Home| Professor of Viral Pathology |
Publications since 2001
• K.M. Cheney, Á. McKnight. Interferon-Alpha Mediates Restriction of Human Immunodeficiency Virus Type-1 Replication in Primary Human Macrophages at an Early Post-Entry Stage of Replication. PLoS One. 2010 5(10): e13521. doi: 10.1371
• Nidia MM Oliveira, Roochi Trikha and Áine McKnight. A novel envelope mediated post entry restriction of Murine Leukaemia Virus in human cells is Ref1/TRIM5alpha independent. Retrovirology 2010, 7:81doi:10.1186/1742-4690-7-81
• Hanna Dreja, Eithne M. O'Sullivan, Corinna Pade, Kelli M. Greene, Hongmei Gao, Keith Aubin, James Hand, Are Isaksen, Carl D'Souza, Werner Leber, David Montefiori, Michael S. Seaman, Jane Anderson, Chloe Orkin and Áine McKnight. Neutralisation activity in a geographically diverse East London cohort of HIV-1 infected patients: Clade C infection results in a stronger and broader humoral immune response than clade B infection. J General Virology 2010: 91:2794
• Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies. Kathryn H Richards, Marlén MI Aasa-Chapman, Áine McKnight, and Paul R Clapham. Retrovirology. 2010; 7: 48.
• Anti-infective activity of apolipoprotein domain derived peptides in vitro: identification of novel antimicrobial peptides related to apolipoprotein B with anti-HIV activity. Bridie A Kelly, Ian Harrison, Áine McKnight, and Curtis B Dobson. BMC Immunol. 2010; 11: 13
• Willie W. L. Koh, Anna Forsman, Stephane Hue, Gisela J. van der Velden, David L. Yirrell, Áine McKnight, Robin A. Weiss and Marlen M. I. Aasa-Chapman. Novel subtype C HIV-1 envelopes cloned directly from plasma: Coreceptor usage and neutralisation phenotypes. J General Virology 2010; 91:2374
• Davide Corti, Hans Landedijk, Andreas Hinz, Mike S. Seaman, Fabrizia Vanzetta, Blanca Fernandez, Chiara Silacci, David Jarrossay, Sunita Balla-Jhagjhoorsingh, Hanna Dreja, Eithne O’Sullivan, Corinna Pade, Chloe Orkin, Betty Willems, Debora Pinna, Simon A. Jeffs, John R. Mascola, David C. Montefiori, Wouter Janssens, Winfried Weissenhorn, Áine McKnight, Federica Sallusto, Robin A. Weiss and Antonio Lanzavecchia. Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals PLoS One 2010 5(1)
• K.M. Cheney, Á. McKnight. HIV-2 Tropism and Disease. Lentiviruses and Macrophages: Molecular and Cellular Interactions. M. Desport, Caister Academic Press. 2010: p165-180
• Áine McKnight and Daniel J Pennington. HIV Vaccine Approaches. Encyclopaedia of life Sciences (ELS), John Wiley & Sons, Ltd (June 2009)
• Anna Forsman, Els Beirnaert, Marlén Aasa-Chapman, Bart Hoorelbeke Andrea Gorlani, Karolin Hijazi, Willie Koh, Vanessa Tack, Amos Zhao, Agnieszka Szynol, David Lutje Hulsik, Charles Kelly, Áine McKnight, Theo Verrips, Hans de Haard and Robin Weiss. Llama antibody fragments with cross-subtype HIV-1 neutralising properties and high affinity for HIV-1gp120. Journal of Virology 2008;82(24):12069-81
• Marlén M. I. Aasa-Chapman and Áine McKnight “HIV vaccines a long road ahead” Ibscientific Journal of Science 2007; Vol 2(3), pp 41-43
• Bridie A. Kelly, Stuart J. Neil, Áine McKnight, Joana M. Santos, Photini Sinnis, Edward R. Jack, David A. Middleton and Curtis B. Dobson.Apolipoprotein E-derived anti-microbial peptide analogues with altered membrane affinity and increased potency and breadth of activity. FEBS Journal 2007 (17), 4511–4525.
