Home| Senior Lecturer |
Contact details:
| Tel: | +44 20 7882 2280 |
| Fax: | +44 20 7882 2183 |
| Email: | l.jia@qmul.ac.uk |
| Address: | Academic Haematology Unit,, |
Biography
Li Jia started her research career after graduating from medical school in 1983. For 11 years, she worked in the Institute of Haematology , Chinese Academy of Medical Science as a medical scientist, received full trainings in both laboratory techniques and research methodologies.
In 1994, she jointed the Department of Haematology , QMUL, as a PhD student. During her post-doctoral research period (1997-1999), she was supported by Leukaemia Research Fund, continued to develop her research interesting in the apoptosis field, focusing on the roles of the Bcl-2 family of proteins. In 1999, she spent two months working, as a research fellow, in one of the world top apoptosis laboratory, the apoptosis center in Kimmel Cancer Institute, Thomas Jefferson University ( Philadelphia , USA).
In 2000, Li Jia was appointed as a lecturer and established her own research group working on apoptosis. In 2004, she was appointed as a senior lecturer by the Blizard Institute of Cell and Molecular Science, QMUL.
Research Activity
The research interests are cellular and molecular mechanisms of cell death and application in the treatment of human leukaemia. Her current work focuses on understanding the regulation of Bcl-2 family of proteins (Bax) by proteasome and implication in the prognosis of chronic lymphocytic leukaemia (CLL) and developing novel anti-cancer compounds based on nutural occurring peptide.
Key Publications
• Hao J.H., Yu M., Liu F.T., Newland A.C. and Jia L. (2004) Bcl-2 inhibitors sensitize TRAIL-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic cells. Cancer Res. 64:3607-3616.
• Liu F.T., Lindsey K. G., Hao J.H., Newland A.C., and Jia L. (2004) Increase in the ratio of mitochondrial Bax/Bcl-XL sensitises leukemic K562 cells to DNA damage-induced apoptosis. Apoptosis 9:377-384.
• Liu, F.T., Newland, A.C., and Jia L. (2003) Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. Biochem. Biophys. Res. Commun. 310:956-962.
• Jia L., Patwari Y., Kelsey S.M., Srinivasula S.M., Agrawal S.G., Alnemri E.S., and Newland A.C. (2003) Role of Smac in human leukemic cell apoptosis and proliferation. Oncogene 22:1589-99 .
• Fu W.N., Bertoni F., Kelsey S.M., McElwaine S.M., Cotter F.E., Newland A.C., and Jia L. (2003) Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia. Oncogene 22:451-455.
• Jia L., Srinivasula S.M., Liu F.T., Newland A.C., Fernandes-Alnemri T., Alnemri E.S. and Kelsey S.M. (2001) Deficiency of Apaf-1 protein confers resistance to cytochrome c -dependent apoptosis in human leukemic cells . Blood 98:414-421.
• Jia L., Patwari Y., Srinivasula S.M., Newland A.C., Fernandes-Alnemri T., Alnemri E.S. and Kelsey S.M. (2001). Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis. Oncogene 20: 4871-4826.
• Jia L., Macey M.G., Yin Y., Newland A.C. and Kelsey S.M. (1999) Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemic cells undergoing apoptosis. Blood. 93:2353-2359.
• Jia L., Doumashikin R.R., Newland A.C. and Kelsey S.M. (1997) Mitochondrial ultracondensation, but not swelling, is involved in TNF a -induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia Res. 21:973-983.
• Jia L., Kelsey S.M., Grahn. M.F., Newland A.C. (1996) Increased activity and sensitivity of mitochondrial respiratory enzymes to TNF a -induced inhibition is associated with cytotoxicity in drug-resistant leukaemic cell lines. Blood, 87:2401-2410.
