Home| Professor of Neurology |
Lead, Centre for Neuroscience and Trauma |
Publications since 2001
• Chamoun V, Zeman A, Blennow K, Fredman P, Wallin A, Keir G, Giovannoni G , Thompson EJ. Haptoglobins as markers of blood-CSF barrier dysfunction: the findings in normal CSF. J Neurol Sci. 2001;182:117-21.
• Palmer HE, Giovannoni G , Stanford MR, Wallace GR, Graham EM. Urinary neopterin in idiopathic retinal vasculitis. Br J Ophthalmol 2001;85:30-3.
• Giovannoni G , Thompson AJ, Miller DH, Thompson EJ. Fatigue is not associated with raised inflammatory markers in multiple sclerosis. Neurology 2001; 57:676-81.
• Giovannoni G , Miller DH, Losseff NA, Sailer M, Lewellyn-Smith N, Thompson AJ, Thompson EJ. Serum inflammatory markers and clinical/MRI markers of disease progression in multiple sclerosis. J Neurol 2001; 248:487-95.
• Ramachandran V, Church A, Giovannoni G , Bhatia K. Anti-basalganglia antibodies are absent in patients with primary blepharospasm. Neurology 2002; 58; 150.
• Dale RC, Church AJ, Cardosa F, Goddard E, Cox TC, Chong WK, Williams A, Klein NJ, Neville BG, Thompson EJ, Giovanonni G . Post-streptococcal acute disseminated encephalomyelitis with basal ganglia involvement and auto-reactive anti-basal ganglia antibodies. Ann Neurol 2001; 50;588-95.
• Derry C, Dale RC, Thom M, Miller DH, Giovannoni G . Unihemispheric cerebral vasculitis mimicking Rasmussen's encephalitis. Neurology 2002; 58;327-8.
• Petzold A, Eikelenboom MJ, Gveric D, Keir G, Chapman M, Lazeron RH, Cuzner ML, Polman CH, Uitdehaag BM, Thompson EJ, Giovannoni G . Markers for different glial cell responses in multiple sclerosis: clinical and pathological correlations. Brain 2002;125:1462-73.
• Sellebjerg F, Giovannoni G , Hand A, Madsen HO, Jensen CV, Garred P. Cerebrospinal fluid levels of nitric oxide metabolites predict response to methylprednisolone treatment in multiple sclerosis and optic neuritis. J Neuroimmunol. 2002;125:198-203.
• Dale RC, Church AJ, Benton S, Surtees RA, Lees A, Thompson EJ, Giovannoni G , Neville BG. Post-streptococcal autoimmune dystonia with isolated bilateral striatal necrosis. Dev Med Child Neurol. 2002 Jul;44(7):485-9.
• Church AJ, Cardoso F, Dale RC, Lees AJ, Thompson EJ, Giovannoni G . Anti-basal ganglia antibodies in acute and persistent Sydenham's chorea. Neurology. 2002 Jul 23;59(2):227-31.
• Dale RC, Church AJ, Surtees RA, Thompson EJ, Giovannoni G , Neville BG. Post-streptococcal autoimmune neuropsychiatric disease presenting as paroxysmal dystonic choreoathetosis. Mov Disord. 2002 Jul;17(4):817-20.
• Rejdak K, Bartosik-Psujek H, Dobosz B, Kocki T, Grieb P, Giovannoni G , Turski WA, Stelmasiak Z. Decreased level of kynurenic acid in cerebrospinal fluid of relapsing-onset multiple sclerosis patients. Neurosci Lett. 2002 Oct 4;331(1):63-5.
• Eikelenboom MJ, Petzold A, Lazeron RH, Silber E, Sharief M, Thompson EJ, Barkhof F, Giovannoni G , Polman CH, Uitdehaag BM. Multiple sclerosis: Neurofilament light chain antibodies are correlated to cerebral atrophy. Neurology. 2003 Jan 28;60(2):219-23.
• Church AJ, Dale RC, Cardoso F, Candler PM, Chapman MD, Allen ML, Klein NJ , Lees AJ, Giovannoni G . CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome? J Neuroimmunol. 2003 Mar;136(1-2):149-53.
