Home| Professor of Haematology |
| Lead, Academic Haematology Unit |
Contact details:
| Tel: | +44 20 7882 2274 |
| Fax: | +44 20 7882 2183 |
| Email: | a.c.newland@qmul.ac.uk |
| Address: | Academic Haematology Unit,, |
Biography
PRESENT APPOINTMENTSProfessor of Haematology, Barts and the London School of Medicine and Dentistry, since November 1995. Appointed to the chair at the London Hospital Medical College in 1992.
Honorary Consultant, Barts and the London NHS Trust. Original appointment from August 1981 at the London Hospital
Director, North East Thames Cancer Network, 2001- current
Associate Director of Pathology, Barts and the London NHS Trust, 2004 - current
Head, Division of Haematology, Oncology and Imaging. 1998-2003, Medical and Dental School .
Director of Research and Development, Barts and the London NHS Trust, 1997 - 2001
Appointed Teacher - Pathology (Faculty of Medicine), University of London . Since June 1988.
OTHER SCIENTIFIC APPOINTMENTS
1) DoH National Advisor on Clinical Scientist appointments, since 1990.
2) Advisor to the Pesticides registration section (Advisory Committee on Pesticides) of the Health and Safety Executive, 1992.
3) Honorary Consultant to the Royal Army Medical Corp, since 1994.
4) Honorary Consultant, Trial Monitoring Committee, Scottish Blood Transfusion Service, since 1998.
5) Member, National Blood Commissioning Group (DoH),1998-current
6) Member, National Transfusion Committee, 2000-current.
7) Specialist Training Authority Appeal Panel, 2000-current.
8) Member. NHS R&D Management Forum. 2001-2002.
9) Haematology representative on the Medical Workforce Advisory group1999-current
10) Member of the Specialist Services Definition set (No 25 - Specialist Pathology), 2002
11) Haematology lead, NE Thames Pathology Workforce Confederation and for Pathology Modernisation, 2002
12) Chair, London Cancer New Drugs Group, 2002
13) Member, National Cancer Director's National Chemotherapy Advisory Group, 2003
14) Member of the National Cancer Director's Clinical Directors Management Group, 2003
15) Member, DoH Pathology Modernisation Oversight Monitoring Group, 2004
AWARDS
The Bhagwan Singh Fellowship, 1993, The Royal College of Pathologists.
COMMITTEES
Royal Colleges
1) President, Royal College of Pathologists, 2005 - current and member of the Executive Committee. Also member of the Council from 1993-96 and 1999-2002.
2) Chairman, International Committee, Royal College of Pathologists
3) Chairman, Research Committee, Royal College of Pathologists.
4) Royal College of Physicians - Standing Committee of Members
(Haematology subcommittee) 1979-1985
5) Chairman, Standing Advisory Committee on Haematology, Joint Committee on Higher Medical Training. 1996-2000, Secretary, 1993-96, Member, 1991-93.
6) Chairman, Intercollegiate Committee on Haematology, 2000- current
7) Member, Professional Performance Committee, RCPath, 2000-current
8) Member, Standing Advisory Committee on Haematology 1991-1996
Cancer Related
1)NCRI (previously MRC) Trials Leukaemia Working Party Member, 1991-current.
2)Member, Medical and Scientific Panel, Leukaemia Research Fund, 1993-96
3)Intercollegiate Committee on Oncology. 1994-1998 (Co-chairman 95-96).
4)British National Lymphoma Investigation, Regional Representative (North East Thames - Tower Hamlets), 1985-2000.
5)U.K. Co-ordinating Committee on Cancer Research (Bone Marrow Transplant subcommittee), 1987-1997.
6)Member, Scientific Advisory Panel, Institute of Cancer Research ,1995-current
7)Campaign for Effective and Rational Treatment - Steering Committee Member, 2000-current.
8)East London R&D Network, Cancer sub-group, Chairman, 2000 - 2004.
9)CHI/Audit Commission National review of the Implementation of Calman/Hine and Cameron reports on Cancer Services, 2001.
Trust and School
1)1992 - current, Member, Research Advisory Committee, Special Trustees, Vice-Chairman, 2000-04.
2)1993-1994, Chairman, Academic Board, London Hospital Medical College .
3) Member, Trust Cancer Task Force for the implementation of the Calman-Hine Report.
4)1997-current, Member, School Research Board.
5)1997-2002, Chairman, Trust Research Advisory Committee.
