Dr Adrian Martineau, B Med Sci, DTM&H, MRCP
Senior Lecturer in Respiratory Infection and Immunity
email: a.martineau@qmul.ac.uk
Phone: +44 20 7882 2551
Fax: +44 20 7882 2552
Centre for Primary Care and Public Health
Barts and The London School of Medicine and Dentistry
Postal address:
2 Newark Street
Whitechapel
London
E1 2AT
Adrian gained a B Med Sci degree in Epidemiology and Public Health from Newcastle University in 1995, and graduated from Newcastle Medical School in the following year. Following house jobs in Northumberland and Glasgow, he gained a Diploma in Tropical Medicine and Hygiene from Liverpool University before spending 18 months working as a Medical Officer in South Africa. He returned to Liverpool to complete medical training in 1999, and became a member of the Royal College of Physicians in 2001. Adrian joined Queen Mary as a lecturer in Respiratory Medicine in 2002, and established a programme of laboratory and clinical research into the immunomodulatory actions of vitamin D in tuberculosis. He is currently conducting clinical trials of vitamin D supplementation in patients with asthma and COPD, and in residents and staff in sheltered housing.
Research interests:
Adrian’s research focuses on immunomodulatory actions of vitamin D in tuberculosis, asthma, chronic obstructive airways disease and upper respiratory tract infection. This translational programme of work combines in vitro investigation with a series of multi-centre clinical trials, investigating potential utility of vitamin D supplementation as an adjunct in the treatment of tuberculosis, and in the prevention of upper respiratory tract infections and exacerbations of asthma and chronic obstructive pulmonary disease.
Publications:
(2011) Martineau AR, Timms PM, Bothamley GH, et al. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet. Jan 15;377(9761):242-250.
Martineau AR, Leandro AC, Anderson ST, Newton SM, Nicol MP, Pienaar SM, Skolimowska KH, Rocha MA, Rolla VC, Levin M, Davidson RN, Bremner SA, Griffiths CJ, Eley BS, Bonecini-Almeida MG, Wilkinson RJ. Association between Gc genotype and susceptibility to tuberculosis is dependent on vitamin D status. Eur Resp J in press 2009.
Coussens A, Timms PM, Boucher BJ, Venton TR, Ashcroft A, Newton SM, Wilkinson KA, Davidson RN, Griffiths CJ, Wilkinson RJ, Martineau AR. 1,25-dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection. Immunology 2009 Aug;127(4):539-48.
Wilkinson KA, Newton SM, Stewart GR, Martineau AR, Patel J, Sullivan SM, Herrmann JL, Neyrolles O, Young DB, Wilkinson RJ. Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis. BMC Microbiol. 2009 May 14;9:93.
Martineau AR, Nanzer AM, Satkunam K, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Wilkinson RJ, Griffiths CJ. Influence of a single oral dose of vitamin D2 on serum 25-hydroxyvitamin D concentrations in tuberculosis patients. Int J Tuberc Lung Dis. 2009;13:119-25.
Newton SM, Mackie SL, Martineau AR, Wilkinson KA, Kampmann B, Fisher C, Dutta S, Levin M, Wilkinson RJ, Pasvol G. Reduction of chemokine secretion in response to mycobacteria in infliximab-treated patients. Clin Vaccine Immunol 2008;15:506-512.
Martineau AR, Newton, SM, Wilkinson KA, Kampmann B, Hall BR, Nawroly N, Packe GE, Davidson RN, Griffiths CJ, Wilkinson RJ. Neutrophil-mediated innate immune resistance to mycobacteria. J Clin Invest 2007;117:1988-94
Martineau AR, Wilkinson KA, Newton SM, Norman AW, Packe GE, Skolimowska K, Davidson RN, Kampmann B, Griffiths CJ, Wilkinson RJ. Interferon gamma- and tumour necrosis factor-independent vitamin D-inducible human suppression of mycobacteria by cathelicidin LL-37. J Immunol 2007;178:7190–7198
Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ. A single dose of vitamin D enhances immunity to mycobacteria. Am. J Respir. Crit Care Med 2007;176:208-13
Griffiths CJ, Sturdy P, Brewin P, Bothamley GH, Eldridge S, Martineau AR, McDonald M, Ramsay J, Tibrewal S, Levi S, Zumla A, Feder G. Educational outreach to promote screening for tuberculosis in primary care: a cluster randomised controlled trial. Lancet 2007;369:1528–34
Martineau AR, Honecker F, Wilkinson RJ, Griffiths CJ. Vitamin D in the treatment of pulmonary tuberculosis. J. Steroid Biochem Mol Biol 2007;103: 793–798
Newton SM, Smith RJ, Wilkinson KA, Garton NJ, Staples KJ, Ziegler-Heitbrock L, Stewart GR, Wain JR, Nicol MP, Martineau AR, Al-Obaidi A, Shafi J, Levin M, Rajakumar K, Andrew PW, Barer MR, Wilkinson RJ. Phenotypic characterization and genetic reconstruction of an outbreak strain of Mycobacterium tuberculosis. Proc Nat Acad Sci USA 2006; 103(42): 15594-8.
Martineau A, Lowey H, Tocque K, Davies P. Decreasing tuberculosis case fatality in England and Wales, 1988-2001. Int J Tuberc Lung Dis.2004;8(6):737-42.
Scholvinck E, Wilkinson KA, Whelan AO, Martineau AR, Levin M, Wilkinson RJ. Interferon-based immunodiagnosis of tuberculosis: comparison between whole blood and ELISPOT methods. J Clin Microbiol. 2004;42(2):829-31.
Craig M, Bredenkamp B, Vaughan-Williams H, Rossouw E, Kelly V, Martineau A, Henry G. Field and laboratory comparative evaluation of ten rapid malaria diagnostic tests. Trans R Soc Trop Med Hyg 2002;96(3): 258-65.
Martineau AR, Beeching NJ, Nye FJ, Croall J, Amadi AA. Serum and pericardial fluid bactericidal assays in a patient with staphylococcal pericarditis. J Infect. 2001; 43(2):158-9.
Martineau A, White M. What’s not in a name: accuracy of ascribing south Asian ethnic identity using first and second names. J Epidemiol. Community Health 1998; 52: 336-7.
Martineau A, White M, Bhopal R. No sex differences in immunisation rates of British south Asian children: the effect of migration? Brit Med J 1997; 314: 642-3.