Home| Senior Lecturer |
Contact details:
| Tel: | +44 20 7609 8202/8009 |
| Fax: | +44 20 7609 8200/ 8224 |
| Email: | s.g.agrawal@qmul.ac.uk |
| Address: | Academic Haematology Unit,, |
Biography
UK trained Haemato-Oncologist - qualified from Bristol and London .
PhD - University of Paris in Tumour Immunology.
Director for Leukaemia Immunophenotyping, Stem Cell Processing and clinical lead for CLL.
My specialist interests are in:
• diagnostic morphology and immunophenotyping of leukaemia;
• -allogeneic transplantation; fungal infections; CLL
• management of chemotherapy-associated anaemia
I am PI of a national randomized study looking at growth factor therapy in low-risk myelodysplastic syndrome.
Other clinical studies in:
- CLL; anaemia management; early diagnosis of invasive fungal infections; stem cell therapy for ischaemic heart disease (in collaboration with Dr Anthony Mathur)
Member of NICE reviews on: IOG for Haematological malignancies; Assessment of EPO for cancer treatment induced- anaemia; Anaemia management in chronic kidney disease
Research Activity
Chronic lymphocytic leukaemia:
• new diagnostic and prognostic markers; novel tumour-specific marker for minimal residual disease
• biology of CLL cells - role of Bax instability in tumour escape from apoptosis; role of proteasome inhibition to reverse this (collaboration with Dr L. Jia)
• biology of CLL cells - role of CD160 (an MHC ligand) in proliferation and tumour stimulation by infection (CMV)
• biology of CLL- role of IL3
Endothelial progenitor cells:
• state of the art flow cytometric detection of EPC
• defining EPC levels in health and disease (cardiac, renal, bowel, critical lung injury, pregnancy) (Trust-wide collaborations)
• cell subtypes and stem cell / EPC potential in blood and marrow of cardiac patients
Key Publications
• Anna Dulic-Sills *1 , Mark J Blunden *2 , Joel Mawdsley 4 , Anthony Bastin 3 , Danny McAuley 3 , Mark Griffiths 5 , David S Rampton 4 , Magdi M Yaqoob 2 , Marion G Macey and Samir G Agrawal 1 ,6 New flow cytometric technique for the evaluation of circulating endothelial progenitor cell levels in various disease groups. J Immunol Methods 2006 Oct 20; 316 ( 1-2 ): 107-15
• Lisa J Griffiths 1 , Martin Anyim 1 , Sarah R Doffman 2 , Mark Wilks 1# , Michael R Millar 1 , Samir G Agrawal . Comparison of DNA extraction methods from Aspergillus fumigatus using Real Time PCR . J Med Microbiol 2006; 55(9):1187-91 .
• Oakervee HE, Popat R, Curry N, Smith P, Morris C, Drake M, Agrawal S , Stec J, Schenkein D Esseltine D-L and Cavenagh JD . PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma . British Journal of Haematology, 2005 , 129, 755-762
• Feng WY, Liu FT, Patwari Y, Agrawal SG , Newland AC, Jia L. BH3-domain mimetic compound BH3I-2' induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria . Br J Haematol. 2003 ; 121: 332-40.
• Agrawal SG , Marquet J, Plumas J, Rouard H, Delfau-Larue M-H, Gaulard P, Boumsell L, Reyes F, Bensussan A and Farcet J-P. Multiple costimulatory signals are required for triggering proliferation of T cells from human secondary lymphoid tissue . Int Immunol 2001 ;13(4):441-50.
• Agrawal S , Marquet J, Freeman G, Tawab A, Le B outeiller P, Roth P, Bolton W, Ogg G, Boumsell L, Bensussan A. MHC class I triggering by a novel cell surface ligand costimulates the proliferation of activated human T cells. J Immunol, 'Cutting Edge' section 1999; 162 : 1223 - 1226.
• Agrawal S , Marquet J, Delfau-Larue MH, Copie-Bergman C, Jouault H, Reyes F, Bensussan A and Farcet JP. CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and non malignant secondary lymphoid organs. J Clin Invest 1998 ; 102 : 1715 - 1723.
