Home| Professor of Cardiovascular Mechanics |
Contact details:
| Tel: | +44 20 3246 0178 |
| Fax: | +44 20 3246 0216 |
| Email: | s.e.greenwald@qmul.ac.uk |
| Address: | BICMS Pathology Group, |
Biography
Following a BA in Natural Science at Hertford College Oxford in 1971 and a PhD in Medicine (Pathology) from Guy's Hospital Medical School (1975), Steve Greenwald obtained a British Heart Foundation Junior Research Fellowship working on arterial elasticity in children. This was followed by a position as research assistant in the Pathology Department of The London Hospital Medical College investigating the relationship between arterial structure and mechanical properties and how this relationship is modified by vascular disease. He has been on the academic staff of The Medical College since 1980 and obtained a personal chair in Cardiovascular Mechanics in 2001. Since 2002 he has been head of intercalated degrees and an Associate Director of The Interdisciplinary Research Centre in Biomedical Materials at Queen Mary University of London. He was elected as the Vice President of the International Society of Pathophysiology in 2006.
Research Activity
Current research interests include a search for mechanical factors in the genesis of arterial disease, with emphasis on the role of fatigue failure in arterial elastin, foetal programming of essential hypertension and wave propagation in arteries. The link between the elastic properties of arteries, pulse pressure and the mechanical load on the heart is now thought to be the explanation, at least in part, for the widely recognised association between raised vascular stiffness and increased risk of cardiovascular morbidity and mortality. On the applied side, the interest in arterial mechanical properties has lead to studies evaluating the efficacy compliant intravascular stents and the development of a novel optical method for the non-invasive measurement of arterial compliance. The possibility of applying similar optical techniques to the measurement of cardiac output and the assessment of endothelial function is now under active investigation.
Key Publications
• Greenwald, S.E., Moore , J.E., Rachev, A., Kane, T.C.P., and Meister, J.-J., Experimental investigation of residual strains in the artery wall. J. of Biomech. Eng. , 1997. 119: 438-444.
• Martyn, C.N. and Greenwald, S.E., Impaired synthesis of elastin in the walls of the aorta and large conduit arteries during early development may be an initiating event in the pathogenesis of systemic hypertension. Lancet, 1997. 350: 953-955.
• Greenwald, S.E. and Berry , C.L., Improving vascular grafts: the importance of mechanical and haemodynamic properties. Journal of Pathology, 2000. 190: 292-299.
• Stergiopulos, N., Vulliemoz, S., Rachev, A., Meister, J.J., and Greenwald, S.E., Assessing the homogeneity of the elastic properties and composition of the pig aortic media. Journal of Vascular Research, 2001. 38: 237-246.
• Greenwald, S.E., Pulse pressure and arterial elasticity. Quarterly Journal of Medicine, 2002. 95: 107-112.
• Loukogeorgakis, S., Dawson , R., Phillips, N., Martyn, C.N., and Greenwald, S.E., Validation of a device to measure arterial pulse wave velocity by a photoplethysmographic method. Physiological Measurement, 2002. 23: 581-596
• Rachev, A. and Greenwald, S.E., Residual strains in conduit arteries. Journal of Biomechanics, 2003. 36: 661-670.
• Gardiner, H.M., Taylor , M.J., Karatza, A., Vanderheyden, T., Huber, A., Greenwald, S.E., Fisk , N.M. , and Hecher, K., Twin-twin transfusion syndrome: the influence of intrauterine laser photocoagulation on arterial distensibility in childhood. Circulation, 2003. 107: 1906-1911.
• Greenwald, S.E., Ageing of the conduit arteries. J Pathol, 2007. 211: 157-172.
