Home| Professor of Neuropathology |
Publications since 2001
• G. Yadirgi, V. Leinster, S. Acquati, H. Bhagat, O. Shakhova and S. Marino. Conditional activation of Bmi1 expression regulates self-renewal, apoptosis and differentiation of neural stem/progenitor cells in vitro and in vivo. Stem Cells. 2011 Feb 8. doi: 10.1002/stem.614. [Epub ahead of print]
• T. Subkhankulova, X. Zhang, C. Leung and S. Marino. Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors. Mol Cell Neurosci. 2010 Oct;45(2):151-62. Epub 2010 Jun 20.
• R. Sutter, O. Shakhova, C. Sutter, S. Penkar, H. Bhagat, A. Santuccione, R. Bernays, F. L. Heppner, U. Schüller, M. Grotzer, H. Moch, P. Schraml and S. Marino. Cerebellar stem cells act as medulloblastoma initiating cells in a mouse model and a neural stem cell signature characterises a subset of human medulloblastoma. Oncogene 2010 Mar 25;29(12):1845-56.
• O. Shakhova, C. Leung, E. van Montfort, A. Berns and S. Marino. Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastzomas through amplification of N-Myc and Ptc2. Cancer Research 2006; 66 5190-5200
• S. Bruggeman, M. Lingbeek, P. van der Stoop, J. Jacobs, K. Kieboom, E. Tanger, D. Hulsman, C. Leung, S. Marino and M. van Lohuizen. Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1 deficient mice. Genes & Development 2005; 19:1438-1443
• C. Leung, M. Lingbeek, O. Shakhova, J. Liu, E. Tanger, P. Saremaslani, M. van Lohuizen, S. Marino. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas Nature 2004; 428(6980):337-41
• JF Roth, N. Shikama, C. Henzen, I. Debaillets, W. Lutz, S. Marino, J. Wittwer, H. Schorle, M. Gassmann, R. Eckner. Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. EMBO J 2003; 22(19):5186-96
• N. Shikama, W. Lutz, R. Kretzschmar, N. Sauter, JF Roth, S. Marino, J. Wittwer, A. Scheidweiler, R. Eckner. Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J 2003; 22(19):5175-85
• M. Sibilia , B. Wagner , A. Hoebertz , C. Elliott, S. Marino , W. Jochum, EF Wagner. Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. Development, 2003 130(19):4515-25
• S. Marino, D. Hoogervoorst, S. Brandner and A. Berns. Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence. Development, 2003,130(15):3359-68
• U. Schwarz, S. Marino and K. Hess Marburg's encephalitis in a young woman. European Neurology, 2002 48(1):42-4
• J.W.Voncken, B.A.J. Roelen, M.Roefs, S. de Vries, E. Verhoeven, S. Marino, J. Deschamps and M. van Lohuizen. (2003) Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. PNAS, 2003; 100(5):2468-73.
• S. Marino, P. Krimpenfort, C. Leung, H. van der Korput, J. Trapman, I. Camenisch, A. Berns and S. Brandner. PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development, 2002 129(14):3513-3522