Home| Professor of Immunology |
| Dean for Research, Barts and The London School of Medicine and Dentistry |
Publications since 2001
• Monteleone G, Pender SLF, Alstead E, Wathen NC, Hauer AC, Lionetti P, McKenzie C, MacDonald TT 2001 Role of interferon- a in promoting T helper cell type 1 responses in the small intestine in coeliac disease. Gut 48:425-9..116.
• Salmela MT, Pender SLF, Reunala T, MacDonald TT and Saarialho-Kere U 2001 Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. Gut 48:496-502.
• Veitch AM, Kelly P, Zulu I, MacDonald TT, Farthing MJ 2001 Lack of evidence for small intestinal mucosal T-cell activation as a pathogenic mechanism in African HIV-associated enteropathy. Dig Dis Sci 46:1133-38.
• Goncalves NS, Ghaem-Maghami M, Monteleone G, Frankel G , Dougan G, Simmons CA, MacDonald TT 2001. A critical role for TNF- a in controlling lumenal pathogenic bacterial numbers and immunopathology in infectious colitis. Infection and Immunity . 69:6651-9
• Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer H, MacDonald TT 2001 Blocking Smad7 restores TGF b 1 signalling in chronic inflammatory bowel disease. J Clin Invest 108:601-608 ( with accompanying commentary, 108:523-526)
• Salvati VM, Bajaj-Elliott M, Poulsom R, Mazzarella M, Lundin KEA, Nilsen EM, Troncone R, and MacDonald TT 2001 Keratinocyte growth factor and celiac disease. Gut 49:176-81
• Monteleone G, Pender SLF, Wathen NC and MacDonald. TT 2001 Interferon-??drives T cell-mediated immunopathology in the intestine. Eur J Immunol 31:2247-55.
• Shaida A, Kenyon G, Devalia J, Davies RJ, MacDonald TT, Pender SLF 2001. Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis. J Allergy Clin Immunol 108:791-6
• Jones CA, Vance GA, Power LL, Pender SL, MacDonald TT, Warner JO 2001 Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming. J Allergy Clin Immunol 108:235-41.
• Salvati VM, MacDonald TT, Bajaj-Elliott M,Borrelli M, StaianoA, Auricchio S, Troncone, R Monteleone G 2002 Interleukin-18 and associated markers of T helper cell type 1 activity in celiac disease. Gut 50:86-90.
• Simmons CP, Goncalves NS, Ghaem-Maghami M, Bajaj-Elliott M, Clare S, Frankel G, Dougan G, MacDonald TT 2002 Impaired resistance and enhanced pathology during infection with a non-invasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN- g . Journal of Immunology 168:1804-12.
• Salmela MT, MacDonald TT, Black D, Miles B, Zhuma T, Saarialho-Kere U and Pender SLF. 2002. Upregulation of matrix metalloproteinase in a model of T cell-mediated tissue injury in the gut - analysis by gene array and in situ hybridisation. Gut 2002 51:540-7.
• Taylor L, Bachler M, Duncan I, Keen S, Fallon R, Mair C, MacDonald TT, Schwarz H 2002 In vitro and in vivo activities of OX40 (CD134)-IgG fusion protein isoforms with different levels of immune-effector functions. J Leukocyte Biology 2002 72:522-9.
• Mazzarella G, MacDonald TT, Salvati VM, Mulligan P, Pasquale L, Stefanile R, Lionetti P Troncone R, Monteleone G 2003. Activation of signal transducer and activator of transcription 1 in celiac disease. Am J Pathol 162:1845-55
• Salvati VM, MacDonald TT, Mazzarella G,Lionetti P, Troncone R, Monteleone G 2003 Enhanced expression of interferon regulatory factor-1 in celiac disease mucosa. Ped Res 54:312-318.
• Hauer AC, Riederer M, Griessl A, Rosegger H and MacDonald TT 2003 Cytokine production by cord blood mononuclear cells stimulated with cows milk proteins in vitro: IL-4 and TGF b secreting cells detected in the CD45R0 T cell population in children of atopic mothers. Clin Exp Allergy 33:615-23 .
• Monteleone G, Holloway J, Salvati VM, Pender SLF, Fairclough PD, Croft N, MacDonald TT 2003 Activated STAT4 and a functional role for IL-12 in human Peyer's patches. J Immunol 170:300-7.
• Pender SLF, Braegger C, Günther U, Monteleone G, Meuli M, Schuppan D and MacDonald TT 2003 Matrix metalloproteinases in necrotising enterocolitis. Ped Res 54:160-164.
• Goncalves NS, Hale C, Dougan G, Frankel G, MacDonald TT 2003 Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences. Infection and Imunity 71:2960-5.