• Rejdak K, Petzold A, Sharpe MA, Smith M, Keir G, Stelmasiak Z, Thompson EJ, Giovannoni G . Serum and urine nitrate and nitrite are not reliable indicators of intrathecal nitric oxide production in acute brain injury. J Neurol Sci. 2003 Apr 15;208(1-2):1-7.
• Trip SA, Wroe SJ, Davies G, Giovannoni G . Primary CNS mantle cell lymphoma associated with an isolated CSF monoclonal IgG band. Eur Neurol. 2003;49(3):187-8.
• Pryce G, Giovannoni G , Baker D. Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice. Neurosci Lett. 2003 May 1;341(2):164-6.
• Davies G, Keir G, Thompson EJ, Giovannoni G . The clinical significance of an intrathecal monoclonal immunoglobulin band: a follow-up study. Neurology. 2003 Apr 8;60(7):1163-6.
• Church AJ, Dale RC, Lees AJ, Giovannoni G , Robertson MM. Tourette's syndrome: a cross sectional study to examine the PANDAS hypothesis. J Neurol Neurosurg Psychiatry. 2003 May;74(5):602-7.
• Petzold A, Baker D, Pryce G, Keir G, Thompson EJ, Giovannoni G . Quantification of neurodegeneration by measurement of brain-specific proteins. J Neuroimmunol. 2003 May;138(1-2):45-8.
• Dubois BD, Keenan E, Porter BE, Kapoor R, Rudge P, Thompson AJ, Miller DH, Giovannoni G . Interferon beta in multiple sclerosis: experience in a British specialist multiple sclerosis centre. J Neurol Neurosurg Psychiatry. 2003 Jul;74(7):946-9.
• Pryce G, Ahmed Z, Hankey DJ, Jackson SJ, Croxford JL, Pocock JM, Ledent C, Petzold A, Thompson AJ, Giovannoni G , Cuzner ML, Baker D. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain. 2003 Oct;126(Pt 10):2191-202.
• Petzold A, Keir G, Green AJ, Giovannoni G , Thompson EJ. A specific ELISA for measuring neurofilament heavy chain phosphoforms. J Immunol Methods. 2003 Jul;278(1-2):179-90.
• Giovannoni G . Neutralizing antibodies during treatment of secondary progressive MS with interferon beta-1b. Neurology. 2003 Oct 14;61(7):1025.
• Dubois B, Leary SM, Nelissen I, Opdenakker G, Giovannoni G , Thompson AJ. Serum gelatinase B/MMP-9 in primary progressive multiple sclerosis patients treated with interferon-beta-1a. J Neurol. 2003 Sep;250(9):1037-43.
• Dale RC, Church AJ, Surtees RA, Lees AJ, Adcock JE, Harding B, Neville BG, Giovannoni G . Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity. Brain. 2004 Jan;127(Pt 1):21-33.
• Giovannoni G , Deisenhammer F. Neutralising antibodies against interferon beta in multiple sclerosis. Lancet. 2004 Jan 10;363(9403):166-7.
• Furrows SJ, Hartley JC, Bell J, Silver N, Losseff N, Stevenson S, Chapman M, Thompson EJ, Ridgway GL, Giovannoni G . Chlamydophila pneumoniae infection of the central nervous system in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2004 Jan;75(1):152-4.
• Miranda M, Cardoso F, Giovannoni G , Church A. Oral contraceptive induced chorea: another condition associated with anti-basal ganglia antibodies. J Neurol Neurosurg Psychiatry. 2004 Feb;75(2):327-8.
• Rejdak K, Petzold A, Sharpe MA, Kay AD, Kerr M, Keir G, Thompson EJ, Giovannoni G . Cerebrospinal fluid nitrite/nitrate correlated with oxyhemoglobin and outcome in patients with subarachnoid hemorrhage. J Neurol Sci. 2004 Apr 15;219(1-2):71-6.