6)1998-2003, Member, Warden's School Strategy, Planning and Resources Committee.
7) 2003 - current, Member of the Queen Mary, University of London Council .
LEARNED SOCIETIES
1) President , British Society for Haematology, 1998 - 1999.
Scientific Secretary, BSH 1989 - 1996, Committee member 1988-91
2)Chairman, British Society for Haematology Conferences Ltd 1996-1999
3)Chairman, Association of Professors and Clinical Heads of Academic Departments of Haematology, 1994-current.
4)International Society of Haematology; Chairman, Education and Training Committee, 2000-current; European Councillor 1996-current
5)European Union of Medical Specialities (previously Monospecialities), UK (BMA) representative, Biopathologie, 2000-current.
6) Member of the Advisory Board of the European Council for Accreditation in Haematology, 2003-current
Member
American Society of Haematology
Association of Physicians
Association of Clinical Professors
British Medical Association
British Blood and Bone Marrow Transplant Society
British Blood Transfusion Society
British Society for Haematology
British Society for Immunology
European Bone Marrow Transplant Group
International Medical Club
International Society of the Immunocompromised Host
International Society of Haematology
PATIENT SUPPORT GROUPS
Vice President, Leukaemia Care Society.
Specialist Advisor, CancerBACUP
Medical Advisor, ITP Patient Support Group
Thalassaemia Society - Patron and Medical Member of Committee
EDITORIAL ACTIVITIES
Editor in Chief - Hematology - 1995 - current
Assistant Editor - British Journal of Haematology 1987 - 1997
Editorial Board _ British Journal of Haematology 1998 - 2000
Editorial Board - Cancer Topics 1986 - current
Editorial Board - Clinical Laboratory Haematology 1980- current
Editorial Board - Journal of Chemotherapy - 1994 - current.
Editor - " Reviews in Haematological Oncology" Cambridge University Press - 1990 - 1996
Research Activity
My research group has 3 main aims which it continues to develop:
The immunology of autoimmune thrombocytopenia
The cell biology of autoimmune thrombocytopenia
The contribution of proapoptotic molecules including Bax to leukaemia development
Key Publications
• Provan D, Moss AJ, Newland AC, Bussel JB. Efficacy of mycophenolate mofetil as single-agent therapy for refractory immune thrombocytopenic purpura. Am J Hematol. 2006 Jan;81(1):19-25.
• Johansson U, Lawson C, Dabare M, Syndercombe-Court D, Newland AC, Howells GL, Macey MG. Human peripheral blood monocytes express protease receptor-2 and respond to receptor activation by production of IL-6, IL-8, and IL-1{beta}. J Leukoc Biol. 2005 Oct;78(4):967-75. Epub 2005 Jul 6.
• Johansson U, Macey MG, Kenny D, Provan AB, Newland AC. The role of natural killer T (NKT) cells in immune thrombocytopenia: is strong in vitro NKT cell activity related to the development of remission? Br J Haematol. 2005 May;129(4):564-5. No abstract available.
• Stasi R, Rossi Z, Stipa E, Amadori S, Newland AC, Provan D. Helicobacter pylori eradication in the management of patients with idiopathic thrombocytopenic purpura. Am J Med. 2005 Apr;118(4):414-9.
• Liu FT, Goff LK, Hao JH, Newland AC, Jia L. Increase in the ratio of mitochondrial Bax/Bcl-XL induces Bax activation in human leukemic K562 cell line. Apoptosis. 2004 May; 9(3):377-84.
• Johansson U, Macey MG, Kenny D, Provan D, Newland AC. Alpha-galactosylceramide-driven expansion of human natural killer T cells is inhibited by prednisolone treatment.
Br J Haematol. 2004 May;125(3):400-4.
• Hao JH, Yu M, Liu FT, Newland AC, Jia L. Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells. Cancer Res. 2004 May 15;64(10):3607-16.
• Jia L, Patwari Y, Kelsey SM, Srinivasula SM, Agrawal SG, Alnemri ES, Newland AC. Role of Smac in human leukaemic cell apoptosis and proliferation. Oncogene. 2003 Mar 20;22(11):1589-99.
• Newland AC. Treatment of adults with autoimmune thrombocytopenic purpura. Lancet. 2002 Jan 5;359(9300):4-5. No abstract available.
• Fu WN, Bertoni F, Kelsey SM, McElwaine SM, Cotter FE, Newland AC, Jia L. Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia.
Oncogene. 2003 Jan 23;22(3):451-5.
