Neurogastroenterology Group

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GI neurophysiology laboratory

Neurophysiology is the study of electrical activity of the sensory and autonomic, central, and peripheral nervous system functions – dysfunctions of which are common in many neurological and general medical conditions. Quantitative assessment of these systems are essential diagnostic and prognostic tools, as well as being able to monitor progression and treatment. As well as being used in the clinic they are also useful in intensive care and intraoperative monitoring. They are also useful research tools.

Sensory evoked potentials are the electrical signals generated by the nervous system in response to sensory stimuli, which consists of a series of waves that reflect activation of neural structures along the particular sensory pathway. There is a range of techniques available to study the brain, the somatic, hearing and visual systems, these are electroencephalography (EEG), somatosensory (SSEP), auditory (AEP) and visual (VEP) potentials, respectively, as well as nerve conduction studies (NCS), which indicates the time for the signal to travel along the nerve, electromyography (EMG), which records the activity of the muscles. Diseases affecting the sensory nervous system may show abnormalities in the activity generated by one or more of the associated neural structures.

Some diseases affect the autonomic nervous system and there are a number of procedures that allow quantitative assessment of both sympathetic and parasympathetic function. These include evaluation of cardiovascular and sudomotor function, such as heart-rate variability, the Valsalva manoeuvre and sympathetic skin response. Various manoeuvres are designed to activate the sympathetic or parasympathetic nervous system providing a means by which to discriminate between the two as different diseases may differentially affect the two systems

GI neurophysiological tests available:

Sensory investigations

  • Nerve conduction studies
  • Somatosensory evoked potentials
  • Electromyography

Autonomic investigations

  • Sympathetic provocation tests
  • Cardiovascular reflexes
  • Brainstem autonomic functions
  • Assessment of sympathetic postganglionic function
  • Quantitative ionotropic fatigability test
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