Home| Professor of Human Genetics |
Publications since 2001
• Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ, Wyllie AH, Edwards PA. (2001) Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangements. Proc Natl Acad Sci U S A . 98(5):2538-43.
• Shiels C, Islam SA, Vatcheva R, Sasieni P, Sternberg MJE, Freemont PS, Sheer D. (2001) PML bodies associate with the MHC gene cluster. Journal of Cell Science 114 (20): 3705-3716.
• Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PA, Lemoine NR. (2001) Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. International Journal of Cancer 91(3):350-8.
• Volpi EV, Sheer D, Uhlmann F. (2001) Cohesion, but not too close. Current Biology 11(10):R378.
• Donev RM, Doneva TA, Bowen WR, Sheer D. (2002) hnRNP-A1 binds directly to double-stranded DNA in vitro within a 36bp sequence Molecular and Cellular Biochemistry 233: 181-185.
• Williams RRE, Broad S, Sheer D, Ragoussis J. (2002) Sub-chromosomal positioning of the epidermal differentiation complex (EDC) in keratinocyte and lymphoblast interphase nuclei. Experimental Cell Research 272:163-175
• Donev R, Horton R, Beck S, Doneva T, Vatcheva R, Bowen WR, Sheer D. (2003) Recruitment of heterogeneous nuclear ribonucleoprotein A1 in vivo to the LMP/TAP region of the Major Histocompatibility Complex. Journal of Biological Chemistry 278(7):5214-26
• Wang J, Shiels C, Sasieni P, Wu PJ, Islam SA, Freemont PS, Sheer D. (2004) Promyelocytic leukemia nuclear bodies associate with transcriptionally active genomic regions. Journal of Cell Biology 164(4):515-526.
• Enukashvily N, Donev R, Sheer D, Podgornaya O. (2005) Satellite DNA binding and cellular localisation of RNA helicase P68. Journal of Cell Science 118(3):611-22.
• Sheer D, Shipley J (2005) Molecular Cytogenetics of Cancer. In: Introduction to the Cellular and Molecular Biology of Cancer, 4th Edition. M. Knowles and P. Selby (eds.), Oxford University Press: pp. 95-116.
• Mulholland PJ, Fiegler H, Mazzanti C, Gorman P, Sasieni P, Adams J, Jones TA, Babbage JW, Vatcheva R, Ichimura K, East P, Poullikas C, Collins VP, Carter NP, Tomlinson IPM, Sheer D. (2006) Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme. Cell Cycle 5(7):783-791.
• Newall AET, Wang J, Sheer D. (2006) Nuclear Compartments. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine, Springer Berlin Heidelberg , Part 14, pp 1309-1313.
• Donev R, Newall A, Thome J, Sheer D. (2007) A role for Sc35 and hnRNPA1 in the determination of Amyloid Precursor Protein isoforms. Molecular Psychiatry 12(7): 681-690.
• Christova R, Jones T, Wu P-J, Bolzer A, Costa-Pereira AP, Watling D, Kerr IM and Sheer D. (2007) P-STAT1 mediates higher-order chromatin remodelling of the human Major Histocompatibility Complex in response to IFN- g . Journal of Cell Science 20(18):3262-3270.
• Takousis P, Johonnett P, Williamson J, Sasieni P, Warnes G, Forshew T, Azuara V, Fisher A, Wu PJ, Jones T, Vatcheva R, Beck S, Sheer D. (2007) Replication Timing Profile Reflects the Distinct Functional and Genomic Features of the MHC Class II Region. Cell Cycle 6(19):2393-2398.
• Ottaviani D, Lever E, Takousis P, Sheer D. (2008) Anchoring the genome. Genome Biology 9(1):201.
• Ottaviani D, Lever E, Mitter R, Jones T, Forshew T, Christova R, Tomazou, Rakyan VK, Krawetz SA, Platts AE, Segarane B, Beck S, Sheer D (2008) Reconfiguration of genomic anchors upon transcriptional activation of the human MHC. Genome Research 18: 1778-1786.
• Tomazou, E.M., V.K. Rakyan, G. Lefebvre, R. Andrews, P. Ellis, D.K. Jackson, C. Langford, M.D. Francis, L. Backdahl, M. Miretti, P. Coggill, D. Ottaviani, D. Sheer, A. Murrell, and S. Beck. (2008) Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis. BMC Med Genomics 1: 19.
• Bax DA, Little SE, Gaspar N, Perryman L, Marshall L, Viana-Pereira M, Jones TA, Williams RD, Grigoriadis A, Vassal G, Workman P, Sheer D, Reis RM, Pearson AD, Hargrave D, Jones C (2009) Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development. PLoS ONE.;4(4):e5209.
• Forshew T, Tatevossian RG, Lawson AR, Ma J, Neale G, Ogunkolade BW, Jones TA, Aarum J, Dalton J, Bailey S, Chaplin T, Carter RL, Gajjar A, Broniscer A, Young BD, Ellison DW, Sheer D (2009) Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. J Pathol. 218(2):172-81.
• Lever E, Sheer D (2010) The role of nuclear organization in cancer. J Pathol 220 (2):114-125
• Tatevossian RG, Lawson AR, Forshew T, Hindley GF, Ellison DW, Sheer D (2010) MAPK pathway activation and the origins of pediatric low-grade astrocytomas. J Cell Physiol. 222(3):509-14.
• Lawson AR, Tatevossian RG, Phipps KP, Picker SR, Michalski A, Sheer D, Jacques TS, Forshew T. (2010) RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort. Acta Neuropathol. 120, 271-273.
• Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM (2010) Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. Nature 465(7299):813-7