Professor Sandra Eldridge, BA, MSc, PhD
Professor of Biostatistics, Joint Centre Lead
email: s.eldridge@qmul.ac.uk
Phone: +44 20 7882 2519
Fax: +44 20 7882 2552
PA: Lynette Edwards
Tel: +44 20 7882 2509
gppc-admin@qmul.ac.uk
Sandra gained a degree in Mathematics from Oxford University in 1979. She then spent two years teaching mathematics in secondary schools, first in Nigeria with Voluntary Service Overseas, then in the UK.
In 1982 she completed an MSc in Medical Demography at the London School of Hygeine and Tropical Medicine where she worked for several years before moving to London Metropolitan University (formerly City of London Polytechnic) to teach undergraduate statistics. She joined Queen Mary as a lecturer in medical statistics in 1994, working predominantly in primary care. She developed an interest in cluster randomised trials and completed a doctorate focusing on these trials in 2005.
She currently carries out methodological research on cluster randomised trials, collaborative research with colleagues at the Institute for Health Sciences, within the Barts and the London Medical school and more widely, as well taking the lead in several postgraduate teaching modules. She was instrumental in setting up the Royal Statistical Society Primary Health care study group in 2002.
She is currently joint Centre Lead, Director of the UKCRC registered and funded Pragmatic Clinical Trials Unit, and joint lead for the Barts and The London arm of the Research Design Service London.
Research interests:
Sandra's main research interests are cluster randomised trials and complex interventions. She has published the largest and most comprehensive review of the methodology of cluster randomised trials to date, and a paper describing practical ways of allowing for variable cluster size in sample size calculations for cluster randomised trials. More recently she has become interested in developing methods to improve the design of cluster randomised trials of complex interventions, specifically methods of modelling available data in pilot studies to try and identify weaknesses in putative interventiions, and she is now leading the development of a collaborative group to explore this methodology; this group involves researchers from QMUL, UCL, City University, Sheffield, Warwick, Oxford, Melbourne (Australia) and Calgary (Canada). In addition to her methodological research she has responsibility for the statisical design and analysis aspects of a large number of collaborative research projects mostly concerned with the management of chronic conditions; many of these projects involve cluster randomised trials.
Publications:
2010
ASCOT.Ethnic differences in blood pressure response to first and second-line antihypertensive therapies in patients randomized in the ASCOT TrialGupta AK, Poulter NR, Dobson J, Eldridge S, Cappuccio FP, Caulfield M, Collier D, Cruickshank JK, Sever PS, Feder G. Am J Hypertens. 2010 Sep;23(9):1023-30.
The translation research in a dental setting (TRiaDS) programme protocol
Clarkson JE, Ramsay CR, Eccles MP, Eldridge S, Grimshaw JM, Johnston M, Michie S, Treweek S, Walker A, Young L, Black I, Bonetti D, Cassie H, Francis J, Mackenzie G, Macpherson L, McKee L, Pitts N, Rennie J, Stirling D, Tilley C, Torgerson C, Vale L. Implement Sci. 2010 Jul 20;5:57
Trials in primary care: statistical issues in the design, conduct and evaluation of complex interventions
Lancaster G, Campbell M, Eldridge S, Farrin A, Marchant M, Muller S, Perera R, Peters T, Prevost A, Rait G. . Stat Methods Med Res. 2010 Aug;19(4):349-77. Epub 2010 May 4
Cost-effectiveness of a programme to detect and provide better care for female victims of intimate partner violence
Norman R, Spencer A, Eldridge S, Feder G. J Health Serv Res Policy. 2010 Jul;15(3):143-9. Epub 2010 Mar 22.
Primary care identification and referral to improve safety of women experiencing domestic violence (IRIS): protocol for a pragmatic cluster randomised controlled trial.
Gregory A, Ramsay J, Agnew-Davies R, Baird K, Devine A, Dunne D, Eldridge S, Howell A, Johnson M, Rutterford C, Sharp D, Feder G. BMC Public Health 2010 Feb 2;10:54.
2009
The Intra-Cluster Correlation Coefficient in Cluster Randomized Trials: A Review of Definitions.
Eldridge SM, Ukoumunne OC, Carlin JB. International Statistical Review 2009, 77, 3, 378–394.
Bias in identifying and recruiting participants in cluster randomised trials: what can be done?
Eldridge S, Kerry S, Torgerson DJ. BMJ. 2009 Oct 9;339.