• Pereira AC, Edwards MJ, Buttery PC, Hawkes CH, Quinn NP, Giovannoni G , Hadjivassiliou M, Bhatia KP. Choreic syndrome and coeliac disease: a hitherto unrecognised association. Mov Disord. 2004 Apr;19(4):478-82.
• Petzold A, Keir G, Green AJ, Giovannoni G , Thompson EJ. An ELISA for glial fibrillary acidic protein. J Immunol Methods. 2004 Apr;287(1-2):169-77
• Edwards MJ, Dale RC, Church AJ, Giovannoni G , Bhatia KP. A dystonic syndrome associated with anti-basal ganglia antibodies. J Neurol Neurosurg Psychiatry. 2004 Jun;75(6):914-6.
• Dale RC, Heyman I, Surtees RA, Church AJ, Giovannoni G , Goodman R, Neville BG. Dyskinesias and associated psychiatric disorders following streptococcal infections. Arch Dis Child. 2004 Jul;89(7):604-10.
• Church AJ, Dale RC, Giovannoni G . Anti-basal ganglia antibodies: a possible diagnostic utility in idiopathic movement disorders? Arch Dis Child. 2004 Jul;89(7):611-4.
• Lim ET, Grant D, Pashenkov M, Keir G, Thompson EJ, Soderstrom M, Giovannoni G . Cerebrospinal fluid levels of brain specific proteins in optic neuritis. Mult Scler. 2004 Jun;10(3):261-5.
• Petzold A, Brassat D, Mas P, Rejdak K, Keir G, Giovannoni G , Thompson EJ, Clanet M. Treatment response in relation to inflammatory and axonal surrogate marker in multiple sclerosis. Mult Scler. 2004 Jun;10(3):281-3.
• Edwards MJ, Trikouli E, Martino D, Bozi M, Dale RC, Church AJ, Schrag A, Lees AJ, Quinn NP, Giovannoni G , Bhatia KP. Anti-basal ganglia antibodies in patients with atypical dystonia and tics: a prospective study. Neurology. 2004 Jul 13;63(1):156-8.
• Bennett DL, McCabe DJ, Stevens JM, Mifsud V, Kitchen ND, Giovannoni G . Tumefactive neuro-Behcet disease. Neurology. 2004 Aug 24;63(4):709.
• Harrison NA, Church A, Nisbet A, Rudge P, Giovannoni G . Late recurrences of Sydenham's chorea are not associated with anti-basal ganglia antibodies. J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1478-9.
• Edwards MJ, Dale RC, Church AJ, Trikouli E, Quinn NP, Lees AJ, Giovannoni G , Bhatia KP. Adult-onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodies. Mov Disord. 2004 Oct;19(10):1190-6.
• Lim ET, Petzold A, Leary SM, Altmann DR, Keir G, Thompson EJ, Miller DH, Thompson AJ, Giovannoni G . Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a. J Negat Results Biomed. 2004 Oct 13;3(1):4.
• Rejdak K, Eikelenboom MJ, Petzold A, Thompson EJ, Stelmasiak Z, Lazeron RH, Barkhof F, Polman CH, Uitdehaag BM, Giovannoni G . CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis. Neurology. 2004 Oct 26;63(8):1439-45.
• Deisenhammer F, Giovannoni G . Longitudinal analyses of the effects of neutralizing antibodies on interferon beta-1b in relapsing/remitting multiple sclerosis. Mult Scler. 2004 Dec;10(6):713-4.
• Petzold A, Eikelenboom MJ, Keir G, Grant D, Lazeron RH, Polman CH, Uitdehaag BM, Thompson EJ, Giovannoni G . Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study. J Neurol Neurosurg Psychiatry. 2005 Feb;76(2):206-11.
• Chapman MD, Hughes LE, Wilson CD, Namnyak S, Thompson EJ, Giovannoni G . No evidence for production of intrathecal immunoglobulin G against Acinetobacter or Pseudomonas in multiple sclerosis. Eur Neurol. 2005;53(1):27-31.
• Chapman MD, Hartley JC, Furrows SJ, Ridgeway GL, Thompson EJ, Church AJ, Candler PM, Giovannoni G . Lack of serum oligoclonal antibody responses to Chlamydophila pneumoniae in multiple sclerosis. Eur Neurol. 2005;53(2):81-3.
