Home| Professor of Trauma Sciences |
Contact details:
| Tel: | +44 20 7377 7695 |
| Fax: | +44 20 7377 7044 |
| Email: | karim.brohi@bartsandthelondon.nhs.uk |
| Address: | Centre for Neuroscience and Trauma, |
Biography
Karim Brohi is Professor of Trauma Sciences at Queen Mary and Consultant Trauma & Vascular Surgeon at Barts and the London NHS Trust. He is also Specialty Tutor for Trauma & Emergency Surgery at the Royal College of Surgeons of England .
Karim did his undergraduate medical training at University College London, where he also gained a BSc in Computer Science. He is a Fellow of the Royal College of Surgeons of England and a Fellow of the Royal College of Anaesthetists of Great Britain & Ireland . His surgical training was in London , Oxford and Cape Town and did his fellowship training at the University of California San Francisco .
Research Activity
Karim Brohi is the lead for research for the Trauma Clinical Academic Unit at Barts and the London NHS Trust. Research within the Trauma Group covers the breadth of the trauma sciences, from injury prevention and public health, the effects of trauma and the body's responses to injury and through all stages of management through to rehabilitation. The trauma group is developing laboratory, translational and clinical programmes in several research streams, and collaborates widely with other groups within the medical school, the university and our national and international partners.
A strong focus of our research has been the identification and characterisation of Acute Traumatic Coagulopathy, and the development of experimental models to explore new diagnostic tools and therapeutic interventions. We have received £2m funding from the National Institute of Health Research to continue our research in the field of trauma coagulopathy and massive transfusion in conjunction with the National Blood Service. We also have active programmes in public health, trauma imaging, emergency preparedness, operational research and biomarkers of traumatic injury. We have strong links with industry and are a world-leading institution in recruitment for trauma multicentre trials.
We are also developing a systems biology model to haemostasis with partners in the departments of Computer Science, Mathematics and the Genome Centre of the William Harvey Institute, as well as international collaborators at the University of California San Francisco and UC Berkeley.
Key Publications
• Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. Journal of Trauma. 2008;64:1211-7
• Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND, Pittet JF. Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma? Annals of Surgery. 2008;247:320-6
• Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early Coagulopathy after Traumatic Brain Injury: Role of Hypoperfusion and the Protein C Pathway. Journal of Trauma. 2007;63:1254-61
• Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007 Dec;13(6):680-5.
• Bent CL, Matson MB, Sobeh M, Renfrew I, Uppal R, Walsh M, Brohi K, Kyriakides C. Endovascular management of acute blunt traumatic thoracic aortic injury: A single center experience. J Vasc Surg. 2007;46:920-7.
• Brohi K, Ganter MT, Cohen MJ, Shaffer LA, Walsh MC, Stahl GL, Pittet JF. Role of the alternative pathway in the early complement activation following major trauma. Shock 2007 Jul;28(1):29-34
• Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: Initiated by hypoperfusion. Modulated through the protein C pathway? Annals of Surgery 2007 May;245(5):812-8
• Aylwin C, Konig T, Brennan N, Davies G, Walsh M, Brohi K. Reducing critical mortality in urban mass casualty incidents: triage, surge and resource utilization analysis of the London bombings of 7th July 2005. Lancet 2006; 368:2219-25
• Brohi K, Healy M, Fotheringham T, Chan O, Aylwin C, Whitley S, Walsh M. Helical CT for the evaluation of the cervical spine in the unconscious, intubated trauma patient. Journal of Trauma. 2005 May;58(5):897-901
• K Brohi, J Singh, M Heron, T Coats. Acute Traumatic Coagulopathy. Journal of Trauma 2003;54:1127-1130