• Áine McKnight and Marlén M.I. Aasa-Chapman. Clade specific neutralising vaccines for HIV: An appropriate target? Current HIV Research, Volume 5, Number 6, November 2007, pp. 554-560(7)
• Marlén M I Aasa-Chapman, Craig R Seymour, Ian Williams, and Áine McKnight . Novel Envelope Determinants for CCR3 use by Human Immunodeficiency Virus. J Virol 2006 Nov;80(21):10884-9
• Marlén M.I. Aasa-Chapman, Keith Aubin, Ian Williams and Áine McKnight , Primary CCR5 only using HIV-1 isolates does not accurately represent the in vivo replicating quasi-species 2006 Virology Aug 1;351(2):489-96.
• Marchant, D., S.J.D. Neil, Á. McKnight , Human immunodeficiency virus types 1 and 2 have different replication kinetics in human primary macrophage culture. 2006; J Gen Virol. 87: 411-418
• Neil SJ, Aasa-Chapman MM, Clapham PR, Nibbs RJ, McKnight A , Weiss RA. The Promiscuous CC Chemokine Receptor D6 Is a Functional Coreceptor for Primary Isolates of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 on Astrocytes. J Virol. Aug;79(15):9618-24.
• Marchant D, Neil SJ, Aubin K, Schmitz C, McKnight Á. An Envelope-Determined, pH-Independent Endocytic Route of Viral Entry Determines the Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 to Lv2 Restriction. 2005 J Virol. 79 9410-8.
• Neil SJ, McKnight Á, Gustafsson K, Weiss RA. HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivation. Blood. ;105:4693-9.
• Aasa-Chapman MM, Holuigue S, Aubin K, Wong M, Jones NA, Cornforth D, Pellegrino P, Newton P, Williams I, Borrow P, McKnight Á. 2005 Detection of antibody-dependent complement-mediated inactivation of both autologous and heterologous virus in primary human immunodeficiency virus type 1 infection. J Virol. 79:2823-30 .
• Aasa-Chapman, M.M.I., A. Hayman, P. Newton, D. Cornforth, I. Williams, P. Balfe, Á. McKnight , 2003 Development of the antibody response in acute HIV-1 infection. AIDS 2004:18371-8
• Schmitz, C., D. Marchant, S. Reuter, K. Aubin, M.T. Dittmar, Á. McKnight, 2004, Lv2, A Novel Post Entry Restriction is mediated by both Capsid and Envelope. J.Virol 78:2006-16
• Thomas, E.R., C. Shotton, R.A. Weiss, P.R. Clapham, Á. McKnight , 2003 CD4-dependent and CD4-independent HIV-2: consequences for neutralization. AIDS. 17: 291-300.
• Willey S, Roulet V, Reeves JD, Kergadallan ML, Thomas E , McKnight A, Jegou B, Dejucq-Rainsford N. 2003 Human Leydig cells are productively infected by some HIV-2 and SIV strains but not by HIV-1 AIDS 17:183-188.
• Willey, S.J., J.D. Reeves, R. Hudson, K. Miyake, N. Dejucq, D. Schols, E. De Clercq, J. Bell, Á. McKnight , P.R. Clapham, 2003 Identification of a subset of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains able to exploit an alternative coreceptor on untransformed human brain and lymphoid cells . J Virol. 77: 6138-52.
• Morner A, Thomas JA, Bjorling E, Munson PJ, Lucas SB, McKnight Á. 2003 Productive HIV-2 infection in the brain is restricted to macrophages/microglia.
AIDS . 17(10):1451-1455.
• Áine McKnight and Robin Weiss. 2003 Blocking the Docking of HIV Proc Natl Acad Sci U S A, 19:10581-2
• Clapham, P.R., Á. McKnight , 2002 Cell surface receptors, virus entry and tropism of primate lentiviruses. J Gen Virol. 83: 1809-29.
• McKnight , Á , D.J. Griffiths, M. Dittmar, P. Clapham, E. Thomas, 2001 Characterization of a late entry event in the replication cycle of human immunodeficiency virus type 2. J Virol . 75: 6914-22.
• Clapham, P.R., Á. McKnight , 2001 HIV-1 receptors and cell tropism. Br Med Bull . 58: 43-59.