I, and Silver A. (2005). Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in the hereditary non-polyposis colorectal cancer syndrome. Gut 54:264-267.
• Sieber OM, Howarth KM, Thirlwell C, Rowan A, Mandir N, Goodlad RA, Gilkar A, Spencer-Dene B, Stamp G, Johnson V, Silver A, Miller JH, Ilyas M, Tomlinson IPM. (2004) Myh deficiency enhances intestinal tumourigenesis in multiple intestinal neoplasia (Apc Min/+) mice. Cancer Res 64:8876-8881.
• Latchford A, Silver A and Phillips R. (2004). Familial adenomatous polyposis associated desmoid disease. CME J Gastroenterology, Hepatology & Nutrition 6:22-27.
• Suraweera N, Zampeli E, Rogers P, Atkin W, Forbes A, Harbord M, and Silver A. (2004). NCF1 (p47 phox ) and NCF1 pseudogenes are not associated with inflammatory bowel disease. Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 10:758-762
• Kemp Z, Thirlwell C, Sieber O, Silver A, and Tomlinson I. (2004). An update on the genetics of colorectal cancer. Hum Mol. Genet. 13:R177-185.
• Sturt N, Gallagher M, Bassett P, Philp C, Neale K, Tomlinson I, Silver A and Phillips R. (2004). Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis (FAP) independent of the germline APC mutation. Gut 53:1832-1836.
• Degg N, Weil M, Edwards A, Haines J, Coster M, Moody J, Ellender M, Cox R and Silver A (2003). Adenoma multiplicity in Irradiated ApcMin mice is modified by chromosome 16 segments from BALB/c Cancer Research 63:2361-2363.
• Finnon R, Moody J, Meijne E, Haines J, Clark D, Edwards A, Cox R and Silver A. (2002). A major breakpoint cluster domain in murine radiation-induced acute myeloid leukaemia. Mol. Carcinog. 34:64-71.
• Wilding J, Meijne E, Haines J, Moody J, Edwards A, Newbold R, Parris C, Cox R, and Silver A (2002). Functional evidence from microcell-mediated chromosome transfer of myeloid leukaemia supressor genes on human chromosomes 7 and 11. Genes, Chrom. & Cancer 34:390-397.
• Bouffler S, Silver A and Cox R . (2002) Mechanistic and genetic studies of radiation tumorigenesis in the mouse--implications for low dose risk estimation. J Radiol Prot. 22:11-16.
• Finnon P, Wong H-P, Silver A, Slijepcevic and Bouffler S (2001). Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line. Int. J. Rad Biol. 77:1151-1162.
• Meijne E, Huiskamp R, Haines J, Moody J, Finnon R, Wilding J, Spanjer S, Bouffler S, Edwards A, Cox R and Silver A. (2001). Analysis of loss of heterozygosity in lymphoma and leukaemia arising in F1 hybrid mice locates a common region of chromosome 4 loss. Genes, Chrom. & Cancer 31:373-381.
• Yu Y, Okayasu R, Weil M, Silver A, Cox R, McCarthy M, Zabriskie R, Long S and Ullrich R (2001). Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA PKcs) gene. Cancer Research 61:1820-1824.
• O'Hare M, Bond J, Clarke C, Takeuchi Y, Atherton A, Berry C, Moody J, Silver A, Davies D, Alsop A, Neville A and Jat P (2001). Conditional immortalization of freshly isolated human mammary fibroblasts and endothelial cells. Proc. Natl. Acad. Sci. USA, 98: 646-651.