• Simmons CP, Clare S, Ghaem-Maghami M, Uren TK, Rankin J, Huett A, Goldin R, Lewis DJ, MacDonald TT, Strugnell RA, Frankel G, Dougan G 2003 Central role for B lymphocytes and CD4+ T cells in immunity to infection by the attaching and effacing pathogen Citrobacter r odentium . Infection and Immunity 71:5077-86.
• Monteleone G, Mann J, Monteleone I, Vavassori P, Bremner R, Fantini M, Del Vecchio Blanco G, Tersigni R, Alessandroni L, Mann DA, Pallone F, MacDonald TT 2004 A failure of TGF b 1 negative regulation maintains sustained NK-KB activation in gut inflammation. J Biol Chem 279(6):3925-32.
• Monteleone G, Del Vecchio Banco G, Palmieri G, Monteleone I, Vavassori P, Colantoni A, Battista S, Guisto Spagnoli L, Romano M, MacDonald TT, Pallone F 2004 Defective TGF b 1 signaling associates with high Smad7 in the gastric mucosa of patients with H. pylori infection. Gastroenterology 126(3):674-82.
• Monteleone I, Monteleone G, Del Vecchio Blanco G, Cucchiara S, MacDonald TT, Pallone F. 2004 Regulation of the T helper cell type 1 transcription factor T-bet in celiac disease mucosa . Gut 53:1090-1095.
• Veitch AM, Higgins LM, Bajaj-Elliot M, Farthing MJG, MacDonald TT 2003 Impaired rejection and mucosal injury of small intestinal allografts lacking the interferon- g receptor. Int J Exp Path 84:107-113.
• Pender SLF, Croucher PJP, Mascheretti S, Prothero JD, Fisher SA, MacDonald TT, Schreiber S and Ye S. 2004 Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease. J Med Genetics e112.
• Mimura T, Bateman AC, Lee RL, Johnson PA, McDonald PJ, Talbot IC, Kamm MA, MacDonald TT, Pender SL. 2004 Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease. Dis Colon Rectum. 47(3):371-8.
• Li CKF, Pender SLF, Chance V, Holloway JA, Huett A, Gonçalves N, Mudgett J, Dougan G, Frankel G, and MacDonald TT 2004 Impaired immunity to intestinal bacterial infection in stromelysin-1 (MMP-3) deficient mice. J Immunol 173(8):5171-9.
• Salmela MT , Pender SL, Karjalainen-Linsberg ML, Puolakkainen P, MacDonald TT, Saarialho-Kere U 2004 Collagenase 1 ( MMP-3), matrilysin-1 (MMP-7) and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing. Scand J Gastroenterol 39:1095-1104.
• Monteleone G, Monteleone I, Fina D, Vavassori P, Del Vecchio Blanco G, Tersigni R, Alessandroni L, Biancone L, MacDonald TT, Pallone F 2005 IL-21 enhances T helper cell type I signalling and interferon- g production in Crohn's disease. Gastroenterology 128(3):687-94.
• Gunther U, Holloway JA, Gordon JG, Knight A, Chance V, Hanley NA, Wilson DI, French R, Spencer J, Steer H, Anderson G, MacDonald TT. 2005 CD3-7+ cells are T cell precursors in human gut early in life. J Immunol 174:5414-22.
• Prasad S, Mongrino R, Kaukinen K, Hayes KL, Powell RM, MacDonald TT, Collins JE. 2005 Inflammatory processes have different effects on claudins 2,3 and 4 in colonic epithelial cells. Lab Invest 85 :1139-62
• Kruidenier L, MacDonald TT, Collins JE, Pender SLF, Sanderson IR 2006 Myofibroblast derived MMP's activate a potent neutrophil chemoattractant secreted by intestinal epithelial cells. Gastroenterology 130 :127-36
• Pender SLF, Chance V, Whiting CV, Buckley M, Edwards M, Pettipher R, MacDonald TT (2005). Systemic administration of the chemokine MIP-1 a exacerbates inflammatory bowel disease in a mouse model. Gut 54:1114-20.
• Brittan M, Chance V, Elia G, Poulsom R, Alison MR, MacDonald TT, Wright NA 2005 A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts.Gastroenterology. 128:1984-95. ( NAW and TTM, joint principal authors).
• Monteleone G, Del Vecchio Blanco G, Monteleone I, Fina D, Caruso R, Gioia V, Ballerini S, Federici G, Bernardini S, Pallone F, MacDonald TT 2005 . Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease. Gastroenterology 129:1420-9
• Boirivant M, Pallone F, Di Giacinto C, Fina D, Monteleone I, Marinaro M, Caruso R, Colantoni A, Palmieri G, Sanchez M, Strober W, MacDonald TT, Monteleone G. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis.Gastroenterology. 2006; 131 ( 6 ): 1786-98 .