Financial incentives to improve adherence to anti-psychotic maintenance medication in non-adherent patients - a cluster randomised controlled trial (FIAT)
Priebe S, Burton A, Ashby D, Ashcroft R, Burns T, David A, Eldridge S, Firn M, Knapp M, McCabe R. BMC Psychiatry. 2009 Sep 28;9(1):61.
Multilevel survival analysis of health inequalities in life expectancy
Yang M, Eldridge S, Merlo J. . International Journal for Equity in Health 2009, 8:31.
Estimating the number needed to treat from continuous outcomes in randomised controlled trials: methodological challenges and worked example using data from the UK Back Pain Exercise and Manipulation (BEAM) trial
Froud R, Eldridge S, Lall R, Underwood M. BMC Med Res Methodol. 2009 Jun 11;9(1):35.
Advocacy interventions to reduce or eliminate violence and promote the physical and psychosocial well-being of women who experience intimate partner abuse
Ramsay J, Carter Y, Davidson L, Dunne D, Eldridge S, Feder G, Hegarty K, Rivas C, Taft A, Warburton A. Cochrane Database Sys. Review 2009 (3) D005043.DOI:10.1002/14651858.CD005043.pub2.
Influence of a single oral dose of vitamin D(2) on serum 25-hydroxyvitamin D concentrations in tuberculosis patients.
Martineau AR, Nanzer AM, Satkunam KR, Packe GE, Rainbow SJ, Maunsell ZJ, Timms PM, Venton TR, Eldridge SM, Davidson RN, Wilkinson RJ, Griffiths CJ. Int J Tuberc Lung Dis. 2009 Jan;13(1):119-25.
2008
Incremental prognostic value of the exercise electrocardiogram in the initial assessment of patients with suspected angina: cohort study.
Sekhri N, Feder GS, Junghans C, Eldridge S, Umaipalan A, Madhu R, Hemingway H, Timmis AD. BMJ. 2008 Nov 13;337:a2240.
Appropriateness criteria for coronary angiography in angina: reliability and validity
Hemingway H, Chen R, Junghans C, Timmis A, Eldridge S, Black N, Shekelle P, Feder G. Ann Intern Med ;149(4):221-31.
A cluster-randomised controlled trial of a brief training session to facilitate general practitioner referral to smoking cessation treatment.
McRobbie H, Hajek P, Feder G, Eldridge S. Tob Control. 2008 June17(3):173-6.
2007
Self-management education programmes by lay leaders for people with chronic conditions
Foster G;Taylor SJ;Eldridge S;Ramsay J;Griffiths C;, The Cochrane Database of Systematic Reviews, vol: 2007 Oct 17, pp:-
Educational outreach to promote screening for tuberculosis in primary care: a cluster randomised controlled trial
Griffiths C;Sturdy P;Brewin P;Bothamley G;Eldridge S;Martineau A;MacDonald M;Ramsay J;Tibrewal S;Levi S;Zumla A;Feder G; Lancet, 2007 May 5, vol: 369, pp:1528-1534
How effective are expert patient (lay led) education programmes for chronic disease?
Griffiths C;Foster G;Ramsay J;Eldridge S;Taylor S; 2007 Jun 16, BMJ, vol: 334, pp:1254-1256
A Single Dose of Vitamin D Enhances Immunity to Mycobacteria
Martineau AR;Wilkinson RJ;Wilkinson KA;Newton SM;Kampmann B;Hall BM;Packe GE;Davidson RN;Eldridge SM;Maunsell ZJ;Rainbow SJ;Berry JL;Griffiths CJ; 2007 Apr 26, Am J Respir Crit Care Med, vol: , pp:-
Good practice in statistical reporting for Family Practice
Eldridge S; 2007 Apr, Fam Pract, vol: 24, pp:93-94
Evaluating hospital at home and early discharge schemes for patients with an acute exacerbation of COPD
Taylor S;Eldridge S;Chang YM;Sohanpal R;Clarke A; 2007, Chron Respir Dis, vol: 4, pp:33-43
Effect of Patient-Specific Ratings vs Conventional Guidelines on Investigation Decisions in Angina
Junghans C;Feder GS;Timmis A;Eldridge SM;Sekhri N;Black N;Shekelle P;Hemingway H; 2007, Archives of Internal Medicine, vol: 167, pp:195-202
2006
Asking older people about fear of falling did not have a negative effect
Underwood MR;Parsons S;Eldridge SM;Spencer AE;Feder GS; 2006 Jun
The Diabetes Manual trial protocol ? a cluster randomized controlled trial of a self management intervention for type 2 diabetes
sturt j;hearnshaw H;Farmer A;dale j;Eldridge SM; 2006, BMC Family Practice, vol: 7, pp:-
Sample size for cluster randomized trials: effect of coefficient of variation of cluster size and analysis method
Eldridge SM;Ashby D;Kerry S; 2006, International Journal of Epidemiology, vol: , pp:-
Panel conditioning in population surveys: can completing questionnaires affect your health?
Underwood M;Parsons S;Eldridge SM;Spencer AE;Feder G;
2005
Randomised controlled trial of a lay-led self-management programme for Bangladeshi patients with chronic disease
Griffiths C;Motlib J;Azad A;Ramsay J;Eldridge S;Feder G;Khanam R;Munni R;Garrett M;Turner A;Barlow J; 2005 Nov 10
Why modelling a complex intervention is an important precursor to trial design: lessons from studying an intervention to reduce falls-related injuries in older people
Eldridge S;Spencer A;Cryer C;Parsons S;Underwood M;Feder G; 2005 Jul 3, J Health Serv Res Policy, vol: 10, pp:133-142
Self management education by lay leaders for people with chronic conditions (Protocol)
Griffiths C;Taylor S;Feder G;Candy B;Ramsay J;Eldridge S;Barlow J; 2005 Jan 24
PreDoVE: A pilot study to evaluate the feasibility of a primary care based intervention for improving the health care response to domestic violence.
Foster G;Ramsay J;Eldridge S;Feder G; 2005 Feb
Informed patient consent to participation in cluster randomized trials: an empirical exploration of trials in primary care
Eldridge S;Ashby D;Feder G; 2005 Apr, Clinical Trials, vol: 2, pp:91-98
2004
Beliefs and behavior of deceivers in a randomized, controlled trial of anti-smoking advice at a primary care clinic in Kelantan, Malaysia
Jackson AA;Manan WA;Gani AS;Eldridge S;Carter YH; 2004 Sep
Randomised controlled trial of support from volunteer counsellors for mothers considering breast feeding
Graffy J;Taylor J;Williams A;Eldridge S; 2004 Jan 3
Specialist nurse intervention to reduce unscheduled asthma care in a deprived multiethnic area: the east London randomised controlled trial for high risk asthma (ELECTRA)
Griffiths C;Foster G;Barnes N;Eldridge S;Tate H;Begum S;Wiggins M;Dawson C;Livingstone AE;Chambers M;Coats T;Harris R;Feder GS; 2004 Jan 17
Patterns of intra-cluster correlation from primary care research to inform study design and analysis
Adams G;Gulliford MC;Ukoumunne OC;Eldridge S;Chinn S;Campbell MJ; 2004 Aug
Lessons for cluster randomized trials in the twenty-first century: a systematic review of trials in primary care
Eldridge SM;Ashby D.;Feder GS;Rudnick AR;Ukoumunne OC;, Clinical Trials, vol: , pp:80-90
Development and preliminary examination of the predictive validity of the Falls Risk Assessment Tool (FRAT) for use in primary care
Nandy S;Parsons S;Cryer C;Underwood M;Rashbrook E;Carter Y;Eldridge S;Close J;Skelton D;Taylor S;Feder G;, Journal of Public Health, vol: 26, pp:1-6
Can a self-management programme delivered by a community pharmacist improve asthma control? A randomised trial
Barbanel D;Eldridge S;Griffiths C; 2003 Oct, Thorax, vol: 58, pp:851-854
What's wrong with recent cluster randomised trials and how do we make them better?
Eldridge S;Feder G;Ashby D;
How large should my sample size be for a cluster randomised trial with variable cluster size?
Eldridge S;Kerry S;Ashby D;
How reliable are estimates of intr-cluser correlation for binary outcomes and can we improve them?
Eldridge S;Ashby D;Feder G;
Expert Bangladeshi patients? Interim results for a randomised trial of lay-led self-management in Bangladeshis with chronic disease. Or can California come to East London
Griffiths CJ;Ramsay J;Motlib J;Azad A;Begum R;Garrett M;Barlow J;Feder G;Eldridge S;