• Martino D, Tanner A, Defazio G, Church AJ, Bhatia KP, Giovannoni G , Dale RC. Tracing Sydenham's chorea: historical documents from a British paediatric hospital. Arch Dis Child. 2005 May;90(5):507-11.
• Davies S, Nicholson T, Laura M, Giovannoni G , Altmann DM. Spread of T lymphocyte immune responses to myelin epitopes with duration of multiple sclerosis. J Neuropathol Exp Neurol. 2005 May;64(5):371-7.
• Pryce G, O'Neill JK, Croxford JL, Amor S, Hankey DJ, East E, Giovannoni G , Baker D. Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis. J Neuroimmunol. 2005 Aug;165(1-2):41-52.
• Martino D, Church AJ, Dale RC, Giovannoni G . Antibasal ganglia antibodies and PANDAS. Mov Disord. 2005 Jan;20(1):116-7.
• Martino D, Church AJ, Defazio G, Dale RC, Quinn NP, Robertson MM, Livrea P, Orth M, Giovannoni G . Soluble adhesion molecules in Gilles de la Tourette's syndrome. J Neurol Sci. 2005 Jul 15;234(1-2):79-85.
• Lim ET, Berger T, Reindl M, Dalton CM, Fernando K, Keir G, Thompson EJ, Miller DH, Giovannoni G . Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis. Mult Scler. 2005 Aug;11(4):492-4.
• Dale RC, Heyman I, Giovannoni G, Church AW. Incidence of anti-brain antibodies in children with obsessive-compulsive disorder. Br J Psychiatry. 2005 Oct;187:314-9.
• Martino D, Branson JA, Church AJ, Candler PM, Livrea P, Giovannoni G , Dale RC. Soluble adhesion molecules in acute disseminated encephalomyelitis. Pediatr Neurol. 2005 Oct;33(4):255-8.
• Lim ET, Sellebjerg F, Jensen CV, Altmann DR, Grant D, Keir G, Thompson EJ, Giovannoni G . Acute axonal damage predicts clinical outcome in patients with multiple sclerosis. Mult Scler. 2005 Oct;11(5):532-6.
• Karrenbauer VD, Leoni V, Lim ET, Giovannoni G, Ingle GT, Sastre-Garriga J, Thompson AJ, Rashid W, Davies G, Miller DH, Bjorkhem I, Masterman T. Plasma cerebrosterol and magnetic resonance imaging measures in multiple sclerosis. Clin Neurol Neurosurg 2006;108:456-460.
• Candler PM, Dale RC, Griffin S, Church AJ, Wait R, Chapman MD, Keir G, Giovannoni G , Rees JH. Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies. J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):507-12.
• Polman CH, O'Connor PW, Havrdova E, Hutchinson M, Kappos L, Miller DH, Phillips JT, Lublin FD, Giovannoni G , Wajgt A, Toal M, Lynn F, Panzara MA, Sandrock AW; AFFIRM Investigators. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med. 2006 Mar 2;354(9):899-910.
• Dale RC, Candler PM, Church AJ, Wait R, Pocock JM, Giovannoni G . Neuronal surface glycolytic enzymes are autoantigen targets in post-streptococcal autoimmune CNS disease. J Neuroimmunol. 2006 Mar;172(1-2):187-97.
• Calabresi PA, Giovannoni G, Confavreux C, et al. The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL. Neurology 2007;69:1391-1403.
• Giovannoni G, Barbarash O, Casset-Semanaz F, et al. Immunogenicity and tolerability of an investigational formulation of interferon-beta1a: 24- and 48-week interim analyses of a 2-year, single-arm, historically controlled, phase IIIb study in adults with multiple sclerosis. Clin Ther 2007;29:1128-1145.
• Maresz K, Pryce G, Ponomarev ED, et al. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med 2007;13:492-497.
• Rudick RA, Miller D, Hass S, et al. Health-related quality of life in multiple sclerosis: effects of natalizumab. Ann Neurol 2007;62:335-346.