• Caruso R, Pallone F, Fina D, Gioia V, Peluso I, Caprioli F, Stolfi C, Perfetti A, Spagnoli LG, Palmieri G, Macdonald TT, Monteleone G. Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation. Am J Pathol. 2006 Jul; 169 ( 1 ): 268-78 .
• Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, Fantini MC, Caprioli F, Tersigni R, Alessandroni L, MacDonald TT, Pallone F. Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut. 2006 Dec; 55 (12): 1774-80 .
• Peluso I, Fantini MC, Fina D, Caruso R, Boirivant M, MacDonald TT, Pallone F, Monteleone G. IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes. J Immunol. 2007; 178 ( 2 ): 732-9
• Caruso R, Fina D, Peluso I, Stolfi C, Fantini MC, Gioia V, Caprioli F, Del Vecchio Blanco G, Paoluzi OA, Macdonald TT, Pallone F, Monteleone G. A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology. 2007 132 ( 1 ): 166-75
• Lottaz D, Buri C, Monteleone G, Rösmann S, Macdonald TT, Sanderson IR, Sterchi EE. Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac diseases. Biol Chem. 2007 388 ( 3 ): 337-41 .
• Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F, Andrei F, Stolfi C, Romano M, Ricci V, MacDonald TT, Pallone F, Monteleone G. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J Immunol. 2007 178 ( 9 ): 5957-65 .
• Di Sabatino A, Pender SL, Jackson CL, Prothero JD, Gordon JN, Picariello L, Rovedatti L, Docena G, Monteleone G, Rampton DS, Tonelli F, Corazza GR, MacDonald TT . Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies. Gastroenterology. 2007 133 ( 1 ): 137-49 .
• Fantini MC, Rizzo A, Fina D, Caruso R, Becker C, Neurath MF, Macdonald TT, Pallone F, Monteleone G . IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells. Eur J Immunol. 2007 37 ( 11 ): 3155-63 .
• Di Sabatino A, Pickard KM, Gordon JN, Salvati V, Mazzarella G, Beattie RM, Vossenkaemper A, Rovedatti L, Leakey NA, Croft NM, Troncone R, Corazza GR, Stagg AJ, Monteleone G, MacDonald TT. Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease. Gastroenterology.2007 133 ( 4 ): 1175-87 .
• Fina D, Sarra M, Caruso R, Del Vecchio Blanco G, Pallone F, Macdonald TT, Monteleone G. Interleukin-21 contributes to the mucosal T helper cell type 1 response in celiac disease. Gut. 2007 Oct
• Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SL, Goggin PM, Macdonald TT . Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease. Inflamm Bowel Dis.2007 14 ( 2 ): 195-203
• Sengupta N, Macdonald TT . The role of matrix metalloproteinases in stromal/epithelial interactions in the gut. Physiology. 2007 22 : 401-9 .
• Di Sabatino A, Pickard KM, Rampton D, Kruidenier L, Rovedatti L, Leakey NA,Corazza GR, Monteleone G, Macdonald TT. Blockade of transforming growth factor-{beta} up-regulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa. Gut. 2008 (in press)
Reviews, book chapters etc
• Monteleone G and .MacDonald TT 2001 T cell response to oral antigens. Mod Aspects of Immunobiol 2: 28-31.
• Monteleone G, Pender SLF, Alstead E, Hauer C A, Lionetti P, MacDonald TT Onset of celiac disease during interferon-a therapy. Review Series Oncology 2001; 4: 18-19.
• MacDonald TT and Monteleone G 2002 Bacteria and the regulation of T cell function in the gut. In Gut Ecology, edited by Ailsa Hart, Andrew Stagg, Hans Graffner, Hans Glise, Per Falk and Michael Kamm, Martin Dunitz Ltd, London pp57-65.
• MacDonald TT 2002 Summary and observations of the session on "The Host Response to the Normal Intestinal Flora" in Gut Ecology, edited by Ailsa Hart, Andrew Stagg, Hans Graffner, Hans Glise, Per Falk and Michael Kamm, Martin Dunitz Ltd, London pp66-69.
• MacDonald TT 2002 Targets for Inflammatory Bowel Disease-biological therapy. In Research and Clinical Forums 24:61-66.
• Monteleone G, Pender SLF, Alstead E, Hauer CA, Lionetti P, MacDonald TT 2002 Role of interferon- a in celiac disease. Review Series Pediatrics 2:18-19.
• MacDonald TT 2002 The biochemical basis of immune enteropathy. J Ped Gastro Nutr 34:S27-30.
