Home| Professor of Virology |
Contact details:
| Tel: | +44 20 7882 7966 |
| Fax: | +44 20 7882 6990 |
| Email: | j.s.oxford@retroscreen.com |
| Address: | Retroscreen Virology, |
Biograpy:
John Oxford is Professor of Virology at Barts and The London School of Medicine and Dentistry. He has co-authored two standard texts: 'Influenza, the Viruses and the Disease with Sir Charles Stuart-Harris and G.C. Schild and most recently 'Human Virology, a Text for Students of Medicine, Dentistry and Microbiology' published by Oxford University Press. Professor Oxford has also published 250 scientific papers.
Research Activity:
His research interest is the pathogenicity of influenza, in particular the 1918 Spanish Influenza strain, which he combines with conducting clinical trials using new influenza vaccines and antiviral drugs. This research has been featured on Science TV programmes recently in the UK , USA , Germany and Holland . He is Scientific Director of the college research virology company called Retroscreen Virology Ltd (www.retroscreen.com ).
Publications:
• Oxford, J.S., Manuguerra, C., Kistner, O., Linde, A., Kunze, M., Lange, W., Schweiger, b., Spala, G., Rebelo de Andrade, H., Perez Brena, P.R. Beytout, J., Brydak, L., Caraffa de Stefano, D., Hungnes, O., Kynel, J., Montomoli, E., Gil de Miguel, A., Vranckx, R. Osterhaus, A. (2005). A new European perspective of influenza pandemic planning with a particular focus on the role of mammalian cell culture vaccines. Vaccine , 23 : 5440-9.
• Oxford , J.S., Lambkin, R., Gibb, I. , Balasingam, S., Chan, C., Catchpole, A. (2005). A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV . Antiviral Chem Chemother ., 16 : 129-34.
• Oxford , J.S. (2005). Preparing for the first pandemic of the 21 st century. Lancet Infect Dis ., 5 : 129-31.
• Oxford, J.S., Gelder, C., Lambkin, R. (2005). Would you volunteer to be quarantined and infected with influenza virus? Expert Rev Anti Infect Ther ., 3 : 1-2.
• Oxford , J.S., Balasingam, S., Chan, C., Catchpole, A., Lambkin, R. (2005). New antiviral drugs, vaccines and classic public health interventions against SARS coronavirus. Antivir Chem Chemother ., 16 : 13-21.
• Oxford , J.S., Lambkin, R., Sefton, A., Daniels, R., Elliot, A., Brown, R., Gill, D. (2005). A hypothesis: the conjunction of soldiers, gas, pigs, geese and horses in northern France during the Great War provided the conditions for the emergence of the "Spanish" influenza pandemic of 1918-1919. Vaccine , 23 : 940-5.
• Oxford, J.S., Mann, A., Lambkin, R. (2003). A designer drug against influenza: the NA inhibitor oseltamivir (Tamiflu). Expert Rev Anti Infect Ther ., 1 : 337-42.
• Lambkin, R., Oxford , J.S., Bossuyt, S., Mann, A., Metcalfe, I.C., Herzog, C., Viret, J.F., Gluck, R. (2004). Strong local and systemic protective immunity in the ferret model by an intranasal virosome-formulated influenza subunit vaccine. Vaccine , 22 : 4390-6.
• Dourmashkin, R.R., Oxford , J.S. Bountiff, L. (2004). Immunogold electron microscopy recognizes prion protein-associated particles prepared from scrapie-infected mouse brain. J Neuropathol Exp Neurol , 63 : 31-42.
• Reid, A.H., Janczewski, T.A., Lourens, R.M., Elliot, A.J., Daniels, R.S., Berry , C.L., Oxford , J.S., Taubenberger, J.K. (2003). 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants. Emerg Infect Dis ., 9 : 1249-53.
• Oxford , J.S., Bossuyt, S., Lambkin, R. (2003). A new infectious disease challenge: Urbani severe acute respiratory syndrome (SARS) associated coronavirus. Immunology , 109 : 326-8.
• Oxford , J.S., Al-Jabri, A.A., Lambkin, R., Palache, A.M., Fleming, D.M. (2003). Non-responders to egg grown influenza vaccine seroconvert after booster immunization with MDCK cell grown vaccine. Vaccine , 21 : 2743-6.
• Lo, K.C., Geddes, J.F., Daniels, R.S., Oxford , J.S. (2003). Lack of detection of influenza genes in archived formalin-fixed, paraffin wax-embedded brain samples of encephalitis lethargica patients from 1916 to 1920. Virchows Arch ., 442 : 591-6.
• Oxford , J.S., Bossuyt, S., Balasingam, S., Mann, A., Novelli, P., Lambkin, R. (2003). Treatment of epidemic and pandemic influenza with neuraminidase and M2 proton channel inhibitors. Clin Microbiol Infect ., 9 : 1-14.
• Greaves, K., Oxford , J.S., Price, C.P., Clarke, G.H., Crake, T. (2003). The prevalence of mycocarditis and skeletal muscle injury during acute viral infection in adults: measurement of cardiac troponins I and T in 152 patients with acute influenza infection. Arch Intern Med ., 163 : 165-8.
• Oxford , J.S., Novelli, P., Sefton, A., Lambkin, R. (2002). New Millennium antivirals against pandemic and epidemic influenza: the neuraminidase inhibitors. Antivir Chem Chemother., 13 : 205-17.
• Ives, J.A., Carr, J.A., Mendel, D.B., Tai, C.Y., Lambkin, R., Kelly, L., Oxford , J.S., Hayden, F.G., Roberts, N.A. (2002). The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo. Antiviral Res ., 55 : 307-17.
• Oxford , J.S. (2002). Influenza A: a threatening virus with two faces. Biologist ( London ) , 49 : 63-7.
• Oxford , J.S., Sefton, A., Jackson , R., Innes, W., Daniels, R.S. Johnson, N.P. (2002). World War I may have allowed the emergence of "Spanish" influenza. Lancet , 2 : 111-4.
• Oxford , J.S. (2001). The so-called Great Spanish Influenza Pandemic of 1918 may have originated in France 1916. Philos Trans R Soc Lond B Biol Sci ., 356 : 1857-9.
• Welliver, R., Monto, A.S., Carewicz, O., Schatteman, E., Hassman, M., Hedrick, J., Jackson, H.C., Huson, L., Ward, P., Oxford , J.S. (2001). Effectiveness of oseltamivir in preventing influenza in household contacts: a randomised controlled trial. JAMA , 285 : 748-54.
