Neurogastroenterology Group

Jump to menu
Charles Knowles

Charles Knowles

Charles Knowles undertook his preclinical training at Cambridge University and then moved to the London Hospital Medical College, qualifying in 1992, and passing the FRCS examination (London) in 1996. Prior to specialist training, he undertook a considerable body of research based at Barts and The London, and funded by the Royal College of Surgeons of England. During this time, he was awarded the degree of PhD at the University of London for his work entitled ‘Clinical and aetiological studies in slow transit constipation’. He continued to actively participate in research during Specialist Registrar training (General Surgery) in the North-East Thames Region, in the role of Clinical Lecturer in Academic Surgery.

After completing the final Intercollegiate Specialty Boards Examination in General Surgery (sub-specialty: Colorectal) he entered the Specialist Register in 2005. In September 2006, he was appointed Senior Lecturer in Colorectal Surgery on the basis of a prestigious award from HEFCE, partnered by Honorary Consultant appointments at Barts and The London and the Homerton University NHS Foundation Trusts. His main clinical interest is in the management of benign coloproctological conditions.

Research interests:

  • Neuromuscular pathological aspects of gastrointestinal motility disorders
  • The molecular basis of gut sensorimotor dysfunction, particularly in relation to visceral hypersensitivity and pain
  • The role of autoantibody-mediated disease in gut motility disorders
  • The role of clinical tests of colorectal physiology in guiding therapy

Publications:

Key publications:

Peiris M, Bulmer D, Baker M, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q, Knowles CH. Human visceral afferent recordings: preliminary report. Gut 2011; 60: 204-8.

Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Gershon MD, Hutson J, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress B, Wedel T. The London Classification of GI Neuromuscular disease. Gut 2010; 59: 882-887.

Martin JE, Hester TW, Aslam H, Sinha S, Knowles CH. Discordant practice and limited histopathological assessment in gastrointestinal neuromuscular disease. Gut 2009; 58: 1703-5.

Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Gershon MD, Hutson J, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress B, Wedel T. Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropathol 2009; 118: 271-301.

Williams NS, Murphy J, Knowles CH. The Anterior Perineal PlanE for ultra low Anterior Resection (the APPEAR technique): a pilot study. Ann Surg 2008; 247: 750-758.

Bookmark and Share