• MacDonald TT 2002 Suppressor T cells, rebranded as regulatory T cells, emerge from the wilderness bearing surface markers. Gut 51:311-2.
• MacDonald TT 2002 Mucosal lymphoid tissue. in Food Allergy and Intolerance, edited by SJ Challacombe and J Brostoff, Bailliere Tindall, London pp3-13.
• MacDonald, Frankel G, Dougan G, Simmons C 2003 Host defences to Citrobacter rodentium . International Journal of Medical Microbiology 293:87-93.
• MacDonald TT, Pender SLF 2004 Mechanisms of Tissue Injury, in Kirsner's Inflammatory Bowel Disease, edited by R Balfour Sartor and William Sandborn, WB Saunders, London pp 163-178.
• MacDonald TT 2003 Mucosal Immunology. Parasite Immunology 25:235-46.
• Pickard K, Bremner R, Gordon J and MacDonald TT 2004 Host responses to the normal gut microflora: immune responses. Best Pract Res Clin Gastroenterol. 18(2):271-85.
• Monteleone G and MacDonald TT 2004 The role of T cells in the intestinal mucosa, in Oral Tolerance: the response of the intestinal mucosa to dietary antigens, edited by Olivier Morteau, Kluwer Academic/Plenum Publishers pp 52-63.
• MacDonald TT 2004 A mouse model of intestinal fibrosis. Editorial-Gastroenterology 125(6):1889-92.
• MacDonald TT, Miller RE 2005 Phylogeny of the mucosa-associated lymphoid tissues. In Mucosal Immunology 3 rd edition, edited by J Mestecky, ME Lamm, W Strober, J Bienenstock, JR McGhee, L Mayer, Academic Press, San Diego (in press).
• MacDonald TT, Monteleone G 2005 Human gut-associated lymphoid tissues. In Mucosal Immunology 3 rd edition, edited by J Mestecky, ME Lamm, W Strober, J Bienenstock, JR McGhee, L Mayer, Academic Press, San Diego pp407-413
• Gordon JN, MacDonald TT 2003 Biological therapy in Crohn's Disease. Hospital Medicine 64(12):708-12.
• Monteleone G, Pallone F, MacDonald TT 2004 Smad7 in TGF b -mediated negative regulation of gut inflammation. Trends in Immunology 25:513-7.
• MacDonald TT, Monteleone G 2004 The Smad signalling pathway in Crohn's disease and ulcerative colitis. In Mechanisms of Intestinal Inflammation-Implications for therapeutic intervention in IBD. Edited R Duchmann et al, Falk Symposium No 133 pp133-136.
• Pender SL, MacDonald TT 2004 Matrix metalloproteinases and the gut-new roles for old enzymes. Curr Opin Pharmacol 4:546-50.
• MacDonald TT, DiSabatino A, Gordon JN 2005 Immunopathogenesis of Crohn's disease. JPEN J Parenter Enteral Nutr. 29(4 Suppl):S118-25.
• MacDonald TT, Gordon JN 2005 Bacterial Regulation of Intestinal Immune Responses. Gastro Clinics North America 34(3):401-12.
• Gordon JN, DiSabatino A, MacDonald TT 2005 The pathophysiological rationale for biological therapy in inflammatory bowel disease. Curr Opin Gastroenterology 21:431-7.
• MacDonald TT, Monteleone G 2005 Immunity, Inflammation and Allergy in the Gut. Science 307:1920-25.
• MacDonald TT, Di Sabatino A, Gordon JN 2005 Immunopathogenesis of Crohn's disease. JPEN J Parenter Enteral Nutr. 29(4 Suppl):S118-24.
• Gordon JN, MacDonald TT 2005 Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn's disease. Gut. 54(9):1213-5.
• MacDonald TT 2006 Decoy receptor springs to life and eases fibrosis. Nature Medicine News and Views12(1):13-4.
• MacDonald TT and Monteleone G 2005 Role of the immune system in the pathogenesis of IBD. In " Immune Mechanisms in IBD" edited by Markus Neurath and Richard Blumberg, Adv Exp Med Biol. 2006;579:98-107.
• MacDonald TT, Di Sabatino A 2006 The exposure of infants to Lactobacillus thamnosus GG in Finland . J Ped Gastro Nutr 32:476-8.
• MacDonald TT 2006 the significance of ileocolonic lymphoid hyperplasia in children with autistic spectrum disorder, Eur J Gastro Hepatol 18:569-71.
• Mundy R, MacDonald TT, Dougan G, Frankel G, Wiles S 2006 Citrobacter rodentium in mice and man. Cell Micro 7:1